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Showing 1 to 2 of 2 for “"Mdm2 overexpression"”.
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Role of MDM2 In Cell Growth Regulation
MDM2 has been shown to induce G0-Gl/S phase arrest. To determine the cell cycle step targeted by MDM2, flow cytometry was employed to detect induction of events during the G1-S phase transition in MDM2-arrested cells. MDM2 overexpression does not prevent expression of cyclin D, cyclin D-CDK …
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Therapeutic Efficacy of P53 Restoration In Mdm2-Overexpressing Tumors
… Other mechanisms, <em>e.g.</em> upregulation of Mdm2 levels, exist in tumors to inactivate the p53 pathway. Mdm2, an E3 ubiquitin-ligase that targets p53 for proteasomal degradation, is present at high levels in many tumors with wild-type p53. In this study, we probed the effects of restoring p53 …