Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 91 for “"Matrix proteins"”.
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Fibronectin and Laminin, extracellular matrix proteins, have an origin in mesoderm tissue and promote anterior neural tube closure in zebrafish
… In all vertebrates, there is an extracellular matrix between the mesoderm and the developing neural tube. I hypothesized Fibronectin (Fn) and Laminin (Lam), extracellular matrix proteins, have an origin in mesoderm tissue and promote anterior neural tube closure. Supporting my hypothesis, the …
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Isolation and characterization of a common nuclear matrix protein and other studies
The nuclear matrix, the RNA-protein skeleton of the nucleus, is known to play functional and structural roles within the cell. My thesis investigated the roles of the nuclear matrix proteins under various circumstances. First, the rat prostate cancer cell line (MLL) was injected into various sites …
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The Use of Dynamic Fluid Flow Strategies for Bone Tissue Engineering Applications
… to stimulate the synthesis of an extracellular matrix rich in osteogenic and angiogenic factors that are envisioned to guide bone healing in vivo. Fluid flow, which exerts a hydrodynamic shear stress on adherent cells, has been identified as one of the strongest stimuli on bone cell behavior. It …
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Growth Factor and Extracellular Matrix Regulation of Heifer Mammary Development
… locally derived growth factors and extracellular matrix proteins in regulating prepubertal heifer mammary development. In the first experiment, short-term treatment of heifers with GH or E increased proliferation of mammary epithelial cells. Coinciding with increased epithelial cell proliferation, …
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Chondrocyte gene expression and intracellular signaling pathways in cartilage mechanotransduction
… the composition of the cartilage extracellular matrix. This study utilized three loading protocols that span the range of forces and flows induced by in vivo loading. Constant (static) compression of cartilage explants induces a transient hydrostatic pressure buildup and fluid exudation from the …
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Aging Effects on Arterial Mechanics and Matrix Remodeling
… structure composed of cells and extracellular matrix proteins. Passive arterial mechanical behavior is determined by the composition of extracellular matrix proteins, in particular elastin and collagen. Elastin provides reversible elasticity to the large elastic arteries during cyclic loading …
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Decellularized Normal and Cancer Susceptible Mice Colons to Study the Contribution of the Extracellular Matrix to Cell Behavior and Colon Cancer Progression
… cancer lack architectural support and signaling proteins provided by the tissue extracellular matrix (ECM) which may influence cell behavior and cancer progression. Therefore, the ability to study cancer cells in the context of a matrix that is physiologically more relevant and to understand how …
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The regulation of matrix metalloproteinase (MMP) secretion in human vascular cells exposed to extracellular and wound matrices
… in wounds during healing. The regulation of matrix metalloproteinases (a key superfamily of proteases involved in the above process) by wound healing components is an area of ongoing investigation. However, a systematic study of the exposure of the human derived vascular cells - endothelial …
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Immune Responses Aginst Aldehyde Modified Extracellular Matrix in Atherosclerosis
… of MDA that modified surrounding extracellular matrix (ECM) proteins. These modifications may subsequently target immune responses against the plaque ECM and influence the atherosclerotic process. Our studies provide evidence for the presence of MDA-modifications on ECM proteins during …
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Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts
Stromal cells and the extracellular matrix (ECM) components provide the microenvironment that is pivotal for cell growth, motility, attachment and differentiation. Fibroblasts are some of the cells responsible for the synthesis of most of the extracellular matrix proteins. Type I collagen is the …
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Molecular and Functional Analysis of Otolith Formation in Zebrafish, Danio Rerio
… otoliths. Although there are more than two-dozen proteins in otoliths, only few of them are identified and known to be involved in otolith formation. Therefore, the goal of Chapter 2 is to identify unknown otolith genes by proteomics and investigate their roles in otolith formation. As a result, …
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The interaction of angiocidin and tissue transglutaminase
… between the cell and the extracellular matrix (ECM). Cell adhesion molecules are found on the surface of all cells and play a role in cell-cell and cell-extracellular matrix interactions. Tissue transglutaminase is ubiquitously expressed in various tissue types, occurs in both an …
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The structural and functional changes of blood vessels during aging
… a robust expression of endothelin system proteins in the adventitia. Additionally, extracellular matrix proteins collagen and fibronectin, and the proliferation marker Ki67 showed strong adventitial origin. The changes observed in the vascular adventitia with aging clearly demonstrate an …
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Characterization of Human Airway Epithelial to Mesenchymal Transition upon Rhinovirus Infection
… of AR that is due to increased deposition of matrix proteins by mesenchymal cells that are increased in asthmatic airways, although the origin(s) of these cells are unclear. We have shown that two different strains of HRV, alone and in the presence of transforming growth factor-β1, caused …
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… role in cancer cell migration and invasion. The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules, and to perform key functions in tumor progression, and …
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The heterogeneous biochemical modification of porous collagen scaffolds for tissue engineering applications
The extracellular matrix is a complex and dynamic collection of collagens, non-collagenous matrix proteins, glycosaminoglycans and growth factors. The ECM plays a significant role in guiding the behavior of cells in their tissue specific niche. The recapitulation of both the mechanical and …
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Clinical Applications of Stem Cells in Ocular Surface Reconstruction.
… to determine the distribution of extracellular matrix proteins in processed amniotic membrane (AM) carriers. Various components of the culture system (including carrier, media and cell type) were evaluated in a number of separate studies. The results of this thesis show that denuded amniotic …
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Fibronectin splice isoforms in wound healing and vascular development
Fibronectins are a large family of extracellular matrix proteins that regulate cell adhesion, migration, differentiation and survival. Different isoforms of fibronectin arise via alternative splicing of the transcript of a single gene. Although many of the general functions of fibronectins have …
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Coaxial Electrospinning of Synthetic/Natural Polymer Combinations for Controlled Release of Active Components in Biomedical Applications
… emphasis on incorporating extracellular matrix proteins and biologically active components. By systematically investigating process parameters, this study elucidates the structural and functional properties of coaxial fibres and their implications for biological response. Extensive …
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Developing platforms to investigate mechanotransduction during wound healing
… with limited functionality. The extracellular matrix regulates forces on a cell- and tissue-specific level. Fibronectin, a mechanically regulated extracellular matrix protein that binds integrins, growth factors, and other matrix proteins, is an irreplaceable modulator of wound healing. Despite …
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