Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Medical Neurobiology"”.
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Effects of GABA on inflammation and intestinal barrier disruption
<p> Gut dysbiosis and intestinal barrier disruption have been linked to multiple sclerosis (MS). Our previous works show that experimental autoimmune encephalomyelitis (EAE) induction modifies the gut's microbiota composition, reducing frequencies of gamma-aminobutyric acid (GABA)-producing …
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Investigating the protective effects of farnesol formations against neuroinflammation
<p>Farnesol (FOL) is a naturally-produced 15-carbon organic acyclic sesquiterpene alcohol (isoprenol) that acts as a potent blocker of neuronal voltage-gated Ca2+ channels (L- and N-type) and is found in the human brain. FOL has potent anti-oxidant and antiinflammatory effects in vitro and is …
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Genetic Control of Eye Development, a Case Study Focused on the Murine Mutation Belly Spot and Tail (BST)
<p>Development of the eye is controlled by a network of genes, often conserved, that regulate the timing and location of cellular differentiation. One approach to understanding this network of genes and their interaction is to focus on mutations, spontaneous or induced, that predictably disrupt the …
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Modeling Post Stroke Respiratory Dysfunction, Apneas and Cognitive Decline
<p><strong>Modeling Post Stroke Respiratory Dysfunction,</strong></p> <p><strong>Apneas and Cognitive Decline</strong></p> <p>Anthony Patrizz, B.A.</p> <p>Advisory Professor: Louise McCullough M.D., Ph.D.</p> <p>Stroke is a major cause of mortality and the leading cause of long-term disability in …
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Adenosine Production Is Essential for Closing the Critical Period of Cortical Plasticity
<p>Sensory inputs from the external world are represented as highly organized systems in the adult brain for effective adaptation to the environment. At the cortical level, this organization is referred to as cortical maps. The establishment of cortical maps begins with early life experiences …
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Presenilins Modulate Cellular Activity of Ryanodine Receptors
… of Ryanodine Receptors. Doctor of Philosophy (Biomedical Sciences), December, 2012, 160 pp., 7 tables, 39 figures, bibliography 241 titles. Ryanodine Receptors (RyRs) are large, endoplasmic reticulum (ER) intracellular calcium channels in excitable cells. RyRs are major cellular mediators of …
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Taste Learning in Insular Cortex: Plasticity Is Influenced by Experience Type
<p>The gustatory cortex (GC) has long been studied as the main cortical area encoding taste stimuli and likely integrates sensory, visceral, and emotional information to guide taste-related behaviors. However, our understanding of cortical taste coding on a single-cell level has only become clear …
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Estrogen's Effects on Oxidative Stress Levels in Glial Cells
<p>A decrease in astrocyte function and viability has been linked to many neurodegenerative diseases, including schizophrenia, major depressive disorders, Alzheimer’s disease, and Amyotrophic Lateral Sclerosis (ALS). Previous research indicates that some estrogens may have a positive effect on …
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Assessing Neuronal Synchrony and Brain Function Through Local Field Potential and Spike Analysis
<p>Studies of neuronal network oscillations and rhythmic neuronal synchronization have led to a number of important insights in recent years, giving us a better understanding of the temporal organization of neuronal activity related to essential brain functions like sensory processing and …
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Causal Inference Methods for Estimation of Survival and General Health Status Measures of Alzheimer’s Disease Patients
… and analyzing one of the largest high-quality medical databases containing millions of de-identified electronic health records obtained from over 110 health systems in the United States. We also analyzed demographic variables, preexisting conditions, and drug treatments. Our results show that …
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Characterizing Purkinje Cell Responses and Cerebellar Influence on Fluid Licking in the Mouse
<p>Rodents consume water by performing stereotypical, rhythmic licking movements which are believed to be driven by central pattern generating circuits located in the brainstem. Temporal aspects of rhythmic licking behavior have been shown to be represented in the olivo-cerebellar system in the …
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Multiple Myeloma and Its Treatment Alter Peripheral Nervous System Structure and Function
<p><strong>MULTIPLE MYELOMA AND ITS TREATMENT ALTER PERIPHERAL NERVOUS SYSTEM STRUCTURE AND FUNCTION </strong></p> <p>Alyssa Katarina Kosturakis, BA</p> <p>Supervisory Professor: Patrick M. Dougherty, PhD</p> <p>Peripheral neuropathy is among the most deleterious side effects of frontline …
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Cerebellar Coordination of Neuronal and Behavioral Rhythms
<p>Long known for its role in motor control, it is increasingly clear that the cerebellum is also involved in numerous cognitive and affective behaviors. Though the neuronal mechanism for the role of the cerebellum in cognition is still unclear, there is a consensus that it involves cerebellar …
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Mild Traumatic Brain Injury with Associated Visual System Dysfunction: Investigating Histopathology, Functional Correlates, and a Novel Therapeutic Immune Modulator
<p><strong>Background</strong>. Traumatic brain injury (TBI) is a significant source of morbidity and mortality worldwide. Injuries associated with moderate to severe TBI can be profound, and have historically overshadowed the significant impact mild TBI (mTBI) can have on the lives of affected …
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Effect of Acute Administration of Angiopoietin-1 In Experimental Traumatic Spinal Cord Injury: Magnetic Resonance Imaging and Neurobehavioral Studies
Spinal cord injury (SCI) is a devastating condition that affects people in the prime of their lives. A myriad of vascular events occur after SCI, each of which contributes to the evolving pathology. The primary trauma causes mechanical damage to blood vessels, resulting in hemorrhage. The …
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DNA methylation of the clusterin promoter: Associations with Alzheimer’s Disease risk and related phenotypes
Background In 2017 approximately 50 million people worldwide were living with dementia. With Alzheimer’s disease (AD), accounting for 50-70% of dementia cases making this debilitating disease, with no current effective prevention, treatment or cure, a critical healthcare concern. Genome wide …
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Calcium Channel Dysfunction in Huntington’s Disease
<p> Huntington’s disease (HD) is an autosomal dominant degenerative disease that is caused by an expansion mutation in the huntingtin protein that lengthens a naturally occurring trinucleotide CAG repeat in exon 1 resulting in striatal degeneration. The mechanism by which striatal neurons undergo …
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Genetic Analysis of Variation in Neuron Number
<p>There are large differences in neuron number both within and between species. This variation in neuron number results from both non-genetic and genetic factors. Non-genetic factors, such as litter size and parity, and genetic cofactors, such as sex, age, and body weight, can influence neuron …
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Conditional Loss of Engrailed 1/2 in Rhombic Lip-Derived Neurons Increases Intrinsic Rhythmicity and Decreases Overall Variability of Eupneic Respiration
<p>Evidence for a cerebellar role during cardiopulmonary challenges has long been established, but investigation into cerebellar involvement in eupneic breathing has been inconclusive. Given the view of the cerebellum (CRB) as a temporally coordinating structure, any investigation into the CRB …
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Pathogenicity and Protection Mediated by a Single TCRβ in Experimental Autoimmune Encephalomyelitis
<p>How the TCR repertoire, together with risk-associated major histocompatibility complex (MHC), imposes susceptibility for autoimmune disease is not fully understood. A small fraction of TCR α or β chains are “public”, and are shared by most individuals.High-throughput sequencing of the mouse TCRβ …
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