Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Mdm4"”.
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In Vivo Significance of The Mdm4 and P73 Interaction During Development and Tumorigenesis
… protein p53 is negatively regulated by Mdm4 protein. The significance of such regulation was determined from mouse models. Mdm4-deficient mice are embryonic lethal at E7.5 in a <em>p53</em>-dependent manner. p73, a member of the p53-family, is a transcription factor with tumor suppressor …
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Context Dependent Roles of MDMX (MDM4) and MDM2 in Breast Cancer Proliferation and Circulating Tumor Cells
<p>Many human breast cancers overexpress the E3 ubiquitin ligase MDM2 and its homolog MDMX. Expression of MDM2 and MDMX occurs in both estrogen receptor α positive (ER+) and triple negative breast cancer (TNBC). We and others have reported that estrogen activated MDM2 strongly promotes …
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Étude d’un mécanisme d’induction de la sénescence par les défauts de la machinerie d’épissage
… l’épissage. L’épissage alternatif de l’exon 6 de MDM4, générant le variant MDM4-S, s’est avéré être le plus réactif aux traitements. Finalement, une répression des variants de MDM4 ainsi qu’un sauvetage de la forme courte MDM4-S, ont démontré l'importance de l’épissage de MDM4 dans l’induction de …
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p53 Functional Interactions: the Study of a New Crosstalk with Estradiol Pathway in Transcriptional Responses to Chemotherapeutics
… p53 with positive and negative cofactors (e.g. MDM4 and 53BP1) and the impact of small molecules, including chemotherapeutic drugs, on such interactions. Previous reports have revealed a complex, often negative, crosstalk between p53 and estrogen receptors (ERs) related in part to the physical …
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Genomic Characterization of Recurrent Chromosomal Aberrations in Retinoblastoma
… the augmented copy number status of KIF14 and MDM4 on 1q and of DEK and E2F3 on 6p. A small subset of retinoblastoma exhibits high-level amplification of the MYCN gene on chromosome 2p and is characterized by pRb expression and aggressive histology. 1p36 deletion is also associated with MYCN …
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Is melanoma associated leucoderma (MAL) a distinct entity compared to classial vitiligo?
… on p53 regulation, including p21, p76MDM2, MDM4/MDM4phospho, SPARC, VEGF-A and TGF-β1. In part II, we wanted to characterize MAL and compare this peculiar leucoderma with classical vitiligo using the same protein panel and methodologies. To achieve our goals, we used in vivo FT-Raman …
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PRMT5 Inhibitors in Merkel Cell Carcinoma
… alternative splicing of the p53-regulator MDM4, suggesting a possible mechanism for the drug’s greater efficacy in p53-wildtype cell lines.