Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Mechanisms of toxicity"”.
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Mechanisms of toxicity in cell models of FSHD
Current consensus places the mis-expression of DUX4 in skeletal muscle as the cause for facioscapulohumeral muscular dystrophy (FSHD). Whereas DUX4 expression normally occurs during early embryonic development, ectopic DUX4 expression is highly toxic in human cells. In my thesis work, using a new …
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Mechanisms of toxicity and carcinogenicity of three alkylanilines
… have been associated with an increased risk of human bladder cancer, independent of cigarette smoking, in a published case-control study. Understanding the metabolic activation of and DNA adduct formation by these chemicals is an important first step in elucidating their mechanisms of …
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Elucidating mechanisms of toxicity and engineering Escherichia coli for tolerance of short chain fatty acids
… affects the environment. Therefore, a new method of synthesis for biorenewable and sustainable chemicals is needed. In this treatise, significant advancement in the production of short chain carboxylic acids during bacterial fermentation is described. This work offers new insights into carboxylic …
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Developing in vitro models to elucidate the mechanisms of toxicity of locked nucleic acid gapmer antisense oligonucleotides.
Antisense oligonucleotides are an emerging class of RNA therapeutics that have recently received several approvals from the clinic. Antisense oligonucleotides act at the RNA level to either degrade target RNA, or to regulate splicing of a particular gene, and have been applied to treat a variety of …
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Mitigating protein aggregation to reduce the toxicity inherent to Parkinson’s and Alzheimer’s diseases
Protein deposition in the form of amyloid fibrils is the hallmark of more than 40 human pathologies, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Misfolded protein oligomers formed as intermediates during the aggregation process have been strongly implicated in the onset and …
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Cardiovascular Outcomes Following Xenobiotic Pulmonary Exposures
Cardiovascular disease remains the leading cause of mortality in the developed world. Over the past decades, investigations have demonstrated that pulmonary exposure to xenobiotic particulate matter promotes and exacerbates cardiovascular disease including myocardial infarction. The impact of …
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In Silico Classification of Industrial Chemicals Associated with Acute Aquatic Toxic Action Utilising Molecular Initiating Events
Chemicals legislation requires the assessment of potential harm to humans and environmental species. There is a move away from testing industrial chemicals in animals to development and use of reliable non-testing methods towards Mode of Action (MOA) determination as an important part of …
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UNDERSTANDING CONDITIONAL MODES OF ACTIONS IN CHEMICAL-INDUCED TOXICITY USING RULE MODELS
… shifting efforts toward alternative methods for toxicity assessment is essential. However, slow regulatory acceptance of new approaches is governed by knowledge gaps in toxicity modes of action. In this thesis, I describe these challenges and the use of in vitro screening as an alternative of …
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Insights into Mechanisms of Amyloid Toxicity: Molecular Dynamics Simulations of the Amyloid andbeta-peptide (Aandbeta) and Islet Amyloid Polypeptide (IAPP)
Aggregation of proteins into amyloid deposits is a common feature among dozens of diseases. Two such diseases that feature amyloid deposits are Alzheimer's disease (AD) and type 2 diabetes (T2D). AD toxicity has been associated with the aggregation and accumulation of the amyloid β-peptide (Aβ); Aβ …
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Short- and Long-Term Effects of Commercially Available Gold Nanoparticles in Rodents
… potential use in biomedical applications. Nanotoxicity studies are urgently needed to validate their safety in clinical practice. The objective of this research was to assess the acute, subacute, and chronic effects of a single intravenous exposure to commercially available GNPs in two in vivo …
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The significance of OATP and CYP450 in statin-flavonoid interactions
… statins can have adverse events such as myotoxicity which can further progress to a potentially fatal condition, rhabdomyolysis. This risk is exacerbated by drug-drug interactions between statins and conventional medicines that may inhibit metabolic pathways important to statin clearance. …
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Mechanisms of monohalogenated acetic acid induced genomic DNA damage
Disinfection of drinking water stands among the greatest public health achievements in human history. Killing or inactivation of pathogenic microbes by chemical oxidants such as chlorine, chloramine, or ozone have greatly reduced incidence of waterborne diseases. However, the disinfectant also …
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Proteomic approaches to environmental stress in mussel Mytilus edulis due to emerging classes of anthropogenic pollutants
… a need for more research on emerging categories of environmental chemicals such as nanomaterials, endocrine disruptors and pharmaceuticals. Proteomics offers options and advantages for early warning of alterations in environmental quality by detecting sub-lethal changes in sentinel species such …
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Nanoparticle toxicity and molecular mechanisms in fish: A case study with silver nanoparticles
… (NPs) are widely used in a myriad of commercial and industrial products making their entry to the environment a likely event. NPs have unique physical-chemical properties that result from their small size and high surface area to volume ratio, making them highly reactive and …
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Toxicity of mycotoxins to insects and underlying molecular and biochemical mechanisms
… other mammals. To minimize the harmful effects of mycotoxins on humans, strict regulations have been established worldwide. Economic losses due to mycotoxin contamination are enormous and estimated at millions of dollars annually in the United States alone Insects inevitably encounter mycotoxins …