Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Mc4r"”.
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Transcriptional Regulation of Melanocortin 4 Receptor by Nescient Helix-Loop-Helix-2 and its Implications in Peripheral Energy Homeostasis
Mutations in the melanocortin 4 receptor (MC4R) are the most frequent cause of monogenetic forms of human obesity. Despite its importance, the MC4R signaling pathways and transcriptional regulation that underly the melanocortin pathway are far from being fully understood. The transcription factor …
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From genomics to function: Canine genetics highlight novel mechanisms of obesity and related traits
… in obesity. Missense variants MC3R p.M320I and MC4R p.V213F were detected at varying frequencies across the breed groups. The loss-of-function mutation, MC3R p.M320I, was common in Labrador retrievers. Carrying the mutation was associated with delayed onset of puberty and a decrease in adiposity …
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Novel Bifunctional Ligands For Neuropathic Pain: Design and Synthesis of Overlapping Pharmacophores of Opioid and Melanocortin Ligands
… In recent years, the melanocortin-4 receptor (MC4R) found in the spinal cord and CNS has received growing attention as a therapeutic target. MC4R based agonist ligands produce anti-opioid effects, and researchers have shown that an antagonist of the MC4R can produce pronounced anti-allodynic …
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Individual genetic variations of eight SNPs associated with risk of obesity in preschool age children from STRONG Kids Program
… pathway (i.e. BDNF, FTO, LEP, LEPR, MC4R, PCSK1, POMC, TUB) have been associated with symptoms of poor appetite control and obesity-related phenotypes. Hypothesis. Individual genetic variations related to satiety and appetite control in the BDNF, FTO, LEP, LEPR, MC4R, PCSK1, POMC, and …
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MECHANISMS OF RAPID RESOLUTION OF DIABETES FOLLOWING ILEAL INTERPOSITION SURGERY IN THE RAT
… for the central melanocortin 4 receptor (MC4R) would exhibit metabolic benefits from ileal interposition surgery. MC4R deficient rats are extremely obese and insulin resistant. Ileal interposition improved glucose tolerance in MC4R deficient rats, even when obese knockout rats were …
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Identifizierung und molekulare Analyse Xmrk-gekoppelter Gene in der geschlechtsbestimmenden Region des Genoms von Xiphophorus maculatus
… Duplikation eines Melanocortin-Rezeptorgens mc4r nachgewiesen werden, von dem 9 Kopien auf dem X-Chromosom in einer Tandem-ähnlichen Struktur vorliegen und mindestens 9 Kopien auf dem Y-Chromosom. Mindestens 11 der insgesamt 19 Kopien besitzen nicht unterbrochene offene Leseraster, deren …
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The Mechanism of Obesity in Rai1+/- Mice
… leptin levels and the expression of Pomc, Mc4r, Bdnf, and Agrp. Treatment with ampakine drug may increase expression of Bdnf and help to control obesity in Rai1+/- mice.
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Transcriptional and Post-transcriptional Control of Nhlh2 with Differing Energy Status
… many other transcription factors including MC4R and PC1/3 which are associated with human obesity. The Nhlh2 promoter has been analyzed for putative transcription factors binding sites. These putative binding sites have been tested to be the regulators of Nhlh2 by transactivation assays with …
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Untersuchungen zu Mutationen in Kandidatengenen für die Adipositas in einem Kollektiv von Patienten mit massivem Übergewicht
1) Der Melanocortin - Rezeptor Typ 4 (im Hypothalamus) ist Bestandteil des Regulationskreislaufes der Nahrungsaufnahme. Ein Kollektiv von Patienten mit extremer Adipositas wurde auf Mutationen im Gen des Rezeptors hin untersucht. Neben bekannten Polymorphismen fand sich eine bisher noch nicht …
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The Impact of Melanocortin Receptor Ligands on Astrocyte Signalling and Metabolism
… and metabolic activities. While MC3R and MC4R were initially considered the main MCR subtypes expressed in CNS neurons, recent evidence suggests that other MCR subtypes may also be present, although their expression and function in astrocytes remain poorly defined. This thesis addresses …
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Mapping the Feeding Circuitry in the Mouse and Human Brain
… neurons, and neurons expressing the MC3R and MC4R. Using the mouse and human hypothalamic atlases, we identify and characterise GLP-1R expressing populations, describing similarities and differences between the mouse and human. We confirm co-expression of *GLP1R* with key transcripts of …
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MOLECULAR PATHWAYS ANALYSIS THROUGH MULTI-OMICS APPROACHES TO STUDY THE BIOLOGICAL BASIS OF ANOREXIA NERVOSA
… candidate genes such as NNAT, EPHX2, LEP, and MC4R offering the potential to tailor treatments, predict disease progression, and assess recurrence risk within families. Moreover, genetic testing is crucial for distinguishing between true AN and syndromic forms that mimic AN but have distinct …
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Understanding the Aetiology of Metabolic Diseases and Related Phenotypes through Human Genetics
… in the UKBB. At the gene-level, I confirmed that MC4R, POMC, and PCSK1 exhibit haploinsufficiency effects on adult BMI using gene burden tests of rare variants with predicted LoF effects. From a clinical genetics perspective, this study underscored the utility of biobank datasets in informing the …
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A retrospective study exploring clinical, biological and behavioural factors contributing to changes in body weight following early breast cancer diagnosis.
… from medical notes. Genetic profile (FTO, Mc4R), body fat and fat free mass, waist circumference and fasting glucose and insulin levels were measured once, at study entry only. Associations were examined using t-tests, correlations, regression and multilevel modelling. Results: Participants …
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Mechanisms of hypothalamic regulation of food intake in birds
… while it increased proopiomelanocortin (POMC), MC4R, CRF, and CRFR2 in quail. These results suggested that the anorexigenic effect of CRF may involve a dampened neuropeptide Y (NPY) system in chicks whereas it is associated with activated CRF and melanocortin systems in quail. At the nucleus …
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A systems biology approach to the pathogenesis and progression of Non-Alcoholic Fatty Liver Disease
… some genetic models of obesity (ob/ob, MC4r) augment liver damage induced by these diets, making them valuable tools to achieve more advanced disease stages and/or faster models. 2. Identification of the molecular landscape of NAFLD progression. All previous work describing NAFLD …
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Neural Mechanisms of Homeostatic Need and Reward
… in mice after an ablation of POMC neurons or in MC4R knockout mice. In contrast, a POMC-specific deletion of Tsc1, which leads to a cell specific increase of mTOR activity, resulted in leptin resistance in chow-fed animals and reduced leptin sensitivity in these and ob/ob mice. In …