Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Measurable residual disease"”.
-
Clinical Impact of A Highly Sensitive Next-Generation Sequencing Measurable Residual Disease Assay In Patients With Acute Lymphoblastic Leukemia
<p>Measurable residual disease (MRD) is highly prognostic for relapse and overall survival (OS) in acute lymphoblastic leukemia (ALL), although many patients with apparent “MRD negativity” by standard assays still relapse. We evaluated the clinical impact of a highly sensitive next-generation …
-
Combining mechanistic modelling with data-driven modelling in mathematical oncology
… relapse problem. We investigate the dynamics of residual disease in individual patients to mathematically model leukemia evolution in observed response and relapse kinetics. We developed stochastic and deterministic, patient-specific models that can integrate longitudinal measurable residual …
-
A Novel NGS Assay to Detect Any KMT2A Fusion Transcript at Low Levels
<p>Measurable residual disease (MRD) detection is associated with cancer relapse. Leukemias with rearrangement of the lysine methyltransferase 2 A gene (<em>KMT2Ar</em>) have an adverse prognosis with more than 80 possible fusion partner genes (FPG) identified. With the advent of effective targeted …
-
Computational Frameworks to Interpret Genetic Abnormalities in Hematologic Malignancies
… I describe computational methods to detect residual leukemia cells remaining post-treatment (termed "measurable residual disease" (MRD)). I show that NGS-based MRD detection is feasible in different subtypes of AML at various time points. In addition, estimating sequencing error rates helps …