"Medicinal and Pharmaceutical Chemistry" · 113 results

Target Based Design and Synthesis of Fused Pyrimidines in the Potential Treatment of Cancer and Opportunistic Infection

Shah, Khushbu2018

… describes an introduction, background and research progress in the areas of agents designed as (a) selective Pneumocystis jirovecii dihydrofolate reductase (pjDHFR) inhibitors for pneumocystis pneumonia (PCP) infection; (b) inhibitors of microtubule polymerization and multiple …

duquesne Repository record for Target Based Design and Synthesis of Fused Pyrimidines in the Potential Treatment of Cancer and Opportunistic Infection (opens in a new tab)

Design and Synthesis of Novel Chloroquine-based Antimalarials

Murphy, Kevin Vincent

portland-state Repository record for Design and Synthesis of Novel Chloroquine-based Antimalarials (opens in a new tab)

QUANTIFICATION OF ASPARTAME IN LOZENGES AND TABLETOP SWEETENERS VIA MULTIPLE PARAMETER MANIPULATION BY USING DISSOLUTION STUDIES WITH UV-VIS, ULTRA-HPLC, AND MATHEMATICAL DRUG MODELING

Zec, Zeljka2027

… sweetener that has been around since the 1900s and is considered 200 times sweeter than sugar. Its main purpose is to serve as a sugar substitute in “diet” food and beverages. It is also consumer friendly by having a high availability, and an affordable price. Additionally, aspartame is found in …

kennesaw Repository record for QUANTIFICATION OF ASPARTAME IN LOZENGES AND TABLETOP SWEETENERS VIA MULTIPLE PARAMETER MANIPULATION BY USING DISSOLUTION STUDIES WITH UV-VIS, ULTRA-HPLC, AND MATHEMATICAL DRUG MODELING (opens in a new tab)

Development of Novel Peptide-Doxorubicin Conjugates for Targeting Triple-Negative Breast Cancer

Saghaeidehkordi, Azam2023

… breast cancer (TNBC) is the most aggressive and difficult to treat subtype of breast cancer. Chemotherapy is an active treatment option in combination with other treatments; however, the side effects limit the effective therapeutic dose. To selectively target the cancer cells, I have …

chapman Repository record for Development of Novel Peptide-Doxorubicin Conjugates for Targeting Triple-Negative Breast Cancer (opens in a new tab)

Altering the Regiospecificity of C6 Indole Prenyltransferase Enzymes Towards Drug Development

Aoun, Ahmed R2021

… small molecules leads to changes in structural and biological activities. Understanding the structural insights as well as the mechanisms by which PTs function allows us to utilize PTs as a unique approach towards drug development. PriB PT is an example of aromatic PTs that has been …

chapman Repository record for Altering the Regiospecificity of C6 Indole Prenyltransferase Enzymes Towards Drug Development (opens in a new tab)

Synthesis of Novel 6-Substituted and 5-Substituted Pyrrolo[2,3-D] Pyrimidine Antifolates as Targeted Anticancer Therapies

Li, Xinxin2019

… will give an introduction, background and current research progress in the areas of antifolates and chemotherapy of anticancer. The design and synthesis of classical 6- substituted pyrrolo[2,3-d]pyrimidines and 5-substituted pyrrolo[2,3-d]pyrimidines as potential …

duquesne Repository record for Synthesis of Novel 6-Substituted and 5-Substituted Pyrrolo[2,3-D] Pyrimidine Antifolates as Targeted Anticancer Therapies (opens in a new tab)

The Antimalarial Activity of PL74: A Pyridine-Based Drug Candidate

Hodson Shirley, Cheryl Anne

portland-state Repository record for The Antimalarial Activity of PL74: A Pyridine-Based Drug Candidate (opens in a new tab)

Design, Synthesis, & Biological Evaluation of Novel Het-Aromatic/Aromatic Analogs for the Treatment of HIV, Cancer, & Cognitive Dysfunctions

GUPTA, MOHIT2020

… an instrumental role in the pathogenesis of HIV and HCV virus. Using structure-based drug we designed and synthesized small molecule inhibitors of cyclophilin A. These inhibitors were biologically evaluated for their ability to inhibit WT HIV-1 inhibition. Mitogen-Activated Protein Kinase …

duquesne Repository record for Design, Synthesis, & Biological Evaluation of Novel Het-Aromatic/Aromatic Analogs for the Treatment of HIV, Cancer, & Cognitive Dysfunctions (opens in a new tab)

Molecular Mechanisms of DNA Protection by Tardigrade Damage Suppressor Protein (Dsup): Structural Adaptation and Functional Interactions

Tran, Huy2028

Ionizing radiation and reactive oxygen species (ROS) pose significant threats to genomic integrity, leading to DNA damage, mutations, and disease. Tardigrades, extremotolerant organisms, exhibit remarkable resilience to such stressors, largely attributed to the DNA damage suppressor protein …

chapman Repository record for Molecular Mechanisms of DNA Protection by Tardigrade Damage Suppressor Protein (Dsup): Structural Adaptation and Functional Interactions (opens in a new tab)

