Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Medical Biotechnology"”.
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Medical biotechnology law in South Africa : a human rights analysis of selected topics
… of the South African law on four topical medical biotechnology subjects, namely human embryo research, the use of human gametes, autologous tem cell therapy, and private stem cell banking. In all four cases, my analyses give specific prominence to two research themes: first, human dignity …
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Photoimmunotheranostic targeting of CSPG4-positive melanoma cells using SNAP-tag technology
Melanoma is one of the most aggressive and inherently resistant cancers and the most dangerous skin cancer. While it accounts for fewer than 5% of skin cancer cases, 80% of skin cancer related deaths are attributed to melanoma. While resection remains the gold standard for melanoma treatment, …
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Establishment of enhanced protein purification strategies for recombinant immunotherapeutics
Antibody-based diagnostic and therapeutic agents play a substantial role in modern medicine, particularly for cancer management. The use of monoclonal antibodies (mAbs) and their derivatives to fight cancer demonstrates a significant impact on both laboratory research and clinical applications. …
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Development of recombinant immunotoxins targeting overexpressed cell surface biomarkers trophoblast cell-surface antigen 2 and mesothelin for cervical cancer treatment
… cytotoxicity activity towards cancer cells. Medical Biotechnology & Immunotherapy Research Unit Institute for Infectious Disease & Molecular Medicine South African Research Chair in Cancer Biotechnology ETA represents the wild type (wt) of Pseudomonas exotoxin A, a highly cytotoxic protein …
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Factors affecting the excitability of skinned fibres of the rat
During the last decade, the rat mechanically skinned fibre preparation has been used with increasing frequency to investigate cellular aspects of excitation-contraction (EC) coupling processes in mammalian skeletal muscle. The main aim of this thesis was to increase awareness of factors that affect …
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Development of A Multi-Purpose Automated Synthesis Module For Production of Novel Pet Radiopharmaceuticals
<p>Among radiopharmaceuticals of positron emission tomography (PET), <sup>18</sup>F-Fluorodeoxyglucose (<sup>18</sup>F-FDG) made from commercialized automated synthesis module is the most frequently used in tumor diagnoses. But the false positive findings, such as infectious tissues and …
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A tailored biocompatible neural interface for long term monitoring in neural networks
Neural interface electrodes that can record from neurons in the brain for long periods of time will be of great importance to unravel how the brain accomplishes its functions. However, current electrodes usually cause significant glia reactions and loss of neurons within the adjacent brain …
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Feasibility study of trans-cranial Direct Current Stimulation in presence of Brain tumor
<p>Trans-cranial Direct Current Stimulation has been shown to modulate cortical neuronal activity. Weak constant current is applied to the scalp using electrodes, leading to sub-threshold changes in neuronal membrane potential. Before actual clinical stimulation is performed, such systems are …
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Adaptive defibrillator design
Defibrillators are medical equipments which are widely used to resume the normal pacemaking activities of the heart in patients with myocardivim abnormalities. Electrical defibrillation is usually achieved by passing an electrical current pulse transthoracically through the heart of the patient. …
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Synthesis of novel thyroid hormone analogues
A series of twenty two 2-phenoxybenzoic acids were prepared in various yields using two different methods. It was found that the method involving a modified Ullmann coupling of a phenol with 2-chlorobenzoic acid gave the best yields. Reaction between diphenyliodo-2-carboxylate and a phenoxide gave …
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Design and implementation of MEMS biomechanical sensors for real-life measurements of gait parameters
Foot clearance above the ground during walking is an important clinical and rehabilitation gait analysis parameter. Current bulky and laboratory environment based instruments are not suitable for measurement in the natural environment such as in the outdoors. This research analyses three promising …
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Anthropomorphic thigh for impact assessment
The aim of this investigation was to design and construct a prototype anthropomorphic thigh model which could assess the effectiveness of thigh protectors. This involved utilising data generated from living subjects and cadavers to select the soft tissue component of the model.
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Cellular Trafficking of Single and Multistage Vectors
<p>Nanomedicine is an innovative field of science which has recently generated many drug delivery platforms with exciting results. The great potential of these strategies rely on the unique characteristics of the devices at the nano-scale in terms of long time circulation in the blood stream, …
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Different Methodologies to Characterize and Diagnose Sickle Cell Disease in Both Developed and Developing Nations
<p>Sickle cell disease (SCD) is a genetic blood disorder that causes the RBC to become sickle shaped due to a mutation in the β-globin gene encoding the protein hemoglobin. This disease causes reduced oxygen carrying capacity of RBC resulting in painful crisis, hemolytic anemia, and infection …
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Trabecular Calcium Phosphate Scaffolds for Bone Regeneration
<p>Bone tissue engineering represents a strategy for the repair or regeneration of damaged bone in the body. The science underlying this clinical therapy bridges the traditional fields of cell biology, materials science and mechanical engineering with the aim to identify how cells behave on …
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Attachment Ability and Melanoma Inhibitory Activity mRNA Expression Level Changes in Murine B16-F10 Melanoma Cells Post Nanosecond Electric Pulses
<p>The effects of high-voltage nanosecond electric pulses (nsEPs) on metastatic melanoma are still unclear. Hence, we applied one, two, three, and four 300 ns 40 kV/cm pulses to murine B16-F10 melanoma cells. Cell attachment ability was determined by comparing the number of floating cells and the …
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Nanoparticles For Biomedical Applications
… the potential of three new nanoparticles for biomedical applications. With the rapid growth of the field of nanoscience, researchers have explored developing nanoparticles for various biomedical applications, including imaging, therapy, and drug delivery. This thesis demonstrates the development …
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Robotic Simulation of Disc Arthroplasty Surgery: Influence of Surgical Placement on Motion Segment Dynamics
<p>A variety of total disc replacement (TDR) designs exist for the treatment of disc pathologies. A key design parameter for a constrained ball and socket device is the location of the fixed center of rotation (COR). A previous study demonstrated that intact motion segment unit (MSU) mechanics and …
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Synthesis and Characterization of Methacrylated Hyaluronan-Based Hydrogels for Tissue Engineering
<p>Polymers have revolutionized the field of tissue engineering due to the countless possibilities of scaffolds that can be constructed from such a material. Through conjugation of other functional groups onto a polymer backbone, the mechanical properties of polymers can be controlled and has the …
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Targeting Oncogenic Mirnas With Small Molecules For Breast Cancer Therapy
<p><strong>The crucial role of microRNAs (miRNAs) in cancer pathobiology has driven the introduction of new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, there is a need to develop screening strategies that can target tumors in a specific way. Small …
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