Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"Medical Biophysics"”.
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Development of A Beam-Specific Planning Target Volume and A Robust Plan Analysis to ol For Proton Therapy
<p>Proton therapy is growing increasingly popular due to its superior dose characteristics compared to conventional photon therapy. Protons travel a finite range in the patient body and stop, thereby delivering no dose beyond their range. However, because the range of a proton beam is heavily …
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Automated to ols for Contour Review in Radiotherapy
<p>Peer review of organ-at-risk and target volume delineation is essential for patient safety and optimization of treatment outcomes. Peer review makes a substantial impact on patient outcomes, reporting notable rates of plan changes when reviewed and worse survival when patient cases are not …
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Influential Factors and Predicting Dose Delivery Accuracy for Imaging and Radiation Oncology Core’s Phantom Program using Machine Learning
<p>IROC’s mission is to help ensure consistent and comparable, high-quality radiotherapy across clinics that participate in national clinical trials. To obtain this mission, IROC’s phantom program provides a third-party end-to-end check of the clinical workflow of a patient receiving radiotherapy. …
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Quantifying The Magnitude of to tal Dose Deviation Caused By Various Sources of Error Among Iroc Phantom Irradiation Results
<p>The Imaging and Radiation Oncology Core (IROC) phantoms are used as an end-to-end test of an institution’s radiotherapy processes, and for clinical trial credentialing. Phantoms are treated like patients, and evaluation of the doses received by the thermoluminescent dosimeters (TLDs) inside the …
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Volumetric Modulated Arc Therapy Evaluation With The Radiological Physics Center Head and Neck Phantom
<p>Validation of treatment plan quality and dose calculation accuracy is essential for new radiotherapy techniques, including volumetric modulated arc therapy (VMAT). VMAT delivers intensity modulated radiotherapy treatments while simultaneously rotating the gantry, adding an additional level of …
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Development of Lineal Energy Spectrum-Based Biological Effects Models for Protons
<p>In this dissertation, methods are developed and described to allow for the rapid calculation of microdosimetric spectra (specifically, lineal energy) for protons. SuperTrack, a GPU-accelerated tool for calculation of microdosimetric spectra was developed and is capable of computing lineal energy …
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Encapsulated Contrast Agent Markers For Mri-Based Post-Implant Dosimetry
… brachytherapy treatment planning system; Varian Medical Systems, Inc., Palo Alto, CA), and found the dosimetry between both brachytherapy treatment planning systems to be comparable. To gain more insight into the MRI contrast characteristics of the Sirius MRI markers, I measured the Sirius MRI …
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Identifying The Immune Related Metabolic Properties of Pancreatic Cancer Using Nuclear Magnetic Resonance Spectroscopy and Dynamic Magnetic Resonance Spectroscopic Imaging With Hyperpolarized Pyruvate
<p>Despite its relatively low incidence, pancreatic cancer was the fourth leading cause of cancer-related death in the US in 2015. This is due in part to pancreatic cancer’s natural resistance to both chemotherapy and radiotherapy. Immunotherapy presents an attractive potential treatment approach, …
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Equipment to Address Infrastructure and Human Resource Challenges For Radiotherapy In Low-Resource Settings
… approach could reduce the additional number of medical physicists (the primary treatment planners) in LMICs by up to half. We used in-house algorithms including mutli-atlas contouring and quality assurance checks, combined with tools in the Eclipse Treatment Planning System®, to automate every …
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PIP2 Modulation of Afterhyperpolarizations in Magnocellular Supraoptic Neurons
<p>Magnocellular neurosecretory cells (MNCs) are large oxytocin (OT)- and vasopressin (VP)-releasing neurons that secrete these hormones into the circulatory system in response to physiological stimuli. These cells exhibit unique phasic and burst firing patterns to release these peptides into the …
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Beyond The Dvh - Spatial And Biological Radiotherapy Treatment Planning
<p><strong>Purpose</strong>: Both spatial and biological information are necessary in order to perform true optimization of a treatment plan and for predicting clinical outcome. The goal of this work is to develop an enhanced treatment plan evaluation tool which incorporates biological parameters …
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Evaluation of Artifacts In Experimental Cine 4D Ct Acquisition Methods
<p>Four-dimensional computed tomography (4D CT) has increased the accuracy of radiation treatment planning for patients in whom the extent of target motion is large. 4D CT has become a standard of care for radiation treatment simulation, allowing decreased motion artifacts and increased …
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Evaluation of Presage® Dosimeters For Brachytherapy Sources and The 3D Dosimetry and Characterization of The New Agx100 125I Seed Model
<p>With continuous new improvements in brachytherapy source designs and techniques, method of 3D dosimetry for treatment dose verifications would better ensure accurate patient radiotherapy treatment. This study was aimed to first evaluate the 3D dose distributions of the low-dose rate (LDR) …
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Investigation of Quatitative Image Features From Pretreatment Ct and Fdg-Pet Scans In Stage Iii Nsclc Patients Undergoing Defintive Radiation Therapy
<p>The purpose of this work was to determine if quantitative image features (QIFs) extracted from computed tomography (CT) and flourodeoxyglucose (FDG) positron emission tomography (PET) could provide prognostic information to improve outcome models. Our goal for this work was to determine if it …
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Development and Implementation of An Anthropomorphic Head & Neck Phantom For The Assessment of Proton Therapy Treatment Procedures
<p>Proton therapy has been used to treat cancer for more than 50 years, and over the past decade, its use has grown rapidly. One of the main goals of modern radiation therapy is to deliver a high dose to the planning target volume (PTV) with minimal exposure and damage to the surrounding healthy …
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Measurement of The Vascular Input Function In Mice For Dce-Mri
DCE-MRI is an important technique in the study of small animal cancer models because its sensitivity to vascular changes opens the possibility of quantitative assessment of early therapeutic response. However, extraction of physiologically descriptive parameters from DCE-MRI data relies upon …
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High-Throughput Mapping of The Biological Effects of Particle Therapy
<p>Radiation therapy is an essential tool in the cure of many cancer patients. Charged particle based radiation therapies are gaining momentum as the physical dose distributions of ions are superior to standard photons due their limited range. Additionally, charged particle radiation has been shown …
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Investigation of Respiratory Motion Management Techniques For Proton and Photon Radiotherapy of Lung Cancer
<p>Protons as a source of therapeutic radiation can provide a substantial improvement over dose distributions that can be achieved with conventional sources of radiation such as high-energy photons. However, respiratory motion can significantly impact the delivered proton and photon dose …
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Development of Low Frequency Electron Paramagnetic Resonance Methods and Instrumentation for Biological Applications
<p>EPR is a powerful biophysical tool that can be used to measure tumor physiology. With the addition of magnetic field gradients, the spectral properties of paramagnetic species can be mapped. To facilitate EPR imaging, methods and instrumentation at frequencies between 250 MHz and 1 GHz were …
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Volumetric, Magnetic Resonance-Visible, and Radiation-Sensitive Detectors For Magnetic Resonance Image-Guided Radiation Therapy
<h1>VOLUMETRIC, MAGNETIC RESONANCE-VISIBLE, AND RADIATION-SENSITIVE DETECTORS FOR MAGNETIC RESONANCE IMAGE-GUIDED RADIATION THERAPY</h1> <p>Hannah Jungeun Lee</p> <p>Advisory Professor: Geoffrey S. Ibbott, Ph.D.</p> <p>Due to the superior soft-tissue contrast of magnetic resonance imaging (MRI) …
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