NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 32 for “"Matrix metalloproteinase(MMP)"”.

  1. The regulation of matrix metalloproteinase (MMP) secretion in human vascular cells exposed to extracellular and wound matrices

    Bracher, MonaDepartment of Medicine2002

    … in wounds during healing. The regulation of matrix metalloproteinases (a key superfamily of proteases involved in the above process) by wound healing components is an area of ongoing investigation. However, a systematic study of the exposure of the human derived vascular cells - endothelial …

    cape-town Repository record

  2. Effect of Methamphetamine on Gingival Fibroblast Production of Matrix Metalloproteinase (MMP)-2 and -9 and Tissue Inhibitor of Metalloproteinase (TIMP)-1 and -2 In Vitro

    Farooqi, Owais Ali2016

    … by rampant caries and periodontitis. Matrix metalloproteinases (MMPs) produced by gingival fibroblasts degrade the extracellular matrix (ECM) and play an important role in periodontitis and oral cancer metastasis. There is no information on effects of METH on fibroblast MMP production, …

    tenn-hsc Repository record

  3. BASIGIN-2 MEDIATED ACTIVATION OF ERK1/2 SIGNALING IN HUMAN GLIOBLASTOMA MULTIFORME CELLS

    Peterson, Erik R2017

    … it contributes to malignancy via stimulation of matrix metalloproteinase (MMP) expression in surrounding normal tissues, resulting in the degradation of the extracellular matrix (ECM) surrounding tumors, promoting remodeling of the tumor borders, stimulating growth. In work by Belton et al. …

    nmu Repository record

  4. The Overexpression of Basigin-3 in Glioblastoma

    Wightman, Samantha M2016

    … the disease. The protein Basigin-2 (aka EMMPRIN) induces the expression of matrix metalloproteinase (MMP) enzymes, and its expression level is positively correlated with GBM tumor grade. In 2011, Liao et al. reported that a splice variant of the basigin gene, called Basigin-3, may have an …

    nmu Repository record

  5. Met Inactivation by S-allylcysteine Suppresses Migration and Invasion of Nasopharyngeal Cancer Cells Induced by hepatocyte growth factor

    조, 오연2016

    … the restoration of E-cadherin, the reduction of matrix metalloproteinase (MMP) and Slug protein expression, and inhibition of the production of reactive oxygen species (ROS). Furthermore, evidence is emerging that shows that ROS induced by radiation could increase Met activation. Following on …

    ajou Repository record

  6. Functional and structural uncoupling of the angiogenic and enzymatic inhibitory activity of TIMPs : loop 6 of TIMP-2 is a novel inhibitor of angiogenesis

    Fernández, Cecilia A., 1969-Massachusetts Institute of Technology2004

    Tissue inhibitors of metalloproteinases (TIMPs) regulate tumor growth, progression and angiogenesis in a variety of experimental cancer models and in human malignancies. However, numerous studies have revealed important differences between TIMP family members in their ability to inhibit angiogenic …

    mit Repository record

  7. BIOSENSING OF MATRIX METALLOPROTEINASE ACTIVITY WITH CD-FREE QUANTUM DOTS

    Plumley, John

    … low toxicity, and the ability to detect active matrix metalloproteinase (MMP) in a biosensing system, designed to identify direct biomarkers for pathological conditions, which in turn would enable early disease diagnosis and better treatment development. In this work, highly luminescent …

    unm Repository record

  8. Mechanisms of Erythropoietin-induced Neuroprotection in: in-vivo and in-vitro Models of hypoxia Ischema

    Souvenir, Rhonda Andrea

    … in an upregulation of tissues inhibitor of matrix metalloproteinase (TIMP)-1 and inhibition of hypoxia inducible factor (HIF-1α) both of which subsequently decreased in matrix metalloproteinase (MMP)-9 and promoted neuroprotection. MMP-9 inhibition was associated with neuroprotection in …

    loma-linda Repository record

  9. Abdominal aortic aneurysms : identification by self-examination and analysis of variation in matrix metalloproteinases with peak wall stress

    Heng, Michael Sern TserUniversity of Hull2011

    … may provide an economic and practical solution. Matrix metalloproteinase (MMP) concentration is elevated and levels of their natural inhibitors - Tissue Inhibitors of Matrix Metalloproteinases (TIMPs) are reduced at sites of AAA rupture. Finite element analysis (FEA) of AAAs can define the area …

    hull Repository record

  10. Improving the delivery and efficacy of a cancer therapeutic via extracellular matrix modification

    Mok, WilsonMassachusetts Institute of Technology2008

    The extracellular matrix (ECM) has been shown to be a significant source of hindrance to the transport of macromolecules in solid tumors. This thesis shows that by limiting their interstitial transport, the tumor ECM can reduce the efficacy of cancer therapeutics. Furthermore, techniques for …