Amphiphilic Cyclic Cell-Penetrating Peptides Containing Tryptophan and Arginine as Anticancer Agents and Drug Delivery System

Zoghebi, Khalid2024

… increasing number of alternative tryptophan (W) and arginine (R) were synthesized and evaluated as a molecular transporter and for their ability to deliver doxorubicin (Dox) and large molecular weight molecules, such as siRNA and proteins. We prepared a cyclic peptide containing alternative …

chapman Repository record for Amphiphilic Cyclic Cell-Penetrating Peptides Containing Tryptophan and Arginine as Anticancer Agents and Drug Delivery System (opens in a new tab)

Effect of Estrogen on LPS-induced human endothelial cell adhesion moledule expression and calcium signaling

Franco, Rohini-Ann2005

u-pacific Repository record for Effect of Estrogen on LPS-induced human endothelial cell adhesion moledule expression and calcium signaling (opens in a new tab)

Synthesis of 2,4-Diaminopyrido [2,3-d] pyrimidines and 2,4-Diaminoquinazolines as Inhibitors of Dihydrofolate Reductase and as Anti-tumor Agents

Adair, Ona2019

Abstract withheld

duquesne Repository record for Synthesis of 2,4-Diaminopyrido [2,3-d] pyrimidines and 2,4-Diaminoquinazolines as Inhibitors of Dihydrofolate Reductase and as Anti-tumor Agents (opens in a new tab)

Synthesis of novel 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as selective and potent anti-tumor agents

Karim, Mohammad2019

… decades many folate analogs have been discovered and several compounds are successfully being used as anticancer agents. Methotrexate (MTX), pemetrexed (PMX), raltitrexed (RTX): are a few examples of classical antifolates that are currently in clinical use. Although these compounds are widely …

duquesne Repository record for Synthesis of novel 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as selective and potent anti-tumor agents (opens in a new tab)

Synthesis and Evaluation of Tetrahydroprotoberberines as Dopamine Receptor Ligands

Gadhiya, Satishkumar VThe Graduate School and University Center of The City University of New York2019

… domains; D1-like DA receptors (D1, D5) and D2-like DA receptors (D2-D4). DA receptor specific ligands have been exploited as a means for studying the prognosis and curing several CNS disorders. Though several efforts have been devoted to discover selective and potent DA receptor ligands, …

cuny-grad Repository record for Synthesis and Evaluation of Tetrahydroprotoberberines as Dopamine Receptor Ligands (opens in a new tab)

The Development of a Novel Peptide-Drug Conjugate for Treating Triple-Negative Breast Cancer

Than, Phi-Phung2024

… breast cancer subtype with poor prognosis and is difficult to treat. A diagnosis of TNBC means that the three most common types of receptors known to fuel most breast cancer growth–estrogen, progesterone, and HER2– are not present in the cancer tumors. Since the tumor cells lack necessary …

chapman Repository record for The Development of a Novel Peptide-Drug Conjugate for Treating Triple-Negative Breast Cancer (opens in a new tab)

Design, Synthesis, and Evaluation of a Novel Cytotoxic Peptide-Doxorubicin Conjugate Targeting Triple-Negative Breast Cancer

Ziaei, Elmira2023

… aim of this thesis was to design, synthesize, and characterize a novel peptide-doxorubicin conjugate, evaluate in vitro stability and cytotoxicity properties of the conjugate and study its mechanism for uptake into the triple-negative breast cancer (TNBC) cells. For the synthesis of the …

chapman Repository record for Design, Synthesis, and Evaluation of a Novel Cytotoxic Peptide-Doxorubicin Conjugate Targeting Triple-Negative Breast Cancer (opens in a new tab)

The Development of a Cancer-Targeting Peptide-Drug Conjugate for the Treatment of Melanoma

Dill, Cassandra2021

Cancer is an ongoing global pandemic which has caused a dramatic shift in research priorities. One of the most aggressive and difficult to treat has invariably remained metastatic melanoma. Although encompassing only 4% of overall skin cancer diagnoses, chances for recovery were slim until …

chapman Repository record for The Development of a Cancer-Targeting Peptide-Drug Conjugate for the Treatment of Melanoma (opens in a new tab)

Design, Synthesis and Biological Evaluation of Novel Cannabinoid Antagonist

Verma, Abha

… applications for the treatment of cannabinoid and psychostimulant addiction. The rationale for the design for our target was to incorporate a bioisosteric 1,2,3-triazole ring into the vicinal diaryl group revealed in the prototypical antagonist/inverse agonist SR141716 (Rimonabant) that was …

uno Repository record for Design, Synthesis and Biological Evaluation of Novel Cannabinoid Antagonist (opens in a new tab)

The Synthesis of pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as receptor tyrosine kinase inhibitors or tubulin inhibitors or inhibitors of dihydrofolate reductases and the development of inhibitors or inhibitors of dihydrofolate reductases and the development of metal-catalyzed cross-coupling reactions

Namjoshi, Ojas2019