Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 162 for “"Medical Microbiology"”.
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Medical Microbiology: Discovery of New Antimicrobial Drugs to Treat Clinically Relevant Antibiotic Resistant Pathogenic Bacteria
Antimicrobial resistance (AMR) is one of the greatest world-wide threats to human health and urgent action is needed to reduce the potentially devastating social and economic impacts that may result from continued spread of drug resistant infections. These actions include discovery of new …
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Multizentrische Studie zur Antibiotika-Resistenz von Streptococcus pneumoniae bei nicht-hospitalisierten Patienten mit Infektionen des Respirationstrakts in Deutschland, 1998-1999
… pneumoniae were examined from 19 different medical microbiology laboratories. During the sensivity testing the following resistance rates were shown: penicillin G 6.6%; clarithromycin 10.6%; tetracycline 13.9%; and levofloxacin 0.1%. Only 2 of 126 tetracycline-resistant pneumococcal yielded …
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In vitro Recapitulation of the Polymicrobial Communities Associated with Cystic Fibrosis Airway Infections
… increasingly apparent within the field of medical microbiology. In part, these poorly understood interactions explain why, regardless of intense research efforts, therapeutic treatments designed to clear such chronic airway infections often fail within the clinical setting. The paucity of …
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Avaliação da atividade anti-Helicobacter pylori e citotóxica in vitro de extratos orgânicos obtidos das folhas de Encholirium spectabile e Syzygium cumini
… constituting an important microorganism in medical microbiology. Its importance comes from the difficulty of treatment because the requirement of multiple drugs use, besides the increasing emergence of resistant and multiresistant strains to antibiotics used in th e clinic. In order to …
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Phenotypic and molecular antifungal susceptibility testing of yeast isolates from Pretoria
… the diagnostic laboratory in the Department of Medical Microbiology at the University of Pretoria-National Health Laboratory Services. The isolates were subcultured on Sabouraud dextrose agar media for purity of yeast colonies. Identification to species level was performed using biochemical …
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Analysis of the genome organization and fitness traits of non-pathogenic Escherichia coli strain Nissle 1917 (O6:K5:H1)
… industrial and environmental biotechnology and medical microbiology – diagnostics and therapy, development of new drugs and vaccines against infectious agents. Together with the genomic approach, other molecular biological methods such as PCR, DNA-chip technology, subtractive hybridization, …
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Technical evaluation of a Real-time polymerase chain reaction (PCR) assay for the detection of Bartonella spp for diagnostic purposes
Infective endocarditis (IE) is a rare disease affecting heart tissues. The laboratory diagnosis of culture-negative endocarditis is complicated, and largely based on the combination of nucleic acid detection methods and serological investigation. There is a paucity of published data on microbes …
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Disabling the intrinsic resistome of Mycobacterium tuberculosis: elucidating hierarchies of DNA repair and mutagenesis that undermine current antibiotic efficacy
DNA damage repair mechanisms are critical to the adaptive evolution of Mycobacterium tuberculosis as obligate human pathogen, including the emergence of drug-resistance during anti-tuberculosis (TB) chemotherapy. In experimental models, DnaE2-dependent translesion synthesis (TLS) and UvrB-dependent …
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The utility of a real-time PCR to detect Leptospira in a routine diagnostic setting
Leptospirosis is a neglected zoonotic infection with world-wide distribution. A paucity of leptospirosis data from the African continent exists, mainly due to limited access to diagnostics. The clinical presentation ranges from mild to severe disease with multi organ involvement, while the mild …
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The Epidemiology and Evolution of Rifampicin Mono Resistant Tuberculosis in Khayelitsha, Cape Town, South Africa
Background: According to the World Health Organization Global TB report 2018, rifampicin monoresistant tuberculosis (RMR-TB) comprises 22% and 38% of all rifampicin-resistant TB (RR-TB) globally, and within South Africa, respectively. National surveys from South Africa show an increasing proportion …
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The bacteriome and metabolome of human breast milk and their association with infant growth
Human breast milk is a complex species-specific biological fluid universally known as the optimal postnatal source of nutrition for infants and therefore, recommended by the World Health Organization as the exclusive food for infants in the first six months of life. Despite the importance of human …
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Nasopharyngeal colonization dynamics with Streptococcus pneumoniae and associated antimicrobial resistance in a South African birth cohort
Introduction: Nasopharyngeal (NP) colonization by Streptococcus pneumoniae (the pneumococcus) precedes the development of respiratory tract infection. Colonization by antimicrobial-resistant pneumococci, especially in infants, is a major public health concern as pneumococcus is a frequent cause of …
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The development and evaluation of a polymerase chain reaction assay for the diagnosis of mycobacterium tuberculosis infections
The diagnosis of Mycobacterium tuberculosis by conventional techniques is associated with a number of problems which include lack of sensitivity (microscopy) and prolonged incubation periods (laboratory culture) . For these reasons various "rapid detection" methods have been developed but none of …
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CRISPRI-based high-throughput functional genomic approaches for use in mycobacteria
In the 20 years since the pioneering publication of the genome of Mycobacterium tuberculosis, significant efforts have been made to complete functional annotation of the genome. However, these efforts have generally been performed on a single-gene basis, ensuring slow progress and leaving large …
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The stool microbiota and infant wheezing illness - the Drakenstein child health study, South Africa
Background: Wheezing is one of the leading respiratory symptoms in childhood, which with recurrent occurrence can lead to asthma at school age. Few studies, with conflicting findings, have investigated the contribution of stool bacteria in childhood wheezing illness. Additionally, most of the …
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Association of Faecalibacterium, Lachnospira, Veillonella, and Rothia with childhood wheezing
Wheezing symptoms among children, present major health and economic problems globally. A recent study conducted in Canada observed a reduction in stool bacterial genera Faecalibacterium, Lachnospira, Veillonella and Rothia (FLVR) in three-month old infants with atopy-wheeze symptoms. It is not …
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Infectivity and pathogenicity of toxoplasma gondii in vitro and in vivo
While T. gondii (RH strain) infection in mice is always lethal, rats resist acute infection with a comparable dose and are generally considered resistant to T. gondii infection. IFN-y is found to play an important role in pathogenesis and infectivity in mice, though its role in the control of …
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Haemophilus influenzae adhesins and the innate immune response
Haemophilus influenzae is a human specific Gram-negative respiratory tract pathogen. Encapsulated H. influenzae strains exist in six different serotypes a-f, of which type b (Hib) is the most virulent. Hib is protected by the polysaccharide capsule when invading the blood circulaton and may cause …
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Real-time PCR for diagnosis of botulism and quantification of neurotoxin gene expression in Clostridium botulinum
The objectives of the work presented in this thesis have been to develop molecular methods for (i) detection of Clostridium botulinum in food and clinical samples, and (ii) monitoring the expression of the neurotoxin gene, cnt, during different growth phases and under different growth conditions. …
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Molecular studies on streptococcal surface proteins
Streptococcus agalactiae and Streptococcus pyogenes are two related human pathogens causing different diseases. This thesis focuses on a number of surface proteins expressed by S. agalactiae and S. pyogenes and, more specifically, the molecular and biological characterization of these proteins. The …
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