Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"Mechanistic Investigation"”.
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Mechanistic Investigation of A Hemostatic Keratin Biomaterial
Traumatic injury leads to more productive years lost than heart disease, cancer and stroke combined. Trauma is often accompanied and complicated by uncontrolled bleeding. Human hair keratin biomaterials have demonstrated efficacy in controlling hemorrhage in both small and large animal models; …
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Synthetic and Mechanistic Investigation of Alpha-Amido Carbanions
The removal of an sp('3) proton from a carbon adjacent to nitrogen followed by reaction with an electrophile to effect substitution at that site provides umpolung of the customary amine polarity. This thesis reports the use of a carbonyl moiety to aid in the stabilization of negative charge …
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Mechanistic Investigation of FCC CO/NOx Emission Control Additives
<p>Fluid Catalytic Cracking (FCC) is the primary process used to convert crude oil into a variety of higher-value products in modern petroleum refineries. Some portion of the nitrogen present in crude oil feeds is transported - as part of the coke formed during the cracking process - into the FCC …
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Mechanistic investigation of human cytochromes P450 involved in hormone biosynthesis
… for certain breast cancers. To interrogate mechanistic aspects of both these enzymes, I used Nanodisc technology for reconstituting active forms of these proteins in functional complexes with their effector proteins in a native-like membrane environment. Cytochrome P450 17A1 (CYP17A1) is a …
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Mechanistic Investigation of Genotype-Phenotype Correlations in PIK3R1-Related Diseases
The PIK3R1 gene encodes three proteins - p85$\alpha$, p50$\alpha$ and p55$\alpha$ - that are regulatory subunits of Class IA phosphoinositide 3-kinases (PI3Ks). These regulatory subunits heterodimerise with one of three catalytic subunit isoforms, namely p110$\alpha$, p110$\beta$, or p110$\delta$. …
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Structural and mechanistic investigation towards the regulation of M.tb isocitrate lyase
… the regulation of ICL from structural and mechanistic perspectives. In particular, it focuses on the inhibition of M. tb ICL by the human macrophage metabolite itaconate, and the activation of M. tb ICL2 by lipid metabolite acetyl-coenzyme A (acetyl-CoA) and its structural analogues. The …
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Development and Mechanistic Investigation of Indium(III)-Catalysed Hydrosilane Reduction of Imines
… work has been combined with computational investigations of potential complexes and mechanistic pathway calculations. The most plausible pathway, established from the computational investigations presented in this thesis, proceeds via the formation of an In(III)-hydride species. This …
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Mechanistic investigation of coordinated conformational changes in multisubunit ion channels and enzymes
… protein activity. This dissertation describes investigations of coordinated conformational changes in two systems: the ATP-sensitive potassium (KATP) channel and the ATP-dependent bacterial protease, ClpAP. KATP channels consist of two protein subunits: a pore-forming subunit, Kir6.2 and a …
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Mechanistic Investigation into the Regulation of Amyloid Motifs in Tau Aggregation and Disease
Amyloid formation of tau protein is a unifying theme in a multitude of neurodegenerative diseases, collectively called tauopathies. Missense mutations in the tau gene (MAPT) correlate with aggregation propensity and cause dominantly inherited tauopathies, but the molecular mechanism of how they …
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A mechanistic investigation of nonlinear interfacial instabilities leading to slug formation in multiphase flows
… carries out both theoretical and computational investigations of some nonlinear mechanisms governing the interfacial stability and nonlinear evolution of stratified two-phase flows through horizontal channels and pipes. The resulting investigation identifies a strong nonlinear energy transfer …
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Mechanistic investigation of skin barrier perturbation induced by surfactants in the presence of humectants
… objective of this thesis was to develop a mechanistic understanding, including visualization and quantification, of: (i) how aqueous surfactant solutions, once in contact with the skin, can induce skin barrier perturbation, and (ii) how surfactant-induced skin barrier perturbation can be …
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Mechanistic investigation of anticancer agents that damage DNA and interact with the estrogen receptor
… in tumor cells. My dissertation focuses on the mechanistic studies of the rationally designed genotoxicants E2-7aX and 2Pl, which target cancer cells that express the estrogen receptor (ER). The studies on the biological activity of E2-7ca in ovarian cancer cells reveal that the compound induces …
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Mechanistic investigation of an anticancer agent that damages DNA and interacts with the androgen receptor
The 11[beta] molecule comprises a ligand for the androgen receptor (AR), which is crucial to progression and survival of many prostate cancers, tethered to a DNA-damaging aniline mustard. The compound was designed to exhibit selective toxicity toward prostate cancer cells by forming sites of …
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Formal Insertion Reactions Of Stannylenes And Germylenes Into Phosphorus-Halogen Bonds: A Structural And Mechanistic Investigation
… were employed to examine the possible mechanistic pathways. All reasonable pathways for these reactions are discussed, analyzed and compared. Additionally, as most tin-containing insertion products are unstable, the likely mechanisms for their decomposition are discussed in detail.</p>
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Synthetic and mechanistic investigation of new radical processes: reaction of organic azides with group-XIII Lewis acids
Dichloroindium hydride revealed to be a valid alternative to tributyltin hydride for radical reduction of organic (alkyl, aryl, acyl, solfonyl) azides. The new approach entails mild reaction conditions and provides high yields of the corresponding amines and amides, also showing high degrees of …
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Development and Mechanistic Investigation of the Palladium-Catalyzed Alpha-Arylation of Aldehydes and N-Arylation of Ammonia
… ammonia, and acid chlorides or anhydrides. Mechanistic studies showed that reactions conducted with the combination of CyPF t-Bu and Pd[P(o-tol)3]2 as catalyst occur with faster rates and higher yields than those conducted with CyPF-t-Bu and palladiun(II) as catalyst precursors.
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Development and mechanistic investigation of the palladium-catalyzed α-arylation of aldehydes and N-arylation of ammonia
… ammonia, and acid chlorides or anhydrides. Mechanistic studies showed that reactions conducted with the combination of CyPF-t-Bu and Pd[P(o-tol)3]2 as catalyst occur with faster rates and higher yields than those conducted with CyPF-t-Bu and palladiun(II) as catalyst precursors.
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Mechanistic investigation of polyhydroxybutyrate (PHB) synthases and elucidation of PHB biosynthesis and degradation process in Wautersia eutropha H16
… with the wt synthase at S/E ratios of 70,000 was mechanistically informative.
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High oxidation state molybdenum and tungsten imido alkylidene and metallacycle chemistry : catalytic asymmetric olefin metathesis and mechanistic investigation
Enantiomerically pure molybdenum imido alkylidene complexes of the type Mo(NAr)(CHCMe₂Ph)[Ar'](THF), which contained 3,3'-diaryl (Ar' = Mes (21), Ph (22)) substituted binaphtholate ligands, were prepared and structurally characterized. Complex 21 was a trigonal bipyramidal anti alkylidene complex; …
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