Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Mechanism of Toxicity"”.
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An investigation into the mechanism of toxicity of zinc oxide nanoparticles.
The wide scale use of ZnO nanoparticles (NPs) in the world consumer market has resulted in likelihood of exposure to human beings. The present study was aimed to assess the in vitro and in vivo interactions of ZnO NPs in the mammalian system and to elucidate the possible mechanism of their …
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The androgen receptor independent mechanism of toxicity of the novel anti-tumor agent 11[beta]-dichloro
Inspired by the toxicity mechanism of cisplatin in testicular cancer, a series of bi-functional genotoxicants has been designed that supplement their DNA damaging properties with the ability to interact with tumor specific proteins. One such compound, 11[beta] -dichloro links an aniline mustard …
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Biological Consequences of Polyglutamine Repeats in Drosophila Muscle
… tract in the affected protein. Accumulation of these mutant polyQ proteins leads to formation of insoluble protein aggregates that impair many vital cellular processes. This manifests in neurodegenerative symptoms like progressive loss of motor control, cognitive decline, and neuropsychosis. …
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The therapeutic importance of isoniazid metabolism in elderly patients
This is a study of the role of oxygen free radicals in isoniazid induced toxicity and its implications on the safety of isoniazid containing regimens in elderly patients. During isoniazid metabolism, toxic metabolites are produced which, together with isoniazid, may lead to toxicity by mechanism …
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Molecular Modeling of the Amyloid β-Peptide: Understanding the Mechanism of Alzheimer's Disease and the Potential for Therapeutic Intervention
Alzheimer's disease is the leading cause of senile dementia in the elderly, and as life expectancy increases across the globe, incidence of the disease is continually increasing. Current estimates place the number of cases at 25-30 million worldwide, with more than 5.4 million of these occurring in …
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The Influence of Water Quality Characteristics on Vanadium Toxicity to Model Aquatic Organisms
Vanadium (V) is a contaminant of emerging concern for the Alberta oil sands region that could present a risk for aquatic organisms. Petroleum coke (PC) has been experimentally used to treat oil sands process-affected water (OSPW) to reduce organic toxicants. However, PC contains up to 1,000 mg of V …
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Biochemical Thermodynamic Modelling of Cellular Bioenergetics: A Quantitative Systems Pharmacology Approach
… is widely accepted that pharmacological activity of certain classes of drugs (e.g. anticancer, antimalarial) is related to their ability to accept one or two electrons. However, pharmacological activity via redox cycling is an understated mechanism of toxicity associated with many classes of …
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Investigation of Huntingtin’s Role in DNA Repair and Transcription
… disease, caused by the expansion of a CAG repeat tract in the mutant Huntingtin gene (mHTT). The mechanism of toxicity imparted by mHTT has yet to be fully elucidated, despite decades of research since its description. Research into the normal cellular function of wild type HTT has …
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The Expression of Copper Transporters in Rat Dorsal Root Ganglion Neurons and its role in Oxaliplatin Neurotoxicity
… anticancer agent used for the treatment of colorectal cancer. Oxaliplatin chemotherapy is associated with peripheral neuropathy and dorsal root ganglia neurons are the putative target, however the mechanism of toxicity is currently unknown. Recent evidence suggests that copper …
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Toxicity of manufactured nano-ZnO to Lemna minor
The rapid development of nanotechnology has led to a rise in the large-scale production and commercial use of engineered nano-ZnO. Engineered/manufactured nano-ZnO are applied in a broad range of products such as drugs, paints, cosmetics, abrasive agents and insulators. This can result in the …
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Small bowel obstruction and toxicity of a new model of adhesion prevention
… is a common surgical diagnosis. If no signs of strangulation are evident, the majority of the patients can be conservatively managed. Approximately one third of the patients need surgical treatment and there is a need for early parameters that can predict operative intervention. The etiology …
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Bacterial Responses to Silver Nanoparticle Treatment: Community Structure, Resistance, and Function.
<p>The antimicrobial properties of silver have been taken advantage of by societies for thousands of years. Its use has come back in favor in the form of silver nanoparticles, which are highly efficacious antimicrobial agents. Silver nanoparticles are incorporated into a myriad of products …