Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 702 for “"Mechanism of action"”.
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Mechanism of Action of Freund's Complete Adjuvant
… in DSpace on 2014-12-09T22:30:16Z (GMT). No. of bitstreams: 1 6812101.pdf: 3377124 bytes, checksum: 90fef7c60484d5295e5b690e9d48c96f (MD5) Previous issue date: 1968
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Quinolone mechanism of action: sensitivity, mutagenesis and tolerance
Antibiotics are a foundation of modern medicine, helping to save millions of lives since their discovery in 1928. But the improper and excessive use of these drugs over the last few decades has led to an alarming increase in antimicrobial resistance; coupled with the recent decrease in antibiotic …
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Studies on the Mechanism of Action of Calmodulin
The major goal of this research was to cast some light on the fundamental principles underlying the mechanism of action of calmodulin (CaM). This was approached through the study of the interactions of CaM with Ca('2+)+CaM sensitive cyclic nucleotide phosphodiesterase (PDE) and with troponin I. …
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Mechanism of Action of the Antifungal Antibiotic Pyrrolnitrin
… in DSpace on 2014-12-09T18:06:31Z (GMT). No. of bitstreams: 1 6910867.pdf: 4251027 bytes, checksum: a9373d3191b464067a8723e2725cbb91 (MD5) Previous issue date: 1968
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Biosynthesis and mechanism of action of enterococcal cytolysin
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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Development and Mechanism of Action of Antimicrobial Coatings
… coatings can inhibit the spread, via surfaces, of various diseases that infect humans. Antimicrobial coatings are useful because they can continue to kill pathogens (germs) for a long time after the surface is coated. This is a big improvement over use of common disinfectants that must be …
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QUANTITATIVE PROTEOMIC APPROACHES TO STUDY DRUG MECHANISM OF ACTION
In recent years an increased number of covalent protein kinase inhibitors has been approved for cancer therapy and many more are undertaking clinical trials. Covalent binding is usually obtained by introducing in these drugs an electrophilic warhead able to bind specific nucleophilic sites in the …
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Studies on the mechanism of action on antitumour imidazotetrazinones
… currently proving successful in the treatment of melanomas and gliomas. The exact nature of the biological processes underlying response are as yet unclear.This thesis attempts to identify the cellular targets important to the cytotoxicity of imidazotetrazinones, to elucidate the pathways by …
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Studies on the mechanism of action of thyroid hormones
Inosine monophosphate (IMP) is a precursor of the two purine nucleotides, adenosine monophosphate (AMP) and guanosine monophosphate (GMP)e through DEAE-Scphacex, and the reaction IMP~ XMP is catalyzed by: IMP dehydrogenase which was purified in a manner similar to adenylosuccinate synthetase. …
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Investigation of the mechanism of action of pep carboxylase
… developed in order to obtain large quantities of the highly-purified enzyme. Two assay systems were employed for studying phosphoenolpyruvate carboxylase. Since oxaloacetic acid, the phosphoenolpyruvate carboxylation product, is unstable under the reaction conditions, malate dehydrogenase and …
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Mechanism of action of a tumour derived lipid mobilising factor
… This is attenuated by co-incubation with 10μM of antagonist SR59230A and partially attenuated by 25μM PD098059 (indicating β3-AR and MAPK involvement respectively). LMF/ZAG induced in vitro lipid depletion in differentiated 3T3-L1 adipocytes that seen to comprise a significant increase in …
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Head-to-head terpene synthases: Mechanism of action and inhibition
… and carotenoid biosynthesis: the condensation of two isoprenoid diphosphates to form cyclopropylcarbinyl diphosphates, followed by ring opening. In this work, I used x-ray crystallography, and mutagenesis to study the catalytic mechanism of Staphylococcus aureus dehydrosqualene synthase. …
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ISPH fusion proteins, ISPH inhibition, and bisphosphonate mechanism of action
In the first part of this work, IspH, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate reductase was studied. In most bacteria, apicomplexan parasites, and plants, the biosynthesis of the five carbon building blocks for terpenes is carried out by IspH. It is an essential enzyme not found in humans …
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Studies on the mechanism of action of propionyl-CoA carboxylase
… carboxylase has been purified to a state of near nomogeniety, and some of its enzymatic properties relating to substrate binding and mechanism of action have been studied. The enzyme was not found to catalyze the incorporation of solvent tritium at the c-carbon of propionylâ CoA in the …
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Mechanism of Action of Antipsychotics, Haloperidol and Olanzapine in vitro
Schizophrenia affects 1-1.5% of people in the United States alone. Haloperidol (HP), a butyrophenone and a typical antipsychotic, has been used as an antipsychotic drug in human. Unfortunately, the therapeutic effects of HP also come with severe extrapyramidal side effects, resulting in movement …
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Mechanism of Action of Nicotinamide Phosphoribosyltransferase Mediated Signaling in Oxidative Stress
… 1 billion people that are affected by a form of neurodegenerative disease. The most common forms of neurodegenerative disease are Alzheimer’s disease and Parkinson’s disease, along with diseases that are attributed to damage of the retina and optic nerve, such as macular degeneration and …
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Mechanism of Action of ING4 as a Transcriptional Coactivator of p53
<p>ING4 belongs to a family of proteins that have been implicated in tumor suppression and has been linked to the activation of p53 target genes in a p53- dependent manner. However the mechanism by which it interacts with p53 to activate transcription from these genes is unclear. In this study I …
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