Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Mechanosensing"”.
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Enabling Soft Mechanosensing via Vat Photopolymerization 3D Printing: Materials, Design and Integration
L'abstract è presente nell'allegato / the abstract is in the attachment
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The Role of the Discoidin Domain Receptor-1 (DDR1) in Vascular Smooth Muscle Cell (VSMC) Mechanosensing
Mechanotransduction is the process by which extracellular physical cues are converted into intracellular biochemical responses. The stiffness of the matrix influences numerous processes such as cell differentiation, cell migration, fibrosis, and tumorigenesis. Stiffness is sensed by matrix-binding …
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Interplay between Piezo1-mediated mechanosensing and the chemical guidance cue Semaphorin3A during development of the embryonic nervous system
… out to determine if tissue stiffness, cellular mechanosensing, or both were affected by Piezo1 downregulation. Knocking down Piezo1 softened brain tissue, suggesting that the axons were encountering an environment with altered mechanical properties, and therefore mechanical signalling was …
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Biophysical and biochemical factors in the cellular microenvironment; effects on cell migration and invasion
… locally applied mechanical stimuli and how this mechanosensing is regulated. Would the regulation be different if cancer cells were to sense the applied stimulus? Studies have shown that as cells migrate they produce contractile forces called traction forces that are generated by the cellular …
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Mathematical modelling of motility regulation in Myxococcus xanthus
… focusing on contact-dependent reversal control, mechanosensing response and impact of motility regulation in solitary (single-cell) predation. My goal is to provide experiment-guiding theories and hypotheses for M. xanthus motility regulation, which is essential to fully understand the social …
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Influence of Extracellular Matrix Stiffness and Topography on Neuronal Cell Behavior and Neurite Outgrowth
… transfers higher stress to the ECM, known as mechanosensing. The mechanosensing, however, approaches saturation at a threshold ECM stiffness and is impacted by ECM thickness, topography, integrin and NCAM clustering. Furthermore, a cylindrical ECM asperity results in asymmetric stress and …
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Investigating the role of calcium in the biomechanical response of neutrophils to mechanical deformation experienced in the pulmonary capillaries
… pathways, yet little is known about the mechanosensing signaling involved. Other work has demonstrated that physiological deformation of neutrophils induces a marked increase in the levels of cytosolic calcium, suggesting that this occurrence may trigger the biomechanical response …
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PROBING CELLULAR MECHANO-SENSITIVITY USING BIOMEMBRANE-MIMICKING CELL SUBSTRATES OF ADJUSTABLE STIFFNESS
… However, the underlying mechanisms of cellular mechanosensing still remain a topic of open debate. Traditionally, advancements in this field have been made using polymeric substrates of adjustable stiffness with immobilized linkers. While such substrates are well suited to examine cell adhesion …
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Understanding the adhesome network in primary and metastatic cutaneous squamous cell carcinoma
… that Mena may act as a molecular clutch for the mechanosensing function of Nesprin-2 with actin. The putative molecular clutch activity of Mena regulates the phosphorylation of EMERIN and possibly affects histone methylation. Here, we propose a novel mechanism by which Mena may regulate …
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Genomic Approaches to Congenital Genitourinary Disorders
… mutation impairs muscle cell contraction and mechanosensing. Candidate genes identified from sequencing the exomes of unrelated patients are hypothesized to have similar effects on cellular function, suggesting a common causative pathway may contribute to PBS pathogenesis. Additionally, …
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Hyperactive Rac1 Drives MAPK-Independent Proliferation in Melanoma by Assembly of a Mechanosensitive Dendritic Actin Network
… We describe an alternative arm for cell mechanosensing, whereby actin polymerization against a matrix of minimal rigidity organizes biochemical cues to drive proliferative signals. Hyperactivation of Rac1 by the P29S mutation channels this pathway in melanoma through Arp 2/3-dependent …
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Force-induced calcium concentration change and focal adhesion translocation : effects of force amplitude and frequency
… environment. In order to examine the rapid mechanosensing thresholds involved with mechanotransduction, calcium concentration changes and focal adhesion site translocations were observed with fluorescent microscopy by labeling intracellular calcium with Fluo-3 calcium dye and by infecting …
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INVESTIGATING THE ROLE OF LIPID DROPLETS AS INTRACELLULAR MECHANICAL STRESSORS IN NON-ALCOHOLIC FATTY LIVER DISEASE
… sources of mechanical stress can impact nuclear mechanosensing and gene expression.
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Cell culture platforms with cell-cell adhesive ligands for biomedical applications
… fragments on mesenchymal stem cell (MSC) mechanosensing and paracrine function. Chapter 3 explores how recombinant N-cadherin protein coated on different surfaces can instruct the formation of neural networks. Finally, Chapter 4 investigates the influence of N-cadherin on the secretion of …
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Structural Stiffness Gradient along a Single Nanofiber and Associated Single Cell Response
… importance of structural stiffness in cellular mechanosensing at the single cell-nanofiber scaled warrants consideration of the above factors in accurate design of scaffolds in future.
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Probing cellular mechano-sensitivity using biomembrane-mimicking cell substrates of adjustable stiffness
… However, the underlying mechanisms of cellular mechanosensing still remain a topic of open debate. Traditionally, advancements in this field have been made using polymeric substrates of adjustable stiffness with immobilized linkers. While such substrates are well suited to examine cell adhesion …
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Activation processes in biology
… problem is related to the biological process of mechanosensing, when the unfolding `sensor' protein exposes catalytic residues and generates a chemical signal to the cell. Related to this is the analysis of population-dynamics study of cells adhesion on substrates, which allows me to extract key …
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α7β1 integrin regulation of skeletal muscle growth in response to mechanical stimulation
… provide a novel approach towards maintenance of mechanosensing and the anabolic response across the lifespan. These observations in mice provide impetus for assessment of the relationship between extracellular matrix protein composition and subsequent α7β1 integrin-mediated remodeling within …
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Single Cell Force Platforms to Link Force-ECM Coupling in Pathophysiology
… of forces. These dynamic interactions facilitate mechanosensing, critical to fundamental biological processes in pathophysiology. Naturally, the field of mechanobiology has evolved over the past several decades to decipher the role of forces in mechanotransduction using a variety of …
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Effects of substrate stiffness on bacterial biofilm formation
… results suggest that motB may play a role in mechanosensing of material stiffness by E. coli. Similarly, mutation of oprF in P. aeruginosa also caused major defects in response to PDMS stiffness and abolished the difference in adhesion, growth, morphology and antibiotic susceptibility of …
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