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Showing 1 to 20 of 31 for “"Mechanisms of regulation"”.
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Mechanisms of Regulation of Tau Ires Mediated Translation
<p>The translation of most eukaryotic mRNAs occurs in a cap-dependent manner. However, a subset of mRNAs are capable of initiating translation in a cap-independent manner by utilizing sequences in their 5’ UTR called IRES. It was previously shown that the 5’ UTR of the tau mRNA contains an IRES. In …
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Characterising mechanisms of regulation of hypoxia-inducible factors.
… protein, HIF. HIF is a heterodimer consisting of one of three alpha subunits (HIF-1a, HIF-2a or HIF-3a) and a beta subunit called Amt. The activation of HIF by hypoxia is a multistep process involving increases in both protein stabilisation and transcriptional potency of the alpha subunits. …
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Mechanisms of regulation of islet function by nadph oxidase
… insulin secretion (GSIS) involves a series of metabolic and cationic events, leading to translocation of insulin-laden secretory granules from a distal site toward the plasma membrane for fusion and release of insulin into circulation. Vesicular transport and fusion events are tightly …
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Mechanisms of Regulation of Mitochondrial Dynamics by the Actin Cytoskeleton
… occur is not fully understood. We investigated mechanisms of regulation of mitochondrial dynamics by the actin cytoskeleton. First, we examined actin’s influence over equivalent mitochondrial partitioning between daughter cells in mitosis. Propagating in the space surrounding mitochondria is a …
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Mechanisms of regulation of the spindle position checkpoint kinase, Kin4
Most cells are polarized in that they are aware of spatial cues and can respond to these cues accordingly. One major aspect of cell function that is often responsive to these polarization cues is cell division. Cell division, the process of making two cells from one progenitor, requires equal …
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Mechanisms of Regulation of Proximal Tubule Sodium Transporters in Obesity-Induced Hypertension
<p>Hypertension is one of the common complications of obesity. Using a rat model of diet induced obesity and hypertension we investigated some of the mechanisms that are involved in regulation of blood pressure in obesity. The first aim of this study was to determine the role of proximal tubule …
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Mechanisms of Regulation and Resistance for Plasmid-Encoded ampC Beta-Lactamase Genes
BETA-lactam antibiotics are the largest class of antimicrobial drugs and the most frequently prescribed world wide. As the use of these agents increased so did the evolution of bacterial BETA-lactam resistance. BETA-lactamases are collectively the most commonly identified BETA-lactam resistance …
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Inhibition of AMPK via phosphorylation at Ser485/491: multiple mechanisms of regulation
… diminish lipid synthesis, and alter expression of various genes. AMPK activity is diminished in animals with the metabolic syndrome, though the mechanisms causing this reduction are unknown. To examine nutrient-induced changes in AMPK activity over time and factors that may regulate it, we …
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Mechanisms of regulation of sloppy-paired genes in the temporal patterning program of optic lobe medulla neuroblasts in drosophila
… published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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Signals Regulating Organelle Transport in Melanophores
To investigate the mechanisms of regulation of motor proteins driving melanosome transport, the phosphorylation states of the motors and the levels of motors on the organelles were examined. Immunoprecipitation of myosin V showed that the motor subunit is more heavily phosphorylated in cells …
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ΕΠΙ ΤΗΣ ΕΝΕΡΓΟΠΟΙΗΣΕΩΣ ΤΗΣ ΕΜΒΡΥΙΚΗΣ ΑΙΜΟΣΦΑΙΡΙΝΗΣ ΕΙΣ ΤΟΝ ΕΝΗΛΙΚΟΝ
… TO ADULT HEMOGLOBIN PRODUCTION, BUT TRACE AMOUNT OF FETAL GLOBIN EXPRESSION CAN BE DETECTED THROUGHOUT THE ADULT LIFE. KNOWLEDGE OF THE MECHANISMS OF REGULATION OF GLOBIN GENE EXPRESSION IS VERY INTERESTING BECAUSE OF THE ELACIDATION OF THE PHENOMENON AND THE PRACTICAL APPLICATION IN THE VARIOUS …
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Mechanistic and physiological insights into post-transcriptional regulation by small RNAs SgrS and DicF
… are important post-transcriptional regulators of gene expression in bacteria. These sRNAs deploy novel mechanisms to regulate mRNA targets leading to various physiological outcomes during stress conditions including, but not limited to, iron starvation, carbon flux and metabolism, virulence, …
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Characterization of Endothelial Nitric Oxide Synthase Serine-600 Phosphorylation
… nitric oxide synthase (eNOS) is part of a family of three nitric oxide synthase (NOS) enzymes that catalyze the production of nitric oxide (NO). NO is a gaseous, free-radical signaling molecule that has a variety of cellular and physiological functions that range from maintaining …
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Structural and functional analysis of a phospho-dependent molecular switch: Rv1827 from Mycobacterium tuberculosis
… precise roles in Ser/Thr kinase pathways and mechanisms of regulation remain unclear. From experiments with Rv1827, an FHA domain–containing protein from Mycobacterium tuberculosis, a complete molecular description of an FHA-mediated Ser/Thr protein kinase signalling process is derived. First, …
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Novel Regulatory Mechanisms of Cytoplasmic Dynein: A Role for the Complex Base
… its size and complexity but also its diversity of functions. It is essential for many mitotic and interphase transport processes and its misregulation or malfunction results in devastating neurological disorders. Over 20 years of research in the field has identified many recruitment and …
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Cloning and characterization of AdeMNO RND efflux pump of Acinetobacter baumannii
… pathogen which has been implicated in a variety of nosocomial infections among immunocompromised patients worldwide. Recently, Multi-drug resistant (MDR) isolates of A. baumannii have been isolated from military personnel returning from service in Iraq and Afghanistan. Antibiotic resistance of A. …
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A Compartive Analysis Of The Evolution Of Forest Management In The United States In General, With A Focus On Oregon, North Carolina
The purpose of this paper is to evaluate and discuss the evolution of forest management practices in the United States. The paper discusses the trends in forest management that have occurred within the United States in general, and specifically within the western (Oregon) and southern (North …
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Stochastic Modeling of Gene Expression and Post-transcriptional Regulation
Stochasticity is a ubiquitous feature of cellular processes such as gene expression that can give rise to phenotypic differences for genetically identical cells. Understanding how the underlying biochemical reactions give rise to variations in mRNA/protein levels is thus of fundamental importance …
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Temporal gene expression and regulation in T4 phage
… However, many questions regarding gene regulation in T4 phage remain unanswered. In this study, we employ end-enriched RNA-seq (Rend-seq) and ribosome profiling to examine T4 RNA and protein synthesis throughout the course of infection, gaining new insights at the transcriptional, …
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Calcium-dependent changes of apical membrane sodium channel density and open probability in frog skin
Blocker-induced noise analysis of Na$\sp{+}$ channels at apical membranes of intact and isolated epithelia of frog skin was carried out to investigate whether treatment of tissues with ionomycin, quinine, or acidification of basolateral solution shared similar mechanisms of inhibition of Na$\sp{+}$ …
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