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Showing 1 to 11 of 11 for “"Measles virus"”.
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The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
… to early neuronal damage or stress. Many diverse viruses are capable of invading the neonatal CNS including Borna Disease Virus, Coxsackievirus (CV), Herpes simplex viruses (HSV), and measles virus. Although, we understand that many viruses can cause CNS disease, the mechanisms of viral …
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Monitoring immune dynamics following infection and vaccination using B cell receptor sequencing
… to the study of natural infection with measles virus in unvaccinated children. Childhood measles causes a profound immune suppression, which can last for weeks to months post infection, with large reductions in numbers of circulating B cells. Interestingly, long-term consequences of …
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Evaluating measles vaccination coverage in high incidence areas of the Western Cape Province, following the mass vaccination campaign
Measles virus is known to be one of the most contagious of infectious agents and despite considerable progress towards elimination, a number of Sub-Saharan African countries experienced epidemics in 2009-2011, including South Africa, in which there were over 18 000 confirmed cases. The South …
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The pathogenesis of classical Hodgkin lymphoma : investigation of possible viral pathogens and recurrent chromosomal imbalances
… of young adults with cHL are non-Epstein-Barr virus associated and epidemiological studies have suggested that a common infectious agent may play a key role in the aetiology of these cases. The molecular biology of HL is not well understood, primarily due to the low number of Hodgkin and …
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Regulation of the Human Parainfluenza Virus (hPIV3) Fusion Protein
<p>Paramyxoviruses include a number of important human pathogens, including measles virus, mumps virus, and the human parainfluenza viruses (hPIV) 1-4, as well as several animal pathogens, such as Sendai virus, Nipah virus and Hendra virus. The creation of effective drugs and vaccines against this …
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Subacute measles encephalitis: The neurological sequelae of the measles outbreak in South Africa
A measles outbreak occurred in South Africa between 2009 and 2011 with 18 699 confirmed cases. This highly contagious virus can affect the central nervous system in many ways. Early in the disease course there may be direct viral involvement as a primary measles encephalitis or indirectly as an …
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Impact of anti-viral immunity on neural stem/progenitor cell activity and implications for CNS development
… infections. They may be directly infected by the virus or respond to inflammatory cytokines released from resident as well as infiltrating immune cells. This bystander effect may affect NSPC differentiation and proliferation depending on the milieu of inflammatory mediators. Interferon gamma …
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Untersuchung der Masernvirus-induzierten Immunsuppression im Baumwollrattenmodell
Die Infektion mit MV Wildtypvirus führt zu einer starken Immunsuppression und Sekundärinfektionen, die bei der Immunisierung mit einem attenuierten Vakzinestamm nicht auftreten. In vitro Studien zeigen, dass sowohl MV Wildtyp- als auch Impfstamminfizierte Zellen die Mitogen-induzierte Proliferation …
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Untersuchung der Infizierbarkeit von Endothelzellen mit Masernviren und des Interferon-induzierten antiviral wirksamen Mechanismus
Das Masernvirus (MV) gehört zu den negativ-strängigen RNA-Viren der Familie der Paramyxoviridae und verursacht beim Menschen akute und subakute Enzephalitiden. Es wurde beschrieben, dass sich MV-RNA in den Endothelzellen von SSPE (subakute sklerosierende Panenzephalitis)-Gehirnen nachweisen lässt …
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Interaktion von Masernviren mit humanen Dendritischen Zellen
Das Masernvirus ist ein Mitglied der Familie der Paramyxoviridae. Obwohl eine wirksame attenuierte Lebendvakzine erhältlich ist, bleiben Masern eine bedeutende virale Infektionserkrankung, die jährlich ca. eine Millionen Opfer fordert. Trotz einer während der Infektion induzierten protektiven und …
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Die Rolle definierter Subpopulationen humaner peripherer Blutzellen für die Masernvirus-induzierte Immunsuppression und Immunaktivierung
Eine Masernvirus- (MV) Infektion induziert eine effiziente virus-spezifische Immunantwort. Aber parallel erfolgt eine generelle Suppression immunologischer Funktionen, die sekundäre Infektionen ermöglichen und verstärken kann. Eine Lymphopenie und die ex vivo beobachtete stark verminderte …