Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"Mediated Release"”.
-
Cyclic stretch-mediated release of vascular endothelial growth factor by vascular smooth muscle cells : a role in improved vascular graft patency
… cyclic stretch has been shown to have on the release of other cytokines by SMC, this study investigates the role which cyclic stretch might play in VEGF expression by SMC in a compliant environment. Furthermore, following observations of receptor phosphorylation in response to cyclic stretch …
-
The role of reactive oxygen species in the endothelium derived hyperpolarising factor response
… The possibility that ROS are important for Ca2+ release from stores was examined by applying carbachol in Ca2+-free solution containing EGTA. Carbachol application then resulted in a transient [Ca2+]i increase that was reduced by SOD and catalase. The CYP 2C9 inhibitor sulfaphenazole (10 μM) …
-
Glia-neuron signaling
<p>This dissertation deals with release of neurotransmitter from glia. It has been demonstrated that bradykinin causes a receptor-mediated release of excitatory amino acids (EAAs), glutamate and aspartate, from glial cultures obtained from dorsal root ganglia (DRG) together with an increase in the …
-
The Role of EGFR Signaling in Gonadotropin-Induced Steroidogenesis
… to the mitochondria. Interesting, PKA-mediated transactivation of the EGF receptor occurs via both intracellular, ligand-independent signaling, as well as extracellular, ligand-dependent activation that requires Matrix Metalloproteinase (MMP)-mediated release of membrane-bound EGF …
-
The Mechanism of Assembly of the G-Protein Beta Gamma Subunit Dimer by CK2 Phosphorylated Phosducin-Like Protein and the Chaperonin Containing TCP-1
… In contrast, overexpression of PhLP caused the release of G-beta from CCT. This release was blocked by a PhLP S18-20A variant that lacks the S18-20 CK2 phosphorylation site. PhLP S18-20A has been previously shown to negatively affect the G-protein beta gamma dimer formation, suggesting a …
-
Inexpensive technologies enabling widespread utilization of image-predicated cell sorting
… or PACS, that permits the selective hydrogel-mediated photo-encapsulation of undesired cells in a culture dish and the retrieval of desired cells using enzyme-mediated release. The second is a method termed radical-activated cell sorting, or RACS, that permits the light-mediated killing of …
-
Spatial organization of sodium calcium exchanger and caveolin-3 in developing mammalian ventricular cardiomyocytes
… coupling is calcium-induced calcium release (CICR) mediated by L-type Ca2+ channels (Cav1.2). Briefly, membrane depolarization opens voltage-gated Cav1.2 to allow for the influx of extracellular Ca2+ into the cytosol. This small sarcolemmal (SL) Ca2+ influx is necessary for triggering …
-
A Molecular Mechanism for Endocytic Recycling of the M5 Muscarinic Acetylcholine Receptor
… of mammalian physiology. In the brain, MR-mediated neurotransmission is required for the control of movement and motivated behavior by the basal ganglia, and MR dysfunction may contribute to schizophrenia, Alzheimer's disease, and motor disorders. Functional studies of the muscarinic …
-
[Beta]-amyloid-mediated nitric oxide release from rat microglia by ligation of the integrin Mac-1
… on neuronal cells and direct [beta]-amyloid-mediated neurotoxicity, few have focused on the role of reactive glial cells in [beta]-amyloid-mediated neurotoxicity. In the present study nitric oxide release from cultured rat microglia was examined by exposing the cells to synthetic …
-
The Putative Role Of Fatty Acids In The Activation Of Trehalose Synthesis In The Fat Body Of The Cockroach Periplaneta Americana L
… stearic, oleic and linoleic acid. The hormone mediated release of these fatty acids is blocked by the PLA{dollar}sb2{dollar} inhibitors mepacrine and {dollar}rho{dollar}-bromophenacyl bromide. These observations suggest that hormonal release of fatty acids, may be due to the activation of …
-
Characterization of 5-Hydroxytryptamine-Evoked Isometric Contractile Responses in Aortic Vascular Smooth Muscle in Thyropathological Rats
… to completely antagonize the 5-HT2 receptor-mediated contraction. High concentrations of 5-HT in the presence of high concentrations of ICS 205-930, generated significantly attenuated contractile tension in rings from TRX rats. Conclusions. The elimination of a significant difference in the …
-
The Neurotoxicity of Insecticides to Striatal Dopaminergic Pathway
… I found that mitochondrial inhibitors are potent releasers of preloaded dopamine from striatal nerve terminals, with the most potent compounds active in the nanomolar range. Co-application of the K⁺ATP channel blocker glibenclamide selectively increased the dopamine-releasing effect by complex I …
-
Thermodynamic Investigations of Metalloproteins: Metal as Probe and Protein as Probe
… oxygen affinity at low pH, allowing for proton-mediated release of O<sub>2</sub>. This phenomenon, known as the Root Effect, serves as a proton-driven pump delivering O<sub>2</sub> to the swim bladders and eyes of the fish. The clam, ,<italic>L. pectinata</italic>, expresses functionally …
-
DEVELOPING CHEMICAL TOOLS TO MAP MOLECULAR MECHANISMS THAT DRIVE DISEASE
… we disclose a chemical tool that confers light-mediated release of a methylglyoxal probe within cell models. We use this chemical to identity of the resulting protein adducts. This work enables studying protein adducts induced by methylglyoxal in a controlled fashion to illuminate how this …