Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"Mechanobiology"”.
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Mechanoprobe fabrication and development for mechanobiology
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Engineering approaches to study lung mechanobiology
Engineering tools and techniques greatly expand the scope of biological studies, permitting investigation of the interplay between mechanical forces, and cell and tissue biology, and also enabling in vitro replication of the physiological environment. This dissertation describes the development of …
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Mesenchymal Stem Cell Mechanobiology and Tendon Regeneration
Tendon function is essential for quality of life, yet the pathogenesis and healing of tendinopathy remains poorly understood compared to other musculoskeletal disorders. The aim of regenerative medicine is to replace traditional tissue and organ transplantation by harnessing the developmental …
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Suspended Micro/Nanofiber Hierarchical Scaffolds for Studying Cell Mechanobiology
Extracellular matrix (ECM) is a fibrous natural cell environment, possessing complicated micro-and nano- architectures, which provides signaling cues and influences cell behavior. Mimicking this three dimensional environment in vitro is a challenge in developmental and disease biology. Here, …
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Scleraxis-mediated regulation of tendon and ligament cell mechanobiology
… for future studies of tendon and ligament mechanobiology.
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INTRACELLULAR FORCES AND NUCLEAR MECHANOBIOLOGY DURING CONFINED CELL MIGRATION IN 3-DIMENSIONS
Cell migration is a required step in many biological and pathological processes. During wound healing, embryogenesis, and immune surveillance, cells migrate to sites where they can repair, develop, and protect tissues, which are all essential for maintaining healthy physiology. In contrast, during …
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The mechanobiology of the T-Cell Receptor: Structurally connecting catch bonds with ligand binding and triggering
The mechanism of the recognition of antigens and the activation of CD3 signaling domains by the T-Cell Receptor (TCR) are studied. The first part is focused to investigate how the information encoded in the peptide is decoded mechanically by the TCR and what is the structural role of catch bonds. …
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Cartilage mechanobiology : the effects of loading on the fine structure and function of chondroitin sulfate glycosaminoglycans
Chondroitin sulfate is a critical component of articular cartilage due to its contribution to the tissue's resistance to compressive deformation. Alterations in the biosynthesis of this molecule over time could impact the ability of the tissue to perform its necessary functions. Several factors …
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Cartilage mechanobiology and transcriptional effects of combined mechanical compression and IGF-1 stimulation on bovine cartilage explants
Background: Investigators have focused on mechano-regulation of upstream signaling and responses at the level of gene transcription, protein translation and post-translational modifications. Intracellular pathways including those involving integrin signaling, mitogen activated protein kinases …
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Shape Memory Polymers as 2D Substrates and 3D Scaffolds for the Study of Cell Mechanobiology and Tissue Engineering
… their potential as platforms to study cell mechanobiology and as functional tissue engineered constructs.</p> <p> The first part of this dissertation describes the fabrication and application of an SMP bilayer system capable of forming nano-scale wrinkles under cytocompatible conditions. …
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Mechanobiology of the nucleus pulposus: The effect of hydrostatic pressure and glucose deprivation on nucleus pulposus cell sub‐populations
The nucleus pulposus of the intervertebral disc contains two cell types: notochordal (NC) and chondrocyte‐like mature nucleus pulposus (MNP) cells; the ratio of which changes with species, age and health. Intervertebral disc (IVDs) that contain predominantly MNP cells are susceptible to …
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Enhancing Chondrocyte Biosynthetic Activities: Harnessing the Power of Loading-Induced Evolved Temperature
… in vitro investigation of cartilage thermo-mechanobiology, this thesis unearths the hidden influence of temperature increase on this exquisite tissue, shedding new light on the complex interplay between mechanical and thermal stimuli on chondrocyte function. Employing a biomimetic approach, …
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A NOVEL DROPLET-BASED PLATFORM FOR TUMOR SINGLE-CELL ENCAPSULATION AND METASTATIC MULTICELLULAR CLUSTER MODELLING
… of engineering microfabrication and cancer mechanobiology, offering a scalable and physiologically accurate model to study the dynamic behaviours of tumour clusters under biomechanical stress conditions.
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Single Cell Force Platforms to Link Force-ECM Coupling in Pathophysiology
… in pathophysiology. Naturally, the field of mechanobiology has evolved over the past several decades to decipher the role of forces in mechanotransduction using a variety of force-measurement platforms. A central challenge that has yet to be overcome in the field is connecting forces with the …
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Hypergravitational stimulation of cell differentiation
Mechanobiology is an emerging field within biophysics which encapsulates cellular responses to mechanical stimuli. Mechanotransduction is the highly dynamic and varied downstream cellular signalling which is activated through many different modes of mechanical stimulation. Control of stem cell …
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Role of biomechanics and tumor microenvironment in osteosarcoma progression
… under the themes of tumor heterogeneity, mechanobiology and the tissue microenvironment. It aims to understand the different influences, physical and biochemical, present in the osteosarcoma tissue microenvironment and connect them to give a broader understanding of the tumor …
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Hierarchical Assembly of Polymeric Nanofibers for Advanced Material Applications
… and apoptosis provides new insights in cell mechanobiology.
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STUDY OF THE MUTUAL INTERACTION BETWEEN EXTRACELLULAR MATRIX AND CELLS IN PERITONEAL METASTASIS
This thesis project is related to the field of mechanobiology, a novel and emerging area of biology. The work is mainly focused on the biomechanical interaction of cancer cells with extracellular matrix extracted from human patients during peritoneal metastasis. AFM microscopy with large colloidal …
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INVESTIGATING THE ROLE OF LIPID DROPLETS AS INTRACELLULAR MECHANICAL STRESSORS IN NON-ALCOHOLIC FATTY LIVER DISEASE
… are also broadly applicable to the field of mechanobiology, as we have shown that internal sources of mechanical stress can impact nuclear mechanosensing and gene expression.
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