    mit Repository record

  11. Oxime Click-crosslinked Cryogels to Quantify and Target Tumour-associated Macrophage Invasion in Hodgkin Lymphoma

    Bahlmann, Laura Christine2022

    … therapeutics. We analyzed the HL extracellular matrix (ECM) in primary tumours and found a high abundance of hyaluronic acid, collagen, and fibronectin, which guided the design of our HL-tumour mimetic hydrogel: a cryogel comprised of gelatin, hyaluronan, and fibronectin-derived peptides …

    toronto-retro Repository record

  12. The Role of EGFR Signaling in Gonadotropin-Induced Steroidogenesis

    Carbajal, Liliana2010

    … ligand-dependent activation that requires Matrix Metalloproteinase (MMP)-mediated release of membrane-bound EGF receptor ligands. However, only intracellular signaling is required for LH-induced steroid production. Furthermore, the LH-EGFR pathway appears to be important only for early …

    utswmed Repository record

  13. TREM-2 Expression and Regulation in Inflammation and Ischaemia

    Bradley, JennaUniversity of East Anglia2014

    … TREM-2 was required for TGF-β1-induced matrix metalloproteinase (MMP)-1 expression, the most characterised MMP in wound healing, suggesting that TREM-2 may be required for the beneficial effects of TGF-β1 on wound healing by regulating MMP-1. An in vitro model of ischemia in stroke was …

    east-anglia Repository record

  14. The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier

    현, 수왕2015

    … of ZO-1, degradation of claudin-5, increase of matrix metalloproteinase (MMP)-3/9 mRNA levels, and translocation of Forkhead box O 3a (FoxO3a) into nucleus. The effects of antioxidant, trolox, and N-acetyl-cysteine (NAC) as well as siFoxO3a transfection also mimicked those effects of OE, Quer, …

    ajou Repository record

  15. Coronary Artery Outcome in Kawasaki Disease: The Role of Matrix Metalloproteinase-9 and Therapeutic Modulation of Its Activity

    Lau, Andrew Chun-Ben2009

    … increased enzymatic activity of the elastase, matrix metalloproteinase (MMP)-9. MMP-9 protein and activity levels were elevated in the heart post-disease induction. Expression and activity were specific for and localized to inflamed coronary arteries. The pro-inflammatory cytokine, tumour …

    toronto-retro Repository record

  16. In-vitro assessment of modified resin adhesive-tooth interfaces

    Almahdy, AhmedKing's College London2013

    … The modification included the incorporation of matrix metalloproteinase (MMP) inhibitors within the primers of these adhesives.<br/><br/>Materials and methods:<br/>Two MMP inhibitors (BB94 and GM6001) were added to three adhesive primers, Optibond FL “OB” (Kerr, USA), Prime&Bond NT “PB” …

    kings Repository record

  17. The Impact of a Scleral Lens on the Eye

    Walker, Maria K.University of Houston2021

    … to the untreated (control) eye. Results: (1) Matrix metalloproteinase (MMP)-9 and MMP-10 were significantly greater in the FR, reaching 62.7 and 25.8 ng/ml, respectively, after 8-hours SL wear. (2) MDF samples were positively correlated to levels of wax esters (r = +0.76, P = 0.01) and …

    houston Repository record

  18. A Mechanistic Evaluation of how Melatonin Enhances Alkaline Phosphatase Activity in Human Adult Mesenchymal Stem Cells

    Radio, Nicholas2018

    … epidermal growth factor receptor (EGFR), and matrix metalloproteinase (MMP) activation were evaluated as potential upstream inputs of the MAP-K activation. Subsequent co-incubation of melatonin with specific PKA, EGFR, and MMP inhibitors revealed that EGFR and possibly MMP but not PKA activate …

    duquesne Repository record

  19. Investigation on the Intracellular Sognal Transduction Mechanism of Human Dermal Fibroblasts of Photorejuvenation in Photodynamic Therapy

    장, 용현2011

    … of PDT compared to that in other treatments. Matrix metalloproteinase (MMP)-1 and MMP-3 mRNA by real-time PCR significantly increased in PDT group compared with control group showing a maximal increase 24 h following PDT. TGF-β mRNA increased in PDT group at 6, 12 h post-PDT. Collagen Iα1 mRNA …

    ajou Repository record

  20. Engineering antibodies for improved targeting of solid tumors

    Schmidt, Michael MMassachusetts Institute of Technology2010

    … In the last section, we develop a series of matrix metalloproteinase (MMP) activatable antibody fragments that bind their target antigen up to 300 times faster following cleavage by the tumor expressed protease MMP-2. We believe that MMP dependent binding should prevent targeting of antigen …

    mit Repository record

Page 1 of 2