Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 245 for “"Mechanistic Insights"”.
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Mechanistic Insights Into Vancomycin Resistance In Clostridioides Difficile
<p><em>C. difficile </em>is a nosocomial, opportunistic pathogen that has become more hypervirulent over the last decade. Vancomycin is currently a frontline antibiotic for the treatment of <em>C. difficile</em> infections. Yet, strains of <em>C. difficile</em> are becoming non-susceptible to …
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Mechanistic insights into the aggregation of [beta]-amyloid
… methodologies were developed in order to provide mechanistic insights into A/3 amyloid formation. In Chapter 3 the optimisation of an A/3 purification methodology was achieved, greatly improving the reproducibility and purity of the samples obtained. This methodology was then applied to the …
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Myosin structural dynamics: mechanistic insights and therapeutic technology developments
… these experiments reveal new and important mechanistic insights into myosin’s structural dynamics and provide proof-of-concept results for developing therapeutic technology.
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Mechanistic insights into the secondary-active multidrug transporter LmrP
… are interpreted in a structural context, and a mechanistic model is presented for the transport of divalent cationic propidium and monovalent cationic ethidium. I also established an antibiotic binding assay to assess conformational changes in LmrP. The results show that the binding affinity for …
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Coherent Dynamic Nuclear Polarization: Mechanistic Insights and Experimental Advances
… under off-resonance driving. Building on these insights, we developed a general framework for analyzing amplitude-, phase-, and frequency-modulated pulses. This approach enables the design of hybrid pulse sequences that combine modulation and chirping to produce efficient, selective spin …
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Mechanistic Insights into the Effects of Exercise on Inflammatory Responses
Despite the importance of the inflammatory response in fighting infections, prolonged or unwanted inflammation is the root cause for serious human diseases including atherosclerosis and cancer. Therefore, understanding how inflammation is regulated is crucial for preventing these diseases. The …
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Structural and Mechanistic insights into Centromere Specification and Kinetochore Regulation
Faithful transmission of the genome requires that chromosomes are accurately segregated between daughter cells in mitosis. Accurate chromosome segregation relies on proper specification of the site of kinetochore formation on each chromosome, in addition to dynamic regulation of the interactions of …
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Mechanistic Insights into the Notch signalling pathway through Molecular Condensation
The ability of a cell to undergo cellular decisions is ingrained in the integration of cues from its local environments. One such cue is relaying information based on local cell density, neighbouring cell identity, and cell positional information. A key signalling pathway in interpreting this …
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Protein-protein interactions and mechanistic insights for CYP2J2 and CYP5A1
Eicosanoids are signaling molecules formed from the oxidation of -3 and -6 fatty acids. CYP2J2 and CYP5A1 are two key enzymes involved in the formation of eicosanoids. CYP2J2 is a classical P450 which requires transfer of electrons from its obligate redox partner, cytochrome P450 reductase (CPR). …
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Bacteria - Hydrogel Interactions: Mechanistic Insights via Microelastography and Deep Learning
… this thesis proposes a trident approach towards mechanistic understanding of bacteria motility in time-invariant agar and temporally evolving collagen hydrogels to bridge critical gaps in understanding bacterial motile behavior in these media, non-destructive microelastography-based mechanical …
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Mechanistic Insights into MftR-Dependent Regulation of the Redox Cofactor Mycofactocin
… that require MFT is not well-understood. To gain insights into the regulation of MFT in <em>Mycobacterium smegmatis</em> mc2155, we investigated the DNA-binding and ligand-binding activity of the putative TetR-like regulator, MftR. Here, we demonstrated that MftR binds to the <em>mft</em> promoter …
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On transient assemblies in amyloid formation: mechanistic insights and therapeutic strategies
… species, providing previously unattainable insights into their features that confer toxicity in disease pathology. I then investigate the mechanisms of oligomer formation and dissociation in protein aggregation reactions. Through a combination of kinetic assays and single-molecule …
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Microbial Dynamics and Mechanistic Insights into a Hydrogenotrophic Denitrifying Microbial Consortium
The current heterotrophic denitrification processes predominantly used in wastewater treatment plants can lead to the fugitive emission of greenhouse gases (N2O and CO2). This is due to microbial competition for limited organic electron donors such as methanol and acetate. Recently, autotrophic …
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Mechanistic insights into how collective effects mediate the T cell response
… theoretical paper and experiments, a generalized mechanistic framework has emerged over the past decade to describe the remarkable robustness of self/non-self discrimination in spite of the presence of autoimmune T cells in every host. This quorum threshold mechanism states that a threshold number …
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Biologically Interpretable Representation Learning for Mechanistic Insights into Cancer Immunotherapy Resistance
… deep learning framework designed to uncover mechanistic drivers of ICI resistance through multi-omic data integration. Using RNA-seq and wholeexome sequencing data from 366 patients across melanoma, renal cell, urothelial, and gastric cancers, BDVAE learns low-dimensional latent …
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Hormetic dietary phytochemicals from Western Canadian plants: Identification, characterization and mechanistic insights
Activation of mammalian stress responsive pathways by plant secondary metabolites may contribute to the protection against certain chronic diseases afforded by fruit and vegetable consumption. This work focuses on the identification of plant compounds that activate the stress-responsive enzyme …
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Cages and Guests: Mechanistic Insights on Confinement Effects in Small Molecule Activation
Contains fulltext : 326875.pdf (Publisher’s version ) (Open Access)
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Mechanistic insights into the direct synthesis of H2O2 on transition metal catalysts
H2O2 is less environmentally impactful than many industrial oxidants such as Cl2. The auto-oxidation of anthraquinones is the current standard for industrial H2O2 production, however, this process requires significant energy input due to the extensive purification and concentration processes …
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