Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 147 for “"Medical Cell Biology"”.
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The c-Myc/TBX3/nucleolin/Hsc70 signalling axis in breast cancer
… TBX3 expression in MCF-7 breast cancer cells as well as (2) identify and characterize protein partners that cooperate with TBX3 to drive its oncogenic functions in these cells. The overexpression of the basic helix-loop-helix oncogenic transcription factor c-Myc has been widely reported …
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Myeloma-osteoclast interactions as a therapeutic target for multiple myeloma bone disease
… B lymphocytes, also known as plasma cells, which are cells specialized in generating antibodies. MM is responsible for 35,000 diagnoses and 13,000 deaths in the US annually. While both malignant and non-malignant plasma cells specifically migrate to the bone marrow, myeloma is often …
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Contribution of Ectodomain Mutations In Epidermal Growth Factor Receptor to Signaling In Glioblastoma Multiforme
… Using proteomic approaches to broadly analyze cell signaling, including antibody array and mass spectrometry-based methods, we found a differential spectrum of tyrosine phosphorylation across the EGFR ectodomain mutations that enabled us to stratify them into three main groups that correlate …
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Development Of Novel Breast Cancer Chemotherapeutics Directed Towards The Attenuation Of Metastatic And Chemo-Resistant Breast Cancer
… the rapid and uncontrollable proliferation of cells. These cells eventually become a mass, feeding off nutrients from other organs, eventually invading other organ systems and overtaking the body. Once cancer has reached this stage, surgical intervention is no longer effective, leaving other …
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Il-2 Regulation of Il-24 Expression Leads to Growth Suppression of Melanoma Cells
… mediated tumor growth suppression. Five melanoma cell lines were treated with high dose recombinant hIL-2 at 1000U/ml. Three of the cell lines (A375, WM1341, WM793) showed statistically significant increases in their levels of IL-24 protein when measured by Western blotting, while the remaining …
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Human oocytes and embryos viewed by time-lapse videography, and the development of an embryo deselection model
… namely reverse cleavage and less than 6 intercellular contact points at the end of the 4-cell stage, showing negative correlations with embryo implantation outcomes (Papers 5&6). A qualitative embryo deselection model was therefore proposed, including several qualitative measures with …
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Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia
<p>T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% of pediatric ALL cases and is associated with early relapse and inferior outcome. The poorer prognosis of T-ALL compared to B-precursor ALL may in part reflect the lack of unique features on which to base therapy. NOTCH1 mutations are …
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T-cell Receptor CDR3 Sequence but Not Recognition Characteristics Distinguish Autoreactive Effector and Foxp3+ Regulatory T-cells
<p>Regulatory T-cells (Treg) play an important role in maintaining immune tolerance to self-antigens and in suppressing excessive immune responses in the host. The source, specificity, and plasticity of the forkhead box transcription factor 3 (Foxp3<sup>+</sup>) Treg and conventional T (Tconv) cell …
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Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity
… most widely used anticancer agent; however, the cellular pharmacokinetics are poorly understood. Cisplatin is predominantly eliminated through the urine via active secretion and is associated with nephrotoxicity. Currently, prehydration therapy is employed to prevent toxic renal side effects; …
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Mechanically driven In vivo Osteocyte Ca2+ Signaling: Aging and Pharmacologic Effects
… is widely accepted that osteocytes are the key cells responsible for orchestrating the development of the “ideal” skeleton. This ability is attributed to osteocyte’s role as the primary mechanosensing cell that is responsible for maintaining the skeleton’s integrity throughout life. Recent work …
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Mechanisms of Cell Surface Trafficking and Potential Functions of Extracellular Annexin A2
… expressed in the cytosol of many different cell types and is translocated to the outer surface of the plasma membrane in response to elevated concentrations of intracellular Ca2+. It is known that the binding of Ca2+ to the C-terminal Ca2+-binding domains is essential for the recruitment of …
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Discovery of new biomarkers of mild cognitive impairment and Alzheimer's disease risk in buccal cells using laser scanning cytometry
… diagnostic to identify those who exhibit cellular pathology indicative of MCI and AD risk so that they can be prioritised for primary prevention. Human buccal cells are accessible in a minimally invasive manner, and exhibit cytological and nuclear morphologies that may be indicative of …
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Targeting The Redox System to Overcome Mechanisms of Drug Resistance In Chronic Lymphocytic Leukemia
… and is characterized by clonal expansion of B cells. The clinical course of CLL is diverse and nearly 50% of patients present with chromosomal abnormalities. Deletion of the short arm on chromosome 17 (del17p) occurs in 5-7% of cases and presents with the shortest median survival time and often …
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ASCL2 Positive Tumor Cells Modulate the Response of Metastatic Colorectal Cancer to MAPK-Targeting Therapy
… research is needed to determine the underlying biology limiting MAPKi therapy durability in CRC.</p> <p>In this project, we use a combination of patient-derived CRC models, clinical data, engineered models, molecular barcoding and next generation sequencing to elucidate novel mechanisms …
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Cellular Trafficking of Single and Multistage Vectors
… this study we investigated the intra and inter cellular trafficking of the multistage system in endothelial cells bringing evidence of its bio-compatibility as well as its ability to perform multiple intra and inter cellular tasks. Once internalized in cells, the multi-particle construct is able …
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Hematopoietic Stem Cell Threshold Sensing Controls Regulatory Pathways Facilitating Clinically Relevant Ex Vivo Expansion for Stem Cell Transplantation
<p>The ex vivo expansion of hematopoietic stem cells (HSCs) for transplantation has threefold importance: 1.) First, because of the rarity of stem cells there often isn’t a sufficient supply obtainable from common sources for larger children and adults. 2.) Secondly, patient morbidity and time to …
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Studying the Specificity of hPXR Antagonists Using a Panel of Cell-based Assays
<p>The pregnane X receptor (PXR or SXR; NR1I2) is a member of the nuclear receptor superfamily. It activates the transcription of a large network of genes including cytochrome P450 (CYP) and Mdr1 which play critical roles in chemicals metabolism and transportation. Induction of CYPs contributes to …
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Role of Extracellular Signal-Regulated Kinase (ERK) in Regulation of Intestinal Epithelial Tight Junctions
… tight junctions in differentiated Caco-2 cells, while it is disruptive to tight junctions in under-differentiated cells, and that in differentiated cells, ERK regulates the activity of PKCζ to enhance Thr-phosphorylation of occludin.</p> <p><strong>Specific Aims</strong>: 1. To determine …
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Platinum-NGR A Peptide Targeting Conjugate Of Cisplatin: Design, Synthesis, And Efficacy In Breast Cancer Cells
… of targeting moieties specific to cancer cell receptors. In this study we synthesized a platinum-Asn-Gly-Arg (NGR) peptide conjugate with a long-term goal of reducing adverse effects in patients, as well as combating possible drug resistance compared with other widely available …
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