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Showing 1 to 3 of 3 for “"Mcm10"”.
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Mechanism of Mcm10 function during DNA replication
… proceed, however, until an additional protein, Mcm10, associates with the CMG. Mcm10 continues to travel with the replication fork after stimulating initial DNA unwinding but a function for Mcm10 during DNA replication elongation had not been established. Using a combination of molecular …
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Mcm10 regulates the turnover of DNA polymerase alpha.
… multiple functions at the fork. Critical for Mcm10's role at the fork is its DNA binding activity. Utilizing the crystal structure of the conserved internal domain of X. laevis (x) Mcm10, we identified residues that, when mutated, significantly reduced xMcm10's ability to bind DNA in vitro. …
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Characterization of the Role of Mcm10 in DNA Replication in Drosophila melanogaster
… factors called mini-chromosome maintenance 10 (Mcm10) as an essential DNA replication factor. First discovered in S. cerevisiae, Mcm10 is an abundant nuclear protein that has been implicated in the activation of the Pre-RC, interacts with members of the elongation machinery such as Pol[alpha], …