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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 99 for “"Medical Immunology"”.
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Host cell death in Legionella pneumophila pathogenesis and immunity
<p><em>Legionella pneumophila</em> is an intracellular pathogen that causes a severe, atypical pneumonia termed Legionnaires' disease. Upon entering the host cell, <em>L. pneumophila</em> resides in a membrane-bound vacuole, in which the bacterium evades lysosomal fusion and replicates. The …
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Defensins In Ocular Immunity
<p>Corneal infection with P. aeruginosa results in corneal perforation in susceptible</p> <p>B6, but not resistant BALB/c mice. This study explored their role mBD 1-4 in corneal</p> <p>infection, and their potential synergy. Immunostaining and real-time RT-PCR data</p> <p>demonstrated that their …
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Biochemical and Molecular Characterization of the Prostate-Specific Membrane Antigen (PSMA)
<p>Prostate cancer is the most common malignancy and the second leading cause of cancer death in males in the United States. Additionally, the number of deaths attributed to prostate cancer is increasing at a rate of approximately 8% a year. Development of new diagnostic and therapy strategies are …
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Immunologic Evaluation of Ectopic Gestation
<p>Ectopic gestation is an error in the implantation site of the blastocyst. Extrauterine implantation presents a unique environment since the protective features of the uterus are absent. This study is an investigation into the immunoregulatory differences that may develop as a result of a change …
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Lethatlity of and Elicitation of Protective Antibody by Vibrio parahaemolyticus ATTC 17803
<p>The LD<sub>50</sub> of Vibrio parahaemolyticus ATCC 17803 for 13- to 18-g male mice, strain ICR, as determined by the 50% endpoint method, was found to be an estimated 7 x 10<sup>7 </sup>CFU, when administered intraperitoneally in 0.5 ml of 24-h broth culture, O. D. 0.5 at 650 nm, diluted to …
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Dissecting the Relationship between Mucin 5AC and the Lung/Gut Microbiome in the Pathogenesis of K-ras Mutant Lung Cancer
<p>Non-small cell lung cancer, including its most common subtype, lung adenocarcinoma (LUAD), is the leading cause of cancer-related deaths worldwide. In LUAD patients, KRAS mutations are the most common oncogenic driver alteration. Given KRAS is upstream to many signaling pathways involved in cell …
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Characterization of a Novel Prostate Tumor-Associated Antigen
<p>The murine monoclonal antibodies (MAb) TURP-27 and HNK-1 have been shown to detect antigens that are heavily expressed by benign prostatic hyperplasia (BPH) and carcinoma of the prostate (CaP). Western blot analysis of prostate extracts, showed that MAb TURP-27 and MAb HNK-1 bound glycoproteins …
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Competitive Enzyme Immunoassay by Polyclonal Antibodies Against Organophosphorus Pesticides
<p>Organophosphorus compounds (OPs) comprise one of the major classes of pesticides in use today because they are highly effective and less toxic. Because of their extensive use, there is a need for monitoring OPs in water and vegetables. Gas chromatography (GC) is the usual method for OPs …
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Role of Mir-19A Released By Inflammatory Breast Cancer Cells In The Regulation of Dendritic Cell Functions: In Vitro Model of Crosstalk In The Tumor Microenvironment of Inflammatory Breast Cancer
<p>Inflammatory breast cancer (IBC) is a rare but very aggressive form of locally advanced breast cancer (1-6% of total breast cancer patients in United States), with a 5-year overall survival rate of only 40.5%, compared with 85% of the non-IBC patients. So far, a unique molecular signature for …
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Parp Inhibitor Upregulates Pd-L1 Expression and Enhances Cancer-Associated Immunosuppression
<p>With recent approvals for therapeutic antibodies that block CTLA4, PD-1 and PD-L1, immune checkpoints have emerged as new targets in cancer therapy. In addition, there is accumulating evidence highlighting the role of cancer-associated immunity in patient response to cytotoxic anticancer agents. …
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Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization
<p>"Influenza virus is a significant pathogen in humans and animals with the ability to cause extensive morbidity and mortality. Exuberant immune responses associated with immune cell migration/activation and cytokine/chemokine release, can be induced after infections. Recent studies have painted a …
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Interactions of Francisella Tularensis With Components of the Host Fibrinolytic System
<p><em>Francisella tularensis</em> (FT) is a Gram-negative coccobacillus and causative agent of a life-threatening disease commonly referred to as tularemia. Due to the highly infectious nature of the organism, its previous development as a biowarfare agent and its potential use in acts of …
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Gene Therapy Using Tet-Repressor System to Modulate Prostate Tumor Microenvironment
<p>Prostate cancer is the most commonly diagnosed malignancy in men in the United States and is projected to be the third most frequent cause of male cancer-related deaths in 2007 after lung and skin cancers. The initial treatment for prostate cancer at early stages is prostatectomy or radiation, …
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A Novel Syndecan-1 Targeted Therapeutic Antibody Inhibits Macropinocytosis and Induces Anti-Tumor Immunity in Pancreatic Cancer
<p>Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, with an overall 5-year survival rate of only 13%. Given the prevalence of oncogenic <em>KRAS</em> mutations (<em>KRAS*</em>) and their role in PDAC development and growth, therapeutic strategies to quench …
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Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity
<p>The tripartite motif-containing (TRIM) proteins have emerged as a new class of host antiviral restriction factors, with several demonstrating roles in regulating innate antiviral responses. Of >70 known TRIMs, TRIM56 inhibits replication of bovine viral diarrhea virus, a ruminant pestivirus of …
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The Expression Of Connexin-43 By CD11c+ Dendritic Cells Is Required to Maintain CD4+ Foxp3+ Regulatory T Cell Population in Peripheral Lymphoid Organs
<p>Foxp3<sup>+</sup> regulatory T cells (T<sub>R</sub>) are an immunosuppressive subset of CD4<sup>+</sup> T cells that maintain homeostasis of the immune system. They are sustained by the interaction between the Major Histocompatibility Complex (MHC) molecules present on antigen presenting …
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Telomerase Activity in Human Preimplantation Embryos
<p>Telomerase, a ribonucleoprotein, has been described as an essential component of highly proliferative cells, which stabilizes the telomeres and avoids cellular senescence. Telomerase has been identified in various embryonic cell stages, hematopoietic cells, and in >85% of tumor tissue biopsies …
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A COHORT STUDY INVESTIGATING AUTOANTIBODY LEVELS DURING AND AFTER INFECTION WITH INFLUENZA A VIRUS
<p>Antinuclear autoantibodies (ANAs) are present in all individuals. In those with autoimmune diseases they are routinely present in elevated levels. Although the nature and development of autoimmune diseases are not fully understood there are many hypotheses as to possible causes of an autoimmune …
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Investigating the role of the gut microbiota on immune checkpoint inhibitor-mediated colitis
<p>Immune checkpoint inhibitors (ICIs) have been revolutionary in the fight against cancer by recruiting the host immune system as an agent for attack on malignant cells. Unfortunately, immune-related adverse events (irAEs), including ICI-mediated colitis (IMC), are common side effects that result …
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