Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Mature neurons"”.
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Axonal transport and life cycle of mitochondria in Parkinson's disease model
<p>In neurons, normal distribution and selective removal of mitochondria are essential for preserving compartmentalized cellular function. Parkin, an E3 ubiquitin ligase associated with familial Parkinson’s disease, has been implicated in mitochondrial dynamics and removal. However, it is not clear …
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Integration and function of new neurons generated from fibroblasts and adult neural stem cells in the pathological brain
… the function and integration of “new” neurons – new neurons born from neural stem cells in the adult brain, and new neurons in the sense that they were generated from fibroblasts. Papers One and Two focused on the new neurons generated from neural stem cells in the SVZ and SGZ after …
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Lis1 and Ndel1 Regulate Dynein-Mediated Organelle Transport In Adult Neurons
… regulates key events in mitosis and migration of neurons during embryonic brain development (1). Lis1 and its binding partner, Ndel1, both bind to the motor protein cytoplasmic dynein (2). This microtubule-based motor is best known for its role in retrograde axonal transport (3), but also clearly …
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CELLULAR ALTERATIONS OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE FGF14−/− MOUSE MODEL
… neurogenesis (the production of functionally mature neurons from progenitor cells in the adult mammalian brain) is linked to the etiology of many neurodegenerative and psychiatric disorders. Studies have shown that neurogenesis is clearly a multifactorial and complex process that includes …
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Roles of HDACs and MEF2 in Adult Hippocampal Neurogenesis
… dentate gyrus. HDAC5 is only expressed in immature and mature neurons. Using Hdac5 knockout mice and in vitro cell culture, I show that HDAC5 is necessary and sufficient to restrict the neuronal differentiation of NSPCs. However, the detailed mechanisms are yet to be determined. Class IIa …
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Direct generation of region-specific induced neural Precursors from adult human fibroblasts using non-viral and viral methods
… to neural precursor cells, and subsequently mature neurons and glia, by the introduction of the defined neural transcriptional factors SOX2 and PAX6. However, the understanding of the underlying gene changes that occur during reprogramming was limited, as gene characterisation in direct …
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Promoting Central Nervous System Regeneration by Targeting Intracellular Pathways
Adult central nervous system neurons regenerate poorly after injury. One reason for this regenerative failure is that a developmental change occurs where essential growth-molecules become excluded from axons with maturation. In this thesis, two strategies were employed in order to improve axon …
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Die Verteilung des cellular retinoic acid binding protein-I (CRABP-I) und der Retinoidrezeptoren im optischen Tektum während der Entwicklung des Haushuhns Gallus gallus
… development. It was found in differentiating neurons of the generative zone, in migrating cells of the prospective stratum griseum et fibrosum superficiale and in mature neurons in this layer. in addition, I detected retinoid receptors in the developing tectum. These results are consistent …
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Development of P7C3-Class of Neuroprotective Molecules
… showed that the P7C3-series of compounds protect mature neurons outside of the hippocampus from otherwise overwhelming toxic insult, and that this protection is associated with preservation of normal neurological function. In these efforts, I also discovered a new function of the P7C3-series of …
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Investigating protrudin’s role in neuroprotection and axon regeneration in the central nervous system
… morphology, and protein localisation in neurons, and found varied but specific effects on different cellular systems. In particular, protrudin does not have any effect on the transport of late endosomes in CNS neurons — despite evidence for this mechanism in other cell types — due to the …
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The Role of SOX2 in Molecular Circadian Clock Regulation and Suprachiasmatic Nucleus Development
… cells terminally differentiate into neurons, SOX2 protein is usually eliminated and its gene transcription turned off, thus rendering it functionally irrelevant in most mature neurons. However, a hand full of brain regions contain fully differentiated neurons that are spared from Sox2 …
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Spontaneous and evoked vesicle cycling at a presynaptic terminal
… label pre-synaptic vesicles in living neurons. It consists of a fusion protein between VAMP2 and a biotin acceptor peptide (BAP). Co-transfection of biosyn with BirA, an enzyme that specifically recognizes the BAP sequence, results in the biotinylation of VAMP2. The subsequent addition …
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Alkyladenine DNA glycosylase (Aag)-dependent cell-specific responses to alkylating agents
… myeloid progenitors and cerebellar granule neurons (CGNs) where Aag' cells are resistant to MMS induced killing compared to WT. In this study, we investigated how Aag can cause cell-specific responses to alkylating agents. We generated new WT, Aag-/-, and Aag overexpressing (mAagTg) 129 and …
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Characterizing the Activity of Three Novel Differentiation-Inducing Compounds in Neuroblastoma Cells
… precursor cells that fail to differentiate into mature neurons. The biggest threat for high-risk neuroblastoma patients is treatment-resistant relapse due to minimal residual disease. Current post-remission maintenance therapy includes the use of differentiation agent 13-cis-retinoic acid. …
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The neural cell adhesion molecule 2 (NCAM2) promotes excitatory synapse formation through increasing insulin and insulin-like growth factor 1 receptor signaling
… This thesis demonstrates that in hippocampal neurons, NCAM2 is co-expressed with the insulin and IGF1 receptors during the peak period of synaptogenesis. NCAM2 colocalizes with the active insulin and IGF1 receptors in developing and mature neurons. In NCAM2-deficient neurons and astrocytes, …
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Bioinformatic Approaches to Study Mitochondrial DNA Heteroplasmy
… dendritic abnormalities, predominantly affecting mature neurons and resulting in cellular developmental delays. Additionally, I address the main challenges of working with single-cell multiome data, with a focus on mitochondrial genomics. A key objective in the field is to estimate hetero plasmy …
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The Epigenetic Role of EGR1 during Postnatal Mammalian Brain Development
… brains consist of millions to billions of neurons and glial cells that can be subdivided into many distinct types of cells. We hypothesize that brain methylomes are heterogeneously methylated across different types of cells and the transcription factors play key roles in brain methylome …
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Human neural stem cells: region-specific properties and prospects for cell therapy
… occlusion of the middle cerebral artery, mainly neurons in the cortex and striatum die. Therefore, we wanted to generate NSCs lines derived from the human fetal cortex and striatum and explore whether they maintain an intrinsic cellular identity in culture, consistent with their region of origin. …
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Analysis of an epigenetic regulator in mouse embryonic stem cell self-renewal and differentiation
… of trx2 mutant cells generated fewer mature neurons than wild type cells. Moreover a temporal delay in the developmental progression to differentiation became apparent. Cardiac differentiation of trx2-/- cells confirmed the developmental defect and temporal delay. Notably …
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Transcriptional profiling of Drosophila larval ventral nervous system hemilineages
Over 90% of neurons in the adult CNS of Drosophila are born from neuronal stem cells (neuroblasts) during the post-embryonic phase of neurogenesis. Most of the post-embryonic neurons derive from type I neuroblasts, which undergo repeated asymmetric divisions to produce a series of ganglion mother …
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