Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Medulloblastoma"”.
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Mining the Medulloblastoma Genome and Transcriptome
Medulloblastoma is a devastating disease of the cerebellum, and the most common solid pediatric malignancy of the central nervous system. Recently, transcriptome-wide profiling has dissected medulloblastoma from one single disease into four disparate molecular subgroups – namely WNT, SHH, Group3 …
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Medulloblastoma : treatment and survival in HUS- area
Medulloblastom (MB) är den vanligaste maligna hjärtumören inom pediatrin och omfattar 63% av intrakraniella embryonala tumörer hos barn. Insidensnivån ligger globalt kring 0.7 fall per 100 000 invånare och medianåldern för diagnosen är 6 år. Tumören ligger i den bakre skallgropen och kan …
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Mechanisms of medulloblastoma vulnerability and new targeted therapies
Medulloblastoma (MB) is the most common malignant paediatric brain tumour accounting for about 20% of all childhood brain cancers. Over the last decade, a consensus has been reached over the existence of 4 main molecular subtypes, known as WNT-activated MB, SHH-activated MB, group 3 MB and group 4 …
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Mechanisms and Targeting of Neurodevelopmental Regulator Rest In Medulloblastoma Dissemination
<p>Molecular subgrouping of medulloblastoma (MB) has produced four subgroups: wingless (WNT), sonic hedgehog (SHH), group 3, and group 4. While patients with WNT tumors have the best prognosis, patients with SHH tumors have a more variable prognosis concurrent with metastatic disease. This subset …
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Medulloblastoma: New animal models, preclinical drug testing, and characterising immune infiltrates
Medulloblastoma is the most common malignant brain tumour in children. The current treatment for medulloblastoma consists of surgery, radiation, and chemotherapy. Although these therapies have their merits, the outcome for some patients, particularly those with MYC amplified tumours, is poor, and …
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VOLUMETRIC GROWTH MODEL OF HUMAN MEDULLOBLASTOMA IN THE NUDE MOUSE CEREBELLUM
Medulloblastoma is the most common brain tumor in children, accounting for 10-20% of primary central nervous system (CNS) neoplasms and approximately 40% of all posterior fossa tumors. It is a highly invasive embryonal neuroepithelial tumor that typically arises in the cerebellar vermis and has a …
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Intelligence and Academic Achievement in Ten-Year Survivors of Childhood Medulloblastoma
Advances in the treatment of childhood medulloblastoma have markedly increased survival rates in recent decades. Although survival rates have improved, research has demonstrated that significant cognitive consequences are common in patients who have survived medulloblastoma. Few studies exist that …
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RADIOSENSITIZING EFFECTS OF THROMBIN PEPTIDE TP508 ON MEDULLOBLASTOMA CANCER STEM CELLS
… deaths in children in the United States, with medulloblastoma leading all pediatric cases. With intensive treatments, including surgery, radiation, and/or chemotherapy, the average 5-year survival rate is approximately 60-80 percent. Unfortunately, nearly all survivors experience hindered …
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Gene expression of DNA repair proteins in colorectal cancer and medulloblastoma
… at the transcriptome and proteome level in DAOY medulloblastoma cells and cisplatin – resistant DAOY cells. Additionally, attempts were made to generate mesothelioma-derived cancer stem cells and preliminary gene expression analyses were undertaken on human embryonic stem cells. Thus, RNA was …
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Automating The Radiation Therapy Treatment Planning Process For Pediatric Patients With Medulloblastoma
… planning process for pediatric patients with medulloblastoma. Radiation therapy for medulloblastoma consists of radiation to the craniospinal axis (CSI) and a boost of radiation to the post-operative tumor resection cavity. In this study we automated the treatment planning process for the …
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Effect of Extrinsic Motivation on Academic Fluency Outcomes in Survivors of Pediatric Medulloblastoma
Medulloblastoma is the most commonly diagnosed malignant pediatric brain tumor. While deficits in processing speed, memory, attention, and IQ are well documented in childhood medulloblastoma survivors, impairments in academic functioning have not been adequately studied in this population, despite …
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Investigating the Fate of Pre-neoplastic Cells in a Mouse Model of Medulloblastoma
… (ptc) mutant mouse, a model for the brain tumor medulloblastoma was used. Pre-neoplastic cells (PNCs) are found in most ptc mutants during early adulthood, but only 15% of these animals develop tumors. Although PNCs are found in mice that develop tumors, the ability of PNCs to give rise to tumors …
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Profiling medulloblastoma and juvenile pilocytic astrocytoma brain tumours in a South African paediatric cohort
… of childhood brain tumour, the highly malignant Medulloblastoma (MB) and the generally less aggressive Juvenile Pilocytic Astrocytoma (JPA) with relation to their molecular biology and their clinical correlates to begin to address this gap and build capacity for further molecular-based studies in …
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Cancer systems biology : functional insights and therapeutic strategies for medulloblastoma from omic data integration
Medulloblastoma (MB) is a chiefly pediatric cancer of the cerebellum that has been studied extensively using genomic, epigenomic, and transcriptomic data. It comprises at least four molecularly distinct subgroups: WNT, SHH, Group 3, and Group 4. Despite the detailed characterization of MB, many …
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The Generation of Alternative Transcripts as a Means of Regulating Phosphorylation in Sonic Hedgehog Medulloblastoma
… mRNA level. The sonic hedgehog (SHH) subtype of medulloblastoma (MB), the most common malignant pediatric cerebellar tumor, arises from granule neuron precursors (GNPs) through aberrant SHH signaling. Murine postnatal day 7 (P7) GNPs are highly proliferative and share strong molecular and …
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Vulnerability to G - Quadruplexes in BRCA2 - Null Medulloblastoma: A Protective Role for the PIF1 Helicase
… develop the most common pediatric brain cancer medulloblastoma (MB) before three years of age. Medulloblastoma is often the first malignancy in these children who have a high likelihood of developing several other cancers in their lifetime. MBs have a complex mutational landscape characterized …
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Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma
… treatments for cancer patients. The brain tumour Medulloblastoma is the leading cause of cancer-related death in children and infants meaning research into better treatment of this cancer is vital. Using cell culture model systems and bioinformatics resources, this project investigated the …
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