Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 280 for “"Medical Biochemistry"”.
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Investigating nuclear transport proteins as secreted cancer biomarkers
Previous studies in our laboratory using microarray gene expression analysis identified members of the nuclear transport protein family as significantly upregulated in cervical cancer biopsies compared to normal cervical epithelial tissues. These results were validated at both mRNA and protein …
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To compare the expression, processing, incorporation and function of pseudoviruses and infectious molecular clones using different cell types and HIV backbones
Understanding HIV transmission mechanisms is essential for the design and development of an efficacious, broadly acting vaccine that targets features common to transmitted viruses. However, there is a lack of consensus amongst current HIV studies characterising transmitted founders (TFs). When …
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The relationship between p53 mutations and differential sensitivity to anti-cancer drugs in oesophageal cancer cell lines
In South Africa, cancer of the oesophagus is the leading cause of death in black males and overall the fourth most common cancer. Development of resistance to chemotherapeutic agents hinders the successful treatment of several cancers. In order to characterise drug resistance in several South …
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Investigating the effect of conventional chemotherapies, Cisplatin and Doxorubicin, in combination with a nuclear transport inhibitor, INI-43, on cerfical cancer cells
Background: Cervical cancer is the most common gynaecological cancer in South Africa, and the burden of disease remains high across the developing world. Like with many other cancers, treatment is limited due to drug resistance and adverse side effects. To overcome these limitations, it has become …
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Engineering nitrilases for enhanced thermostability
Cyanide dihydratase from Bacillus pumilus C1 (CynDpum) catalyses the hydrolysis of cyanide to formic acid and ammonia. CynDpum has the potential to remediate cyanide-containing wastewater. However, two obstacles hinder the commercial use of recombinantly expressed CynDpum as a biocatalyst: reduced …
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Characterisation of human surfactant protein A and recombinant human vimentin in their modulation of HPV16 pseudovirus infection
Infection by oncogenic human papillomavirus (HPV) is the primary cause of cervical cancer, where low-and middle-income countries (LMIC) have the highest incidence. Prophylactic HPV vaccines exist but LMIC have limited access. Therefore, alternative preventative measures against HPV infection and …
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Differentially expressed genes in oesophageal cancer
Oesophageal cancer (OC) is a leading cause of cancer death in the black population in South Africa. The lifetime risk of the disease amongst black males is 1 in 59. High incidence areas are the Transkei, Ciskei and KwaZulu-Natal where it is responsible for over 45 of all malignancies. Cancer …
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Investigating the Role of Cigarette Smoke and Alcohol in Oesophageal Squamous Cell Carcinoma
… is largely asymptomatic and patients often seek medical assistance at a late stage of their cancer. This late diagnosis and a lack of efficient treatment has rendered OC a serious world health problem. Oesophageal Squamous Cell Carcinoma (OSCC) is the more common subtype of and accounts for about …
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Characterisation of surfactant protein a as a novel prophylactic means against oncogenic HPV infections
Infection with Human Papillomavirus (HPV) presents a continuous global health challenge due to its incurable nature, particularly impacting low- and middle-income countries (LMIC). Although highly effective prophylactic vaccines targeting the most prevalent HPV types exist, they do not cover all …
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Characterisation of CIS- and trans-acting factors that regulate the human alpha 2(1) procollagen gene
The differential expression of the a2(I) procollagen gene in normal and transformed human fibroblasts has been correlated with differential in vitro DNA-protein interactions on the basal promoter region between -100 and -67. A 23 bp region of the a.2(1) procollagen promoter encompassing the G/CBE …
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The role of bacterial vaginosis-associated sialidase on HIV-1 infection
Studies suggest that women with Bacterial Vaginosis (BV) are at a higher risk of being infected by HIV-1. One possible reason is that bacterial vaginosis-associated bacteria (BVAB) release sialidases which alter either the virus and host cells directly or the viscosity of the female vaginal tract …
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The Rates of Glutathione Metabolism in Brain and Liver Studied with Glycine-2-C¹⁴
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Autodocking Studies of Oxygenated Fullerenes as Inhibitors of The HIV Protease
<p>In a previous study, several oxygenated fullerene compounds were produced by ozonation of C60 (Buckminsterfullerene) and were identified by elemental analysis and by SALI (surface analysis by laser ionization). Some of these compounds, especially a batch, SK-5, a mixture of C60O1-8, were shown …
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Plutonium pharmacokinetics and blood biochemistry
Since its discovery in the early 1940s the element plutonium has been seen by mankind as both an opportunity and a threat. As a radioactive nuclide plutonium presents health hazards in its handling and if mankind is to make the most of this element's potential benefits it is essential that these …
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Magnesium homeostasis in the mammalian heart
The magnesium ion (Mg2 ) is involved in a variety of physiological and biochemical processes including the activation of over 300 enzymes and the control of transmembrane movement of cations. In most mammalian cells intracellular Mg2+ is kept well below electrochemical equilibrium. In cardiac …
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Biochemical markers of hypertension and chronic renal failure in a Gulf Arab population of the United Arab Emirates
Hypertension is the commonest cardiovascular disorder and poses a major health challenge to populations of countries in socio-economic transition as well as those of developed countries. In the United Arab Emirates (UAE), hypertension has emerged as a leading cause of death. However, there is …
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Studies on the degradation of haemoglobin
The chemical relationship which exists between haemoglobin and bile pigments was first established in 1933, when, after monumental studies covering a period of 24 years, Hans Fischer and his colleagues succeeded in synthesizing bile pigments and protoporphyrin. He thereby demonstrated the …
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Proliferative and survival pathways in oesophageal cancer
Oesophageal squamous cell carcinoma (OSCC) is the 8th most common cancer worldwide with high incidence in areas that include China, Iran and South Africa. The current treatment available for OSCC does not significantly enhance patient survival. A better understanding of proliferative and survival …
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Modelling the transmission of tuberculosis
Airborne infectious diseases, such as tuberculosis (TB), are spread by airborne infectious particles (viable particles with potential for TB infection) in exhaled air from infectious individuals in enclosed spaces. Exhaled air is the carrier of airborne infectious particles and carbon dioxide is …
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Functional analysis of N-MYC downstream regulated gene 1 (NDRG1) in Oesophageal squamous cell carcinoma
Oesophageal squamous cell carcinoma (OSCC) ranks as one of the deadliest tumours with a high incidence in developing countries in the areas of Southern Africa, Middle East and Far East. Moreover, its unfavourable prognosis is further complicated by the lack of knowledge about the molecular biology …
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