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Showing 1 to 8 of 8 for “"Matrix-Metalloprotease"”.
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Asthma: Cytokine-Induced Over-Expression of Matrix Metalloproteases Compromises Airway Epithelium Tight Junctions and a Clinical Case Study
… activity that up regulates expression of matrix metalloprotease 9. MMP9 encourages detachment-induced cell death - anoikis - which results in a structural change compromising the airway epithelium's ability to act as a primary immune defense mechanism. The chronic characterization of …
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Auswirkungen der maternalen HIV-1-Infektion auf die Genexpression endothelialer Vorläuferzellen und differenzierter Endothelzellen nicht-infizierter Kinder
… HIV-1-infizierter Mütter die Expression von Matrix-Metalloprotease-1 (MMP-1) unter der Nachweisgrenze liegt oder signifikant reduziert ist. Dies konnte auf RNA- und Proteinebene sowie mittels Gelatine-Zymografie bestätigt werden.
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Aggrecan fragments as biomarkers in osteoarthritis
… In osteoarthritis (OA) the balance of cartilage matrix synthesis and degradation is disturbed, resulting in a gradual destruction of the articular cartilage. Matrix components released into body fluids by proteolytic cleavage can be used as biomarkers of ongoing processes. This thesis focuses on …
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Identification of seminal proteins related to fertility of bulls
… metalloproteinase-2 (TIMP-2). TIMP-2 regulates matrix metalloprotease activity and therefore, potentially plays a key role in the structural makeup of the extracellular matrix. These findings suggest that regulation of enzymatic activity in seminal fluid is in large part a function of heparin …
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Charakterisierung zweier im Mammakarzinom überexprimierter Gene: LIV-1 und Stromelysin-3
… ungeeignet zu sein. Für die sekretierte Matrix-Metalloprotease SL-3, deren prognostische Signifikanz bereits bekannt war, wurde gezeigt, dass eine Überexpression in humanen Brusttumorzelllinien deren Zellzahl in 3D Zellkulturmodellen erhöht. Dieser Effekt war abhängig von der IGF-1 …
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Adamts9 is critical for the development of primary ovarian follicles
Adamts9 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 9) is an extracellular matrix metalloprotease that is highly evolutionarily conserved and critical for development in vertebrates. Knockouts of ADAMTS9 in mice and AdamTS-A in Drosophila melanogaster are embryonic …
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Die Expression von Matrix-Metalloproteasen in humanen Medulloblastomen
… in welchem Masse Medulloblastome verschiedene Matrix-Metalloproteasen exprimieren. Diese Enzyme spielen bei der Gewebeumstrukturierung und Neoangiogenese im Rahmen der Tumorinvasivität eine wesentliche Rolle. Über das Verteilungsmuster bei Medulloblastomen ist im Vergleich zu anderen …
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Chemical biology of matrix metalloproteases
Matrix Metalloproteases (MMP) inhibition is currently brought to the focus of medicinal chemistry research due to their essential roles in many human diseases. To elucidate the functions of each individual MMP, it is imperative to synthesise small molecule/probes which can selectively target a …