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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Mechanism of resistance"”.
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Mechanism of Resistance in Common Ragweed to PPO-inhibiting Herbicides
… tools to help growers produce a healthy and profitable crop for several decades but their efficacy is under attack from the evolution of herbicide-resistant weeds. Almost all commercially available herbicidal modes of action have documented cases of herbicide-resistant weeds. One particular …
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Mechanism of resistance to tyrosine kinase inhibitors in philadelphia-positive acute lymphblastic leukaemia (all): from genetic alterations to impaired RNA editing
… led to significant improvements in the treatment of patients with Ph+ ALL, in the majority of cases resistance developed quickly and disease progressed. Some mechanisms of resistance have been widely described but the full knowledge of contributing factors, driving both the disease and resistance, …
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Characterization of the Mechanism of Resistance of a Johnsongrass (Sorghum halepense) Biotype to Selected Graminicides in Virginia and Response of Mugwort (Artemisia vulgaris) to Specific Herbicidal and Cultural Control Strategies
… rhizomatous perennial weeds that are capable of rapidly colonizing a variety of different environments. Separate experiments were conducted throughout Virginia from 1996 to 1999 to determine more effective methods for reducing infestations of these perennial weeds in the future. Field and …
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EGFR in Early Non-small Cell Lung Cancer: Tyrosine Kinase Inhibition in a Neoadjuvant Trial
… early disease, we implemented a phase II trial of neoadjuvant gefitinib in clinical stage I NSCLC. Tumour shrinkage was seen in 43% of patients, with 11% achieving RECIST partial response (PR). Analysis of molecular markers showed EGFR TKD mutations in 17% of cases, being the only associated …
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Adrenal steroid, blocking agent, and social stress effects on northern fowl mite population development on Leghorn chickens and toxicological evaluation of selected acaricides (Acarina: <i>macronyssidae</i>)
Administration of adrenal steroids or blocking agents at optimum doses influenced northern fowl mite development on chickens. Corticosterone at 20 ppm or desoxycorticosterone at 30 ppm in feed were most effective in inhibiting mite infestations. High levels of social stress increased resistance of …
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Mechanism of vector resistance in groundnut to control groundnut rosette virus disease in Sub-Saharan Africa
Analysis of biological performance parameters of Aphis craccivora on groundnut variety ICG12991 in laboratory and field trials demonstrated that ICG12991 was resistant to the aphid vector of groundnut rosette diseases and that this resistance was stable over time and under high aphid pressure. …
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Expression of the P-glycoprotein Homologue1 on food vacuoles isolated from Chloroquine-sensitive and resistant Plasmodium falciparum strains
Worldwide occurrence of chloroquine resistance is an expanding problem in prophylaxis and treatment of malaria. Similarities between the drug resistance phenotype in certain cancers and in malaria suggest that homologue multidrug resistance proteins might be involved in the mechanism of resistance. …
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Fungicide Resistance of Botrytis Cinerea from Virginia Wine grapes, Strawberry, and Ornamentals Crops
Botrytis cinerea is the principal member of the species complex that causes bunch rot of grapes and gray mold disease on other hosts including fruits and ornamental crops. It has developed resistance to many fungicides, and isolates from eastern US strawberry fields have regularly been identified …
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Characterisation of Small Ubiquitin-like Modifier (SUMO) protein complex expression in human cancer cells to identify novel therapeutic targets
… a post-translational modification where a number of small ubiquitin-like modifier proteins (SUMO) are conjugated to lysine residues of the target proteins and contribute to various cellular functions essential for cancer cell survival and proliferation. The unique behaviours, phenotypic and …
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Utilization of Proton Pump Inhibitors in Combination Regimen for Breast Cancer Treatment by Targeting Fatty Acid Synthase
… it has also been found that overexpression of FASN causes resistance to DNA-damaging treatments by up-regulating the non-homologous end joining (NHEJ) repair of DNA double-strand break. Proton pump inhibitors (PPIs), were originally designed to decrease gastric acid production by binding …
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The Role of Androgen Receptor Signalling in Endocrine Resistant Breast Cancer
… cancer among women in the UK. The majority of BCas are endocrine sensitive and develop through the action of oestrogens, facilitated through the transcription factor Oestrogen Receptor alpha (ERα). Treatment for these patients usually involves endocrine therapies (Aromatase Inhibitors and …
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STUDIES ON INSECTICIDE RESISTANCE IN TUTA ABSOLUTA (MEYRICK), WITH SPECIAL EMPHASIS ON CHARACTERISATION OF TWO TARGET SITE MECHANISMS
… (Lepidoptera: Gelechiidae) is a primary pest of tomato plants and is native to South America. Since the first documented European case in 2006, it has spread throughout the Mediterranean basin and North Africa. Larval stages cause direct feeding damage and reductions to both yield and fruit …
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The influence of non-inhibitory concentrations of purified pyocin S2 on Pseudomonas aeruginosa isolates
… using S-type pyocins to decrease the virulence of other isolates in a Drosophila melanogaster model. We have reason to believe that this decrease in virulence may not only be because of the direct inhibition of the target isolates but additionally from a reduction in their virulence factor …
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Non-target-site resistance to ALS inhibitors in waterhemp
… amino acid biosynthesis, and is the target site of five families of herbicides referred to as ALS inhibitors. Waterhemp (Amaranthus tuberculatus) is considered one of the most problematic weeds in the Midwest cropping region. The evolution of herbicide resistance and multiple resistance …
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Population genetics of herbicide resistance in waterhemp
… been identified throughout the Midwest and the mechanism of resistance in populations from Illinois was previously determined to result from a 3 base pair deletion in the protoporphyrinogen oxidase (PPO)-encoding gene, PPX2. The deletion results in the loss of glycine at position 210 (ΔG210). …
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Tracking soybean mosaic virus movement in soybean by leaf imprint immunoassay
The responses of soybean (Glycine max (L.) Merr.) to soybean mosaic virus (SMV) include mosaic, necrosis and no symptoms, and vary with virus strain and allele of the gene for resistance (Rsv) carried by the host. Genetic studies have shown that plants giving mosaic are susceptible, and that plants …
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Phenotypic and molecular antifungal susceptibility testing of yeast isolates from Pretoria
Antifungal drug resistance is a growing problem. Several mechanisms contribute to the development of resistance to antifungal agents. In South Africa, little is known about the antifungal susceptibility of local yeast isolates. The aim of this study was therefore to determine the antifungal …
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The location, expression and regulation of three antibiotic resistance genes in acinetobacter
Clinical isolates of Acinetobacter often exhibit resistance to many antibiotics, including the aminoglycosides and chloramphenicol. Yet very little is known about this resistance at the molecular level. A strain of Acinetobacter baumannii (strain SAK) was isolated from a tracheal aspirate; it is …
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Exploiting rice diversity to uncover durable and broad-spectrum resistance
… constraints towards a sustainable productivity of this cereal are losses caused by bacterial diseases, such as bacterial blight (BB) and bacterial leaf streak (BLS). Therefore, strategies aimed at increasing the global production of rice are essential. BB and BLS are caused by Xanthomonas oryzae …
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A Role For Lipid Rafts In Egfr Tki Resistance In Breast Cancer
… HER2+, and basal-type. With the introduction of targeted therapies against estrogen receptor and HER2 receptor mortality rates of American women with breast cancer have declined. Unfortunately, basal-type breast cancers, which have the worst clinical outcome, do not express estrogen receptor …
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