Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"Mechanical strain"”.
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Evaluating the Electrical Response of Polyaniline to Mechanical Strain
… of polyaniline films subjected to uniaxial strain in hydrochloric acid solutions. Polyaniline belongs to novel class of materials known as conducting polymers. Alternating single and double bonds in the backbone of conducting polymers allow them to transmit electric charge when they are …
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Distributed optical-fibre sensors for monitoring mechanical strain and disturbance
This thesis reports work carried out to develop an optical sensor capable of detecting disturbance of optical fibre cables, for application in protection of telecommunications infrastructure. Initially, three types of sensor were investigated, however after preliminary experimental and theoretical …
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Investigation of the effects of Mechanical Strain in Human Tenocytes
… aims to investigate the effect of cyclic tensile strain loading and TGFβ stimulation on protease and ECM protein expression by human tenocytes and begin to characterise the pathway of mechanotransduction. Human tenocytes were seeded at 1.5x106 cells/ml into collagen gels (rat tail type I, 1mg/ml) …
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Regulation of vascular smooth muscle cell function by mechanical strain
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1996.
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Mechanical Strain-Mediated Syndecan Regulation and Its Effects on Adhesion of Vascular Smooth Muscle Cells
… gene expression was observed experimentally by mechanical strain of SMCs. Using real-time polymerase chain reaction (PCR), the kinetics of both static and cyclic mechanical strain were found to modify the gene expression in a time and strain magnitude-dependent manner unique to each syndecan. In …
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Hole transport in strained SiGe-channel MOSFETs : velocity in scaled devices and mobility under applied mechanical strain
… scaling of CMOS has been supplemented with strain to boost transistor drive current. Future CMOS technology nodes (i.e. beyond the 32 nm node) will require more significant changes to continue improvements in transistor performance. Novel CMOS channel materials and device architectures are …
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Investigating Mechanical Strain-Induced Phenotypic Changes on Prostate Cancer Cell Toward Metastasis Using a Three-Dimensional <i>In-Vitro</i> Model
… tumor cells are exposed to a myriad of altered mechanical forces that could dramatically modify their behavior. The objective of this thesis is to utilize a three-dimensional (3D) <i>in-vitro</i> model to investigate mechanical strain-induced phenotypic changes in prostate cancer (PC3) cells, …
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Biomechanical regulation of cancer metastasis
… recreate the cell-cell interactions and mechanical forces that occur during cancer cell adhesion and exit from the vasculature at the secondary site. Here we study cancer cell adhesion in the presence of physiologic shear stress and the effects of mechanical strain on cancer progression …
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Biochemical and mechanical cues tune fibronectin conformation and function
… regulators, such as heparan sulfates, and mechanical strain. However, the relative influence of allosteric regulators and mechanical forces on fibronectin conformation has not been determined. This conformational regulation is especially important in the context of the heparin 2 binding …
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An investigation into thermomechanical fatigue of metal matrix composites
… approaches are used to characterize the thermomechanical deformation behavior of metal matrix composites. Experiments on unreinforced and SiC particulate reinforced Al 2xxx-T4 have been conducted under several mechanical strain-temperature phasing conditions. Based on stress range, substantial …
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Investigation of a role for the α7 integrin as a mechanotransducer of hypertrophic signaling in skeletal muscle
… of hypertrophic signaling in response to mechanical strain. METHODS: Primary myoblasts extracted from wild type (WT) mice were developed into myotubes in culture to determine the hypertrophic signaling response to mechanical strain. Primary myoblasts from α7 knockout (KO) mice were used as …
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Neurons under tension: A study of vesicle dynamics
… Growing experimental evidence suggests that mechanical tension plays a significant role in determining the growth, guidance, and function of neurons. Recent developments in experimental techniques have made quantitative studies at the level of individual cells possible. The purpose of this …
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The role of heparan sulfate proteoglycans and heparanase in the control of vascular remodeling
… vascular remodeling in response to altered mechanical environments such as hypertension and injury. We first studied the effect of in-vitro mechanical strain on the ability of endothelial cells to inhibit vascular smooth muscle cell proliferation. Under these conditions we found mechanical …
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The Strain Gradient Effect on Material Behavior at the Micron and Submicron Scales
… micromirror device (DMD) and find that the strain gradient effect significantly increases the mechanical strain energy in the DMD and reduces the rotation time of the micromirror.
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Stretch Injury Alters Calcium Dynamics and Actin Organization in Human Astrocytes
… stem cell (hiPSC)- derived astrocytes respond to mechanical strain, aiming to reproduce changes in astrocyte behavior that can initiate neurodegeneration. In this research, a two- dimensional in vitro stretch model was used to apply controlled mechanical strain to monolayers of hiPSC-derived …
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Scleraxis-mediated regulation of tendon and ligament cell mechanobiology
… this, reinjury is common. It is well known that mechanical stimulation is beneficial for promoting tendon and ligament development and tissue homeostasis; however, the specific mechanisms remain unclear. The transcription factor scleraxis (Scx) is an interesting candidate for mediating the tendon …
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Design and manufacturing of PDMS micro structures with dynamic inclination angle
… micro and nanoscale texture due to in-plane mechanical strain. The studied textured surfaces have vertical 1D nanostructures, such as carbon nanotubes, integrated on flexible carrier films with inclined angle-tunable microstructures. An example of hierarchical geometry is proposed and …
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Concentric-core optical fiber sensors
This thesis describes the implementation of a mechanical strain sensor which uses concentric core optical fiber waveguide as the sensing element. When this particular type of fiber is strained, a transfer of optical power occurs between propagating modes in the two concentric cylindrical cores of …
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The role of autophagy in protecting periodontium integrity, and lipopolysaccharide-induced osteoclast differentiation
… that autophagy can be activated by both mechanical stretching and inflammation, however the mechanisms involved are highly context dependent. Autophagy may also be important for bone remodeling in the oral cavity. Two scenarios where bone remodeling is key to the physiological outcome are …
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