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Showing 1 to 20 of 79 for “"Mechanosensitive"”.
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Candidate mechanosensitive transduction channels in Drosophila melanogaster
… dass NompC ein essentieller Bestandteil der mechanosensitiven Transduktionsmaschinerie ist. Darüber hinaus haben wir Mutanten weiterer TRP Kanäle untersucht und konnten solche finden, die Funktionsweise von NompC modulieren.
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Mutations in a Mechanosensitive Channel Enable Intravascular Metaststic Cell Survival
<p>Next-generation sequencing technology has revolutionized cancer biology by accelerating the unbiased discovery of mutations across human cancers 1-4. Despite this advance, it remains unknown whether there exist mutations that function specifically to drive steps in the metastatic cascade …
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Modulation of mechanosensitive gastro-oesophageal vagal afferents by novel targets.
Modulation of signals from peripheral vagal afferent mechanoreceptors to the central nervous system has been identified as the most accessible target for control of neuronal pathways and reflexes central to gastrointestinal disorders such as GORD, disordered food intake and functional dyspepsia. …
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Determining Structural Transitions That Occur Upon Gating a Bacterial Mechanosensitive Channel
… can result in major trauma to the cell. The mechanosensitive channel of large conductance (MscL) is one of a handful of channels that responds to tension in the membrane and acts as a lifesaving mechanism for the cell in instances of osmotic down shock. Solutes are jettisoned before the cell …
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Molecular Dynamics Studies of the *Gating Mechanism of a Mechanosensitive Channel
Mechanosensitive channels are integral membrane proteins that gate in response to tension in the membrane. One such channel, MscL, poses an especially interesting challenge to modelers both because the channel is activated by membrane tension alone, and because the transition to the open state …
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Molecular Dynamics Studies Of The Gating Mechanism Of A Mechanosensitive Channel
Submitted by Meng Tao (mengtao2@illinois.edu) on 2012-10-12T23:59:36Z No. of bitstreams: 1 Gullingsrud.pdf: 9847446 bytes, checksum: d830d33e4dfe17fd16751f5656ebd512 (MD5)
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Exploring the Dynamics of Mechanosensitive Channels Utilizing a Post Translational Modification Approach
… and changes in osmolarity. The bacterial mechanosensitive channel of large conductance (MscL) and the mechanosensitive channel of small conductance (MscS), from E. coli, have been the most studied mechanosensors to date. These channels coordinate a response to rapid changes in osmolarity …
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Modelling of mechanosensitive morphogenesis and maintenance of cell structure: Application to musculoskeletal cells and tissues
… key steps towards an analytical understanding of mechanosensitive morphogenesis and structure maintenance in biological systems. In order to make this problem tractable and to make a significant advance during the PhD, I focussed specifically on musculoskeletal applications of mechanosensing. My …
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Hyperactive Rac1 Drives MAPK-Independent Proliferation in Melanoma by Assembly of a Mechanosensitive Dendritic Actin Network
… These data suggest an alternative mechanism for mechanosensitive growth regulation that can be hijacked by cancer cells to circumvent the adverse conditions of foreign microenvironments or drug treatment.
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Regulation of Functional Expression of Mechanosensitive Trpv4 Channel In The Distal Nephron By Dietary Potassium and Sodium Intake
<p>The Ca<sup>2+</sup>-permeable TRPV4 channel is predominantly expressed in the distal nephron (DN) and its activity is essential for [Ca<sup>2+</sup>]<sub>i</sub> elevations in response to increased tubular flow. Here, I probed the physiological mechanisms controlling TRPV4 function and …
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Molecular Basis of Mechanosensitivity
… is thought to be the opening or closing of mechanosensitive channels, but the clonal nature of the first mechanotransducers is still largely unknown. The objective of my research was to identify molecules involved in mechanosensory transduction by both studying known channels as well as …
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Intrinsic Neural Control of Propulsion, Storage and Slow Transit in the Large Intestine.
… CM, in close opposition to the myenteric plexus. Mechanosensitive ion channels present on the sensory elements are likely to be responsible for the transduction of the circumferential stretch.In the guinea pig distal and primate sigmoid colons, application of longitudinal stretch inhibited all …
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Regulation of PIEZO Channels by Membrane Lipids
… gene expression. Among such protein complexes, mechanosensitive ion channels stand out as the quickest mechanotransductors, as they can generate physiologically relevant responses to mechanical cues, on a millisecond timescale. Mechanosensitive ion channels are transmembrane proteins that …
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Mechanical regulation of cell-cell junctions
… that type I classical cadherin complexes are mechanosensitive. Mechanical forces in the tissue environment play a profound role in the growth, morphogenesis, and physiology of cadherin-expressing cells. In order to establish how force impinges on critical cell functions in healthy or diseased …
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Slow Touch and Fast Nociception: Exploration of the Interactions Between Noxious and Innocuous Mechanical Touch Sensation
… stimuli are encoded by cutaneous low threshold mechanosensitive receptor (LTMR) endings, innervated by fast conducting, thickly myelinated Aβ afferent nerves (Mountcastle, 2005). In contrast, higher force, potentially tissue damaging, mechanical stimuli are, according to this view, encoded by …
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Assessing the Role of the Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channel in Visceral Sensation
… mice with colitis. Isosakuranetin inhibited the mechanosensitive response to distension of wide-dynamic range afferent nerve units from mice with colitis but had no effect in healthy mice. Therefore, TRPM3 protein is expressed in colon-projecting DRG neurons and functionally expressed in colonic …
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Molecular mechanisms of gating and selectivity in transport channels
… The nuclear pore complex (NPC), and the mechanosensitive channel of small conductance, MscS are the focus of the research presented in this thesis. NPCs are sole gateways for passage of material across the nuclear envelope of eukaryotic cells. Several unstructured proteins that are rich …
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Molecular and Cellular Mechanisms of LIM Protein Mechanotransduction
… and tested the hypothesis that LIM proteins are mechanosensitive actin binding proteins. Using an imaging-based screen of mechanically-stretched fibroblasts, I identified the zyxin, FHL, and paxillin families of tandem LIM domain proteins to be mechanoresponsive cytoskeletal proteins. A single …
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Development of a Generalizable Assay for Probing the Effects of Mechanical Force on the Function of Fluorescent Proteins within Molecular Tension Sensors
… elucidating the molecular processes underlying mechanosensitive regulation, molecular tension sensors (MTSs) have been created to measure forces experienced by specific proteins inside cells. However, an incomplete understanding of the effects of intracellular forces on fluorescent protein (FP) …
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