Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 90 for “"Medical Molecular Biology"”.
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Effect of Emb-9 and Let-2 Mutations on the Proper Assembly of Basement Membranes and on the Morphology of Body Wall Muscle Cells in Caenorhabditis Elegans
Collagen type IV is one of the most abundant components of the basement membrane composed of two α1 chains and one α2 chain secreted into the BM between muscle cells and the hypodermis early in embryogenesis. Worms homozygous for specific let-2 or emb-9 mutations show intracellular accumulation of …
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Analysis of a Proposed Cell Binding Site on Caenorhabditis Elegans Collagen Type Iv
Collagen IV (col IV), a basement membrane protein, provides structural support and regulation of cell migration and binding. C. elegans body wall muscle col IV consists of two alpha 1 chains and one alpha 2 chain. The human col IV molecule has a cell binding site (CBS) composed of aspartate (D) on …
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Effect Of CBD On D2 Dopamine Receptor And CB1 Cannabinoid Receptor Function And Localization
<p>Cannabidiol (CBD) is the second most abundant cannabinoid found in Cannabis sativa and its array of therapeutic effects make it a popular target of pharmacological research. Though its properties are psychoactive in nature, abuse and dependence of CBD has never been reported. Its beneficial side …
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Activation Of Tumor Cell Death Program By Targeting The Ubiquitin-Proteasome Pathway: Significance In Cancer Treatment And Prevention
… <p>Advisor: Dr. Q. Ping Dou</p> <p>Major: Cancer Biology</p> <p>Degree: Doctor of Philosophy</p> <p>The ubiquitin-proteasome pathway serves as a quality control mechanism to regulate the degradation of intracellular proteins involved in a wide array of cellular processes including tumorigeneis. …
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An investigation of the mechanism of PAX7 mediated oncogenesis via in silico and in vitro biology
… The aim of the research was to analyze the molecular mechanism or mechanisms of PAX7 mediated oncogenesis. This was achieved by: Systematic searches for cis conserved sequences within PAX7 intronic regions, which may be implicated in aberrant PAX7 expression in tumours; Comparison of …
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A Novel NGS Assay to Detect Any KMT2A Fusion Transcript at Low Levels
<p>Measurable residual disease (MRD) detection is associated with cancer relapse. Leukemias with rearrangement of the lysine methyltransferase 2 A gene (<em>KMT2Ar</em>) have an adverse prognosis with more than 80 possible fusion partner genes (FPG) identified. With the advent of effective targeted …
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Integrin Distribution in Collagen Iv Mutants and Use of Rna Interference to Identify a Collagen Iv Receptor in C. Elegans
Perlecan, a basement membrane protein, was found to be significantly decreased in collagen IV mutants. To better understand the role of collagen IV in perlecan-integrin dependent sarcomere organization, an extrachromosomal array containing a functional ßpat-3::GFP fusion gene was mated using …
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Systemic Insulin Sensitivity and Skeletal Muscle Akt Signaling in Rats Artificially Selected for Low and High Aerobic Capacity
The mechanism(s) linking physical inactivity, obesity, and type-II diabetes are unclear. I hypothesized low intrinsic aerobic capacity is associated with reduced systemic insulin sensitivity via skeletal muscle insulin signaling. After 34 generations of selective breeding, high aerobic capacity …
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Direct Effects of Metformin On Pi3K and Ras Signaling In Endometrial Cancer
<p>Metformin has antiproliferative effects through the activation of AMPK and has gained interest as an antineoplastic agent in several cancer types, although studies in endometrial cancer (EC) are limited. The aims of this project were to evaluate pathways targeted by metformin in EC, investigate …
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The Role of Exosomal Transport of Viral Agents in Persistent HIV Pathogenesis
<p>Human immunodeficiency virus (HIV) infection, despite great advances in antiretroviral therapy (ART), remains a lifelong affliction. Though current treatment regimens can effectively suppress viral load to undetectable levels and preserve healthy immune function, they cannot fully alleviate all …
