Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"Matrix metalloproteinases (MMPs)"”.
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Visualizing the Spatial Localization of Active Matrix Metalloproteinases (MMPs) using MALDI Imaging MS
… including cytokines, chemokines, and matrix metalloproteinases (MMPs). The nature of the FBR requires the spatial and temporal regulation of these mediators. MMPs are an extremely large and diverse group of enzymes that play key roles in regulating the FBR. Precise spatiotemporal …
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Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinases (MMPs) as biomarkers of bladder cancer development and progression
… It positively modulates the activity of the matrix metalloproteinases-9 (MMP-9) that are involved in the enzymatic remodelling of the extracellular matrix. MMP-9 regulates the degradation of extracellular matrix in processes such as angiogenesis, tumour growth, and metastasis. By forming the …
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The redox regulation of alpha 5 beta 1 integrin stimulated MMP production in articular chondrocytes
… of the articular cartilage extracellular matrix (ECM). ROS have been shown to serve as secondary messengers in integrin and cytokine signaling pathways which stimulate chondrocyte production of ECM-degrading enzymes called matrix metalloproteinases (MMPs). Fibronectin fragment (FN-f) …
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… role in cancer cell migration and invasion. The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules, and to perform key functions in tumor progression, and …
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Lipoteichoic acid from Staphylococcus aureus induced expression of MMP-9 in human middle ear epithelial cells
Change in matrix metalloproteinases (MMPs) and regulation of their tissue inhibitors of metalloproteinases (TIMPs) could play certain role in the pathogenesis of otitis media. This study was designed to evaluate the modulation of MMPs and TIMPs in middle ear epithelium by lipoteichoic acid (LTA) …
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Production of Extracellular Matrix-Degrading Proteases by a Rat B Cell Line.CRL-1631
Badeaux, K. Production of Extracellular Matrix-Degrading Proteases by a Rat B Cell Line.CRL-1631. Master of Science (Microbiology and Immunology), May 2002. 30 pp., 9 illustrations, 1 table, 16 bibliography titles. Previously B lymphocytes have been reported to accumulate at the site of tumor …
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Role of matrix metalloproteinases in regulation of late embryonic healing process
… Pivotal role in the wound healing is given to matrix metalloproteinases (MMPs). These remodelling enzymes are important for releasing cytokines, inducing apoptosis, and degradation of extracellular matrix. Our laboratory performed temporal RNA-sequencing of the healing tissue using tailbud …
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Transcriptional Regulation of Matrix MetalloProteinase-3 in Rat Brain Astrocytes.
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade extracellular matix (ECM) components during normal and pathogenic condition. Documented expression of MMPs contributes to tissue remodeling, atherosclerosis, and inflammatory diseases. MMPs are tight regulated by …
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Epithelial Tubular Fusion, Measuring Interconnection, and the Quest for Solving the Continuity Problem
… Additional studies with inhibitors of matrix metalloproteinases (MMPs) revealed a significant role for extracellular matrix turnover in lumen coalescence. These results lay the groundwork for investigating how to promote functional interconnections between tubular epithelia, which has …
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Preclinical Evaluation of Matrix Metalloproteinase Inhibitors and Protein Kinase C Activators in Cell and Mouse Models of Huntington’s Disease
… by proteases, including caspases, calpains and matrix metalloproteinases (MMPs). Previous research has also shown altered kinase signaling pathways in HD contribute to the localization of mutant huntingtin to the nucleus and to disruption of transcriptional regulation. Currently, there are no …
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The role of kisspeptin and its cognate receptor GPR54 in normal and abnormal placentation
… of factors such as oxygen tension, activation of matrix metalloproteinases (MMPs), angiogenic factors (VEGF-A) and immunological factors such as TNF alpha, interleukins and TGFβ have been shown to be involved in the control of trophoblast invasion. Our knowledge of the molecular details of …
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Of mice and men: can MMP-9 be a biomarker and a potential target for treatment after traumatic brain injury?
… for TBI that do not have severe side effects. Matrix metalloproteinases (MMPs) represent the most prominent family of endopeptidases that are necessary for normal growth and development but are also involved in the disruption of the blood-brain barrier (BBB), neuronal cell death, …
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Signaling and Adhesive Mechanisms in Acute Pancreatitis
… TLR4, lymphocyte function antigen-1 (LFA-1), matrix metalloproteinases (MMPs) and Rho-kinase as well as nuclear factor of activated T-cell (NFAT) signaling in AP. We found that TLR4 but not TLR2 plays a role in AP. LFA-1 adhesive mechanisms play a role in tissue damage and leukocyte …
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The role of MMP10 in non-small cell Lung cancer, and pharmacological evaluation of its potential as a target for therapeutic intervention. Investigation of the role of MMP10 in the tumour microenvironment of non-small cell lung cancer using gene, protein and mass spectrometry approaches to determine MMP10’s potential in drug development strategies
… chemotherapeutics are required. Among the matrix metalloproteinases (MMPs) that are essential for tumour development, MMP10 is a potential candidate as a therapeutic target based on its expression and contribution to NSCLC development. This research aims to explore the expression and …
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Characterization of proteins and tissue remodeling components in porcine aqueous humor
… involve the up-regulation of tissue remodeling matrix metalloproteinases (MMPs). The effects of age and gender on MMP and protein activity in porcine aqueous humor were determined in this study to identify correlations existing between MMP activity and glaucoma risk factors. Gelatin zymography …
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Crosstalk between colorectal cancer cells and tumour-associated macrophages
… environment. Remodelling of extracellular matrix (ECM) occurs in CRC. CD47 binding to α2β1 integrin could regulate cyclooxygenase-2 expression and cell migration on collagen I surface in intestinal epithelial cells. CD47 is involved in crosstalk between colon cancer cells and macrophages by …
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Pharmacological investigations into matrix metalloproteinase-activated anti-tumour prodrugs. In vitro metabolic and pharmacological investigations into a series of colchicine-based peptide prodrugs activated by tumour-expressed matrix metalloproteinases
Matrix metalloproteinases (MMPs) play a significant role in degrading the extra- cellular matrix in cancer development and metastasis. Overexpression of matrix metalloproteinases in tumour tissues relative to normal tissues has been exploited as a target for peptide-based therapeutics, to improve …
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HCMV Promotes Breast Cancer Metastasis: Impacts of CMVIL-10 in the Tumor Microenvironment
… are more likely to metastasize. In addition, matrix metalloproteinases (MMPs) degrade the extracellular matrix, which promotes cancer cell dissemination by permitting tumor cells access to the vascular and lymphatic systems. We found that MCF-7 human breast cancer cells express the cellular …
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Tissue inhibitor of metalloproteinase-1 contributes to ovulatory dysfunction in a rat model of endometriosis
… which mimics reduced fecundity in endometriosis. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are involved in endometriosis, but both are crucial for ovulation. Endometriotic lesions produce TIMP1, upsetting the balance of MMPs and TIMPs which can affect the ovaries and other …
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Characterisation and modulation of the gelatinase system of human Bruch's membrane
… Bruch’s has led to the hypothesis of diminished matrix degradation mediated normally by a family of protease enzymes called the matrix metalloproteinases (MMPs). Underlying mechanisms leading to diminished MMP activity in ageing Bruch’s remain unknown but functional changes of diminished …
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