Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Medical Pathology"”.
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The problem of pain: a heuristic and structural existential analysis of unexplained physical pain
… of recovery from chronic pain in the absence of medical intervention. Chronic pain is a debilitating condition that inflicts significant human suffering and costs the economy of the Western world £billions each year. Despite advances in modern medicine pain remains poorly understood and difficult …
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Autism, Neurodiversity, and the Good Life: On the Very Possibility of Autistic Thriving
… self-advocates who argue in favour of de-medicalising and instead politicising autistic disablement and distress. However, the originality of this thesis lies in three key factors. First: it focuses more specifically on the purported impossibility of thriving autistic personhood, since I …
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Vision Impairment and Depression in the Older Adult
… a social construction outcome rather than as a medical outcome. Vision impairment is the stressor which is mediated by health (falls, functioning and self-health report), financial resources (education, income and having only public health insurance) and social support (marital, living along, …
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A 12-month retrospective descriptive analysis of a single helicopter emergency medical service operator in four South-African provinces
Introduction: Helicopter Emergency Medical Services (HEMS) forms an important role in integrated modern emergency medical services and have a suggested mortality benefit in certain patient populations, such as those affected by severe trauma or with time-sensitive pathologies in rural areas. …
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Age-related genetic and epigenetic chromosomal changes: A twin study
The primary aims of this study were to examine acquired genetic and epigenetic changes that occur in individuals with increasing age and to determine how these changes are influenced by genetic/environmental factors. Acquired genetic changes were assessed by determining the frequency and …
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Type I Insulin-Like Growth Factor Receptor Tyrosine Kinase As A Molecular Target In Mantle Cell Lymphoma
Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoid malignancy representing 5-10% of all non-Hodgkin’s lymphomas. It is distinguished by the t(11;14)(q13;q32) chromosomal translocation that juxtaposes the proto-oncogene CCND1, which encodes cyclin D1 at 11q13 to the IgH gene at 14q32. MCL …
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Determination of Pancreatic and Salivary Amylase By Enzyme Immunoassay and Their Prevalence in Hyperamylasemic Patients
<p>Currently, amylase determinations are nonspecific for the organ source and are based entirely on the enzymatic properties of amylase to produce a measurable product or byproduct. The determination of pancreatic amylase is important in the diagnosis of acute pancreatitis. Most commercially …
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EVALUATING SOLUBLE AXL AS A BIOMARKER FOR GLIOBLASTOMA
<p>AXL, a receptor tyrosine kinase, is known to promote malignant phenotypes in various types of cancer. AXL overexpression is commonly observed in glioblastoma and correlates with a worse prognosis. Detectable in most biological fluids, the extracellular domain of AXL, sAXL, is the product of …
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Investigating Medical Examiners' Practices: Genetic Evaluation For Fatal Acute Aortic Dissection
… also in risk stratification for relatives and medical management to prevent premature death from dissection. Due to its high fatality rate, medical examiners and coroners (ME/Cs) may be the first to identify TAD cases and initiate genetic testing for the decedent and at-risk relatives. ME/Cs …
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Insulin-like growth factor binding protein-3 (IGFBP-3) plays an essential role in cellular senescence: molecular and clinical implications.
Normal somatic cells have a limited proliferative capacity in vivo and in vitro, termed senescence and later, thought to contribute to molecular and cellular organismal aging. There are several studies that demonstrate the importance of the GH/IGF axis in longevity, aging and cellular senescence. …
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Acquired Cytogenetic Changes in Adult Twins Discordant for a History of Childhood Sexual Abuse
<p>The primary study aim was to evaluate the latent biological effect of childhood sexual abuse (CSA) on adults by quantifying acquired cytogenetic changes and cortisol levels in identical twins who were discordant (N=22) or concordant (N=2) for a history of CSA. Although the difference scores for …
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Circulating tumour DNA: A non-invasive biomarker for melanoma
Cutaneous melanoma accounts for 90% of all skin cancer deaths (Balch et al., 2010) and is responsible for 3.6% of deaths from cancer in Australia (Australian Institute of Health and Welfare, 2016). Whilst early detection and successful surgical removal of primary melanomas have improved survival …
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Imaging Based Prediction of Pathology In Adult Diffuse Glioma With Applications to Therapy and Prognosis
… relationships between imaging and underlying pathology. These relations increase the value of MRI by allowing it to be a better surrogate for underlying pathology and they allow evaluation of the underlying biological heterogeneity via imaging. This provides an approach to answer questions …
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The Comparative Ultrastructure of the Choroid Plexus in Certain Animal Species
<p>Employing the electron microscope, the writer studied the ultra-structure of the choroid plexus of the lateral and the 4th ventricles of the brain in seven species of animals comparatively. No such extensive comparative investigation has been made before with this instrument. The animals …
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Taz As A Regulator of Mesenchymal Transformation and Clinical Aggressiveness In Gliomas
<p>Glioblastoma multiforme (GBM) is an aggressive, high grade brain tumor. Microarray studies have shown a subset of GBMs with a mesenchymal gene signature. This subset is associated with poor clinical outcome and resistance to treatment. To establish the molecular drivers of this mesenchymal …
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The New Role of Proprotein Convertase Subtilisin/Kexin Type 9: A Connection of Proprotein Convertase Subtilisin/Kexin Type 9, Apolipoprotein B, and Autophagy
<p>Plasma low-density lipoprotein (LDL) levels are positively correlated with the incidence of coronary artery disease. In the circulation, the plasma LDL clearance is mainly achieved by the uptake via LDL receptor (LDLR). Proprotein convertase subtilisin/kexin type 9 (<em>PCSK9</em>) is a newly …
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Characterizing the Cellular Response to Astrovirus Infection in the Central Nervous System
… VA1 and classical HAstV1 genotypes, induce CNS pathology in human neurons and astrocytes. Utilizing primary human neurons and astrocytes from various brain regions, this research investigates the cytotoxic effects, apoptotic pathways, and inflammatory responses triggered by these viruses. This …
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Role of Phosphorylated Dicer1 In Tumor Progression
<p>DICER1 is a multidomain enzyme discovered and widely recognized for its function in small non-coding microRNA (miRNA) synthesis. In cancer development, DICER1 functions as a haploinsufficient tumor suppressor which regulates miRNAs and Epithelial-to-Mesenchymal Transition (EMT). The Arur …
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The Hormonal Regulation of the Claudin Genes in the Ovary
The ovary is a dynamic organ that responds to many hormonal signals. When these hormonal signals are disrupted, ovarian dysfunction can occur. One such example is Polycystic Ovarian Syndrome (PCOS). PCOS patients suffer from high levels of testosterone. Excess testosterone may misregulate genes in …
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The Impact of Candida albicans Glycogen on Fitness, Virulence and Host Response
<p>Candida albicans is an opportunistic human fungal pathogen that presents in healthy persons colonizing the oropharyngeal, esophageal, and gastrointestinal mucosa. This polymorphic fungal pathogen remains a leading cause of both invasive and superficial mycoses. C. albicans can cause …
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