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The role of PAX3/PAX7-FKHR in mesenchymal stem cell myogenic differentiation and rhabdomyosarcomagenesis
… differences, these tumors also differ at the molecular level. As in many other sarcoma types, ARMS are characterized by specific chromosomal translocations and almost 75% of cases show t(2;13) or t(1;13) translocations, involving PAX3-FKHR and PAX7-FKHR fusion genes respectively. These genetic …
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Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia
… should be considered with attempting to identify molecular-based prognostic factors for pediatric T-ALL and (2) that, depending on the NOTCH1 signaling status, modifications in the types or dosing of standard chemotherapy drugs for T-ALL, or combinations of agents capable of targeting NOTCH1, AKT …
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The Tetraspanin CD9 Localizes to Platelet-Platelet Contacts and Regulates Thrombus Stability
<p>CD9, a member of the tetraspanin family, is highly expressed on platelets (50,000-80,000 copies per platelet). Tetraspanins have been implicated in modulation of integrin function, and it is hypothesized that CD9 will modulate GPIIb-IIIa, the major platelet integrin.</p> <p> The association …
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Generation and Characterization of a Knock-In Allele of EKLF: Probing the in vivo Role of the Chromatin Remodeling Domain in Definitive Hematopoietic Cells
… allele die of anemia by E15.5 of gestation. Molecular analysis ofD221EKLF erythroblasts reveals i) a failure to activate β-globin gene transcription; ii) lack of GATA-1 and NF-E2 recruitment to the β-globin promoter; iii) a block in terminal erythroid differentiation. In contrast to erythroid …
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Different Methodologies to Characterize and Diagnose Sickle Cell Disease in Both Developed and Developing Nations
<p>Sickle cell disease (SCD) is a genetic blood disorder that causes the RBC to become sickle shaped due to a mutation in the β-globin gene encoding the protein hemoglobin. This disease causes reduced oxygen carrying capacity of RBC resulting in painful crisis, hemolytic anemia, and infection …
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Methylation of Egfr By Arginine Methyltransferase Prmt1 Enhances Egfr Signaling and Cetuximab Resistance
<p>Protein modifications of epidermal growth factor receptor (EGFR) intracellular domain are well known regulators of EGFR functions whereas those of its extracellular domain remain relatively unexplored. Here, we report that methylation at R198 and R200 of EGFR extracellular domain by protein …
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Epiregulin as a Novel Target for Antibody-Drug Conjugate Development for the Treatment of Colorectal Cancer
… conjugates (ADCs) are a fast-growing class of molecularly targeted therapies with 13 currently approved and over a 100 in clinical trials. ADCs consist of a monoclonal antibody (mAb) conjugated to a potent cytotoxic payload to selectively target tumor antigens highly expressed on the cell …
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Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of Glioma Tumor Initiating Cells
… imperative to identify the dysregulated molecular pathways which enable the maintenance of these cells in a stem-like state in order to inform strategies to therapeutically target them.</p> <p>In this study, we investigated the role of the Y705 and S727 phosphorylation domains of STAT3, a …
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Testing Whether MRP4 (a cAMP Efflux Pump) and the Beta 2 Andrenergic Receptor (an Upstream Regulator of cAMP Signaling Pathways
… protein may be responsible for holding the macromolecular complex of two proteins, MRP4 and !2AR. This association may be important for regulating cAMP levels in LNCaP cells and affecting the downstream expression of certain genes that depend on the cAMP signal transduction. </p>
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HP Turns 17: T helper 17 cell response during hypersensitivity pneumonitis (HP) and factors controlling it
<p>Hypersensitivity Pneumonitis (HP) is an interstitial lung disease caused by repeated inhalation of a wide range of environmental antigens. It is characterized by alveolitis, granuloma formation, and fibrosis. Since HP is a T cell-mediated disease, it is important to determine the type of T cell …
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