Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 99 for “"Matrix Protein"”.
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Extracellular matrix protein receptors in Drosophila melanogaster
The extracellular matrix (ECM) is defined as the many different proteins and secreted substances between cells. The ECM plays a major role in the signaling pathways that stimulate cells to perform many varied functions, ranging from control of gene expression at the cellular level to …
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The Role of Enamel Matrix Protein Amelotin on Biomineralization
… Amelotin (AMTN) is a recently discovered protein that is primarily expressed during the maturation stage of enamel formation and is localized at the cell-mineral interface on the surface enamel layer. In vivo studies using transgenic mice suggest a direct regulatory function for AMTN in …
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Cartilage oligomeric matrix protein in der Pathogenese der Arthrosis deformans
… ist das Cartilage oligomeric matrix protein (COMP) hauptsächlich in der extrazellulären Matrix zu finden. Eine häufige Bindung an Knorpel konnte bereits nachgewiesen werten. Weiter ist COMP in Synovialflüssigkeiten und dem Bandhalteapparat nachweisbar. Es konnten bereits …
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Investigation of the Vesicular Stomatitis Virus Matrix Protein: Uncoating and Assembly
… transcription, replication, and assembly. The matrix protein (M) of VSV is a central component of the viral replication cycle. While being the smallest of the viral proteins it is multifunctional and is involved in uncoating, cytopathic effