Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Medroxyprogesterone Acetate"”.
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Depot medroxyprogesterone acetate versus norethisterone oenanthate for long-acting progestogenic contraception : a systematic review
… progestogen-only contraceptives (IPCs) depot medroxyprogesterone acetate (DMPA) and norethisterone oenanthate (NET-EN) continue to be extensively used in some countries, forming a large proportion of the health system's expenditure on contraception. Both these highly effective contraceptives …
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The molecular actions of medroxyprogesterone acetate on androgen receptor signalling and the promotion of breast cancer.
… estrogens (CEE) and the synthetic progestin medroxyprogesterone acetate (MPA) and increased breast cancer risk in post-menopausal women. Since the first WHI report in 2002, other observational studies have demonstrated that it is the addition of the synthetic progestin in the cHRT that is …
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In Vitro Studies of the Anti-Leukaemic Activity of Bezafibrate and Medroxyprogesterone Acetate Against Chronic Lymphocytic Leukaemia
… drug Bezafibrate (BEZ) and the sex steroid, medroxyprogesterone acetate (MPA) have been shown to have anti-leukaemic properties in other settings. In this study the in vitro efficacy of BEZ and MPA on resting CLL cells (representing resting cells in the periphery) and when stimulated to …
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Women’s use of sub-cutaneous depot-medroxyprogesterone acetate in a basket of contraceptives among women in Nigeria: involvement of male partners
… increasing number of individuals are using depotmedroxyprogesterone acetate (DMPA-SC) for family planning (FP) since it is discreet, easy to use, and highly effective. In Nigeria, there is a paucity of information about factors influencing the adoption and uptake of DMPA-SC among women and …
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Investigation of differential TNFα-induced interleukin-6 gene regulation by synthesis progestins medroxyprogesterone acetate (MPA) and norethindrone acetate (NET-A) in human endocervical epithelial cells and the role of the unliganded glucocorticoid receptor
… and cell proliferation. The synthetic progestins medroxyprogesterone acetate (MPA) and norethisterone (NET) and its derivatives (norethisterone enanthate (NET-EN); norethisterone acetate (NET-A)) are synthetic steroidal hormones designed to elicit progestational effects similar to those of the …
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Intrauterine position in pigs: effects on conceptus development and fetal fluids steroid content
… Fetuses from OVX gilts treated with either medroxyprogesterone acetate (MPA) I or progesterone (P4) showed differences in placental length due to intrauterine position. Allantoic and amniotic fluid content of any of the steroids studied from OVX MPA- and P4-treated gilts was not altered as a …
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The Effect of Progesterone Only Contraception on the Accuracy of Cervical Cytologic interpretation
… progesterone if the woman uses injectable depot medroxyprogesterone acetate or a progesterone intrauterine device. Previous study results have been inconsistent regarding the effect of progesterone on relationship between cytology and histology interpretation. The purpose of this exploratory …
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Inhibition of progestin-induced VEGF in mammary cancer by curcumin and 2-methoxy estradiol and their potential role as anti-angiogenic & chemopreventive compounds
… progestin component, the most common of which is medroxyprogesterone acetate (MPA). It is likely that breast cancers arise due to progestin-dependent release, from breast tumor cells, of vascular endothelial growth factor (VEGF), a potent angiogenic growth factor. In the present study I show that …
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Modulation of GR transcriptional signalling by HIV-1 Vpr insights into regulation by progestins
… reproductive system and the synthetic progestins medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A) are extensively used as injectable contraceptives. MPA has been shown to act as a partial or full GR agonist and recent evidence indicates that injectable MPA increases HIV-1 …
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Cell-Type-Specific Requirement of Progestereone Receptor for Suppression of Cell Proliferation and Carcinogenesis in the Cervix
… lab has demonstrated that synthetic progestin medroxyprogesterone acetate (MPA) prevents and regresses cervical cancer in the HPV transgenic mouse model. Our lab also has demonstrated that stromal estrogen receptor alpha (ERα) mainly mediates pro–tumorigenic action of E2. The goal of my study …
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Suppression of Cervical Cancer by the Progesterone Receptor Signaling
… Our laboratory has demonstrated that PR agonist medroxyprogesterone acetate (MPA) promotes regression of cervical cancer and cervical intraepithelial neoplasia (CIN) in the K14E6/K14E7 mice. Goals of my dissertation project were to determine whether cervical cancer recurs after MPA therapy and …
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Role of the glucocorticoid receptor and HIV-1 Vpr in inflammatory gene expression and HIV-1 LTR transcription in response to dexamethasone and progestogens
… data suggests that the injectable contraceptive medroxyprogesterone acetate (MPA), unlike norethisterone enanthate (NET-EN), increases susceptibility to infections such as HIV-1. The first part of this thesis investigated the differential effects, molecular mechanisms of action and steroid …
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Effect of Postmenopausal Hormone Replacement Therapy on Heart Rate Variability
… of PremPro™ (estrogen: 0.625 mg; medroxyprogesterone acetate: 2.5 mg).</p> <p>PMW demonstrated lower, but normal, HRV mean values than those for healthy female controls (n=118; age=35.6±11.8 years), Mean values were within normal limits established for the laboratory. Paired …
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Porcine intrauterine steroidogenesis: luteal vs. intrauterine progesterone as a mediator of prenatal survival, conceptus development and in vitro steroid production by the placenta and endometrium
… gilt. In chapter 3, ovariectomy (OVX) and medroxyprogesterone acetate (MPA) treatment at two stages of gestation (d19-29 or d59-69) resulted in maintained pregnancy, normal fetal survival rates, normal conceptus development, and typical plasma estrogens when compared to intact, control …
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Effects of long-term hormone treatment on cognitive behavior and the structure of the medial prefrontal cortex during aging in female rats
… young adult animals and have not administered medroxyprogesterone acetate (MPA), the most commonly prescribed progestin. The aging brain may respond differently to the presence of these hormones. Therefore, the effects of long-term hormone treatment during aging on cognition and neuroanatomy …
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Differential effects of combinations of anti-retrovirals and progestins on gene expression and HIV-1 replication in cells of the female genital tract
… and tissue. Co-stimulation with the progestin medroxyprogesterone acetate (MPA) revealed that MPA can potentiate and inhibit the DPV-induced pro-inflammatory effects, in a gene-specific manner in cervical cells. DPV was shown to alter the efficacy and potency of an androgen receptor (AR) …
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Pregnancy Intendedness in a High-Risk Obstetric Population in a Tertiary Hospital.
… of contraceptive methods other than the depot-medroxyprogesterone acetate (DPMA) injectable, the combined oral contraceptive (COC) pill, the sub-dermal implant, and the loop intrauterine device with 76.1%, 26.1%, 13.5% and 4.5% of the women having ever used these respectively. Only 24 women …
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Differential effects of progestogens on HIV-1 replication and host gene expression in primary PBMCs and cervical tissue explants
The synthetic progestogens, medroxyprogesterone acetate (MPA) and norethisterone enanthate (NET-EN),are widely used in developing countries as injectable contraceptives, where disease burden is high.Levonorgestrel (LNG) is a common progestogen used in oral contraceptives and intrauterine devices. …
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A randomised controlled trial studying the effects of the copper intrauterine device and the injectable progestogen contraceptive on depression and sexual functioning of women in the Eastern Cape
… of a long-acting injectable contraceptive, Depot Medroxyprogesterone Acetate (DMP A), compared with the initiation of a copper Intrauterine Contraceptive Device (Cu-IUD) after childbirth on depression and sexual functioning. After counselling, 242consenting pregnant women were randomised to …
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Risk factors for high risk Human Papillomavirus (HR-HPV) infection among unscreened African women aged thirty-five to sixty-five years
… 2.15, 95% CI; 1.22; 3.80), current use of Depot medroxyprogesterone acetate (DMPA) (OR; .. 1.37, 95% CI; 1.13; 1.65), current use ofNorethindrone enanthate (Net-EN) (OR; 1.39, 95% CI; 1.02; 1.88), currently married (OR; 0.71, 95% CI; 0.62; 0.81), mean number of live births (OR; 1.10, 95% CI; …
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