Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"Medicin (människa och djur)"”.
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Protein FOG at the interface between G streptococci and human host defence lines
Group G streptococci (GGS) may be of four different species and may infect humans and also animals. S. dysgalactiae equisimilis most commonly cause human GGS infections. These bacteria are part of the normal flora, but can cause pharyngitis, erysipelas and impetigo. In the immunocompromised host …
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Pain induced by propofol - clinical studies on drug composition and adminstration
Over the last 25 years a number of new anaesthetic drugs have been introduced on the market to allow for better patient satisfaction and faster recovery after anaesthesia and sedation. Propofol (2,6-di-isopropylphenol), one of our most common iv anaesthetics, is associated with pleasant sleep and …
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Assessment and treatment of dizzy patients in primary health care.
Dizziness is a common reason for visits to primary health care, especially among elderly patients. From a physiotherapeutic perspective, this thesis aims to study the assessment and treatment of dizzy patients in primary health care. Interventions in papers I, III and IV comprised a vestibular …
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Laminins in blood vessel development and disease -functional aspects in angiogenesis, atherosclerosis, and muscular dystrophy
… identify the cause of this exclusion. Immunohistochemical and quantitative PCR studies suggested that extraocular muscles were spared due to high expression of the laminin ?4 chain, which could enable a sustained activation of the integrin ?7X1?1D. In conclusion laminin isoform transition and …
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Health Promotion Intervention in Mental Health Services
The aim of this thesis was to define and develop the concept of health promotion in mental health services as well as to develop a questionnaire to measure patients? subjective experiences of health promotion intervention in mental health services. The samples consisted of 12 patients in study I …
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Mechanisms behind the lipid-lowering effects of ACTH - Studies in different experimental models
Abstract Adrenocorticotrophic hormone (ACTH) has strong and direct lipid-lowering effects in man. All apoB-containing lipoproteins, i.e. VLDL, LDL, Lp(a), are reduced by 25-30%. In contrast, levels of HDL increase about 10%. In hepatic cell cultures, ACTH inhibits expression and secretion of apoB. …
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Hypoxia-induced phenotypic modulation of human neuroblastoma cells
Neuroblastoma is a childhood tumour derived from cells of the sympathetic nervous system, which are arrested at low differentiation stages. Low differentiation stage and high tumour stage correlate to poor outcome. In earlier studies we have found that hypoxia induces dedifferentiation of …
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Signal transduction in macrophages. Intracellular pathways activated by microbial constituents
Macrophages play an essential role in the defense against infection by phagocytosis and by production of inflammatory mediators. Such mediators are TNF? and eicosanoids. Many microbial agents elicit arachidonate release in macrophages that lead to the formation of eicosanoids. This thesis is based …
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Infections in small children and their families - symptoms,consultations and antibioitcs
Infectious symptoms in infants and their families are common. With rising age the number of symptom day decreases, but increases again for the parents of infants. About one quarter of the symptom days lead to absence from daycare among the infants but the social remuneration system was used by the …
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Childhood sexual abuse. Women's Mental and Social Health Before and After Group Therapy
The aim of the study was to evaluate changes in psychological and social variables before and after group therapy for adult women who were sexually abused in childhood. Other aims were to describe and evaluate the traumafocused group therapy by consumer satisfaction, to describe the women's health …
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WOMEN WITH IRRITABLE BOWEL SYNDROME. Aspects of quality of life and health.
Irritable Bowel Syndrome (IBS) is a common, worldwide, functional disorder affecting a significant number of people, predominantly women. Etiology and pathophysiology is insufficiently understood, but the research over the past decade has led to progress in the understanding of IBS, and it is …
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IRON NUTRITION DURING EARLY CHILDHOOD. Factors influencing iron status and iron intake.
The overall aim of this thesis was to describe the prevalence of iron deficiency (ID) and factors influencing iron status and iron intake among otherwise healthy children. The specific aim in paper I+II was to describe the prevalence of ID among 2 ½-year-old children in relation to intake of cow's …
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Mechanisms for Targeting of Proteins to Secretory Lysosomes of Haematopoietic Cells
The cells of the innate immune system are essential for the host's first line defence against infection. Among these cells the neutrophil granulocyte has a central role by the production of antibiotic proteins and peptides. These are targeted for storage in secretory lysosomes and other neutrophil …
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The impact of genetic, environmental and life-style factors on male reproductive function
Recent studies have indicated a decline in sperm number in the western world during the past 50 years, sperm concentration changing from 113 to 66 millions per mL. Furthermore, significant geographical differences in male reproductive function have been observed. In Finland, the sperm concentration …
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Recombinant CXCR4/CCR5 hybrid receptors as tools for studies of HIV-1 receptor usage
The chemokine receptors CCR5 and CXCR4 are required, together with CD4, for the entry of HIV-1 into target cells. CCR5 using HIV-1 dominates during transmission and the asymptomatic phase of infection. During progression, virus phenotypes with the ability to use CXCR4 emerge in about 50% of …
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The role of the leukemia-associated ETO homologue repressors in hematopoiesis
The fusion protein AML1-ETO is observed in acute myeloid patients with the chromosomal translocation t(8;21). Cells with this chimeric protein have impaired granulocytic and erythroid differentiation with accumulation of myeloblasts. The transcriptional co-repressor ETO (Eight Twenty One) was …
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THE ROLE OF PHOSPHODIESTERASE 3B IN CAMP-MEDIATED REGULATION OF INSULIN SECRETION
Type 2 diabetes mellitus (T2DM) is characterized by various combinations of ?-cell failure and insulin resistance leading to hyperglycemia and glucose intolerance. In order to maintain glucose tolerance in the insulin resistance state, increased insulin secretion is a requirement and it is because …
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Progenitor cells in the postnatal central nervous system, characterization and genetic manipulation
New neurons are only generated in two places of the postnatal brain; the subventricular zone (SVZ) and hippocampus. The SVZ-derived cells specifically migrate to the olfactory bulb where they give rise to new interneurons. We have genetically manipulated the postnatal SVZ progenitor cells with the …
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Molecular and morphological studies on non-healing venous leg ulcers.
Chronic skin ulcers are a major health problem and an increasing burden on health care providers. These ulcers have various underlying causes, such as venous or arterial insufficiency, diabetes, or vasculitis. Non-healing venous leg ulcers represent a condition characterized by excessive …
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The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function
In all higher organisms, there is a need for intercellular communication. G-protein coupled receptors (GPCRs), located on the cell surface, play an important role in this communication. Cells synthesize and release signalling molecules (ligands), which produce a specific response only in those …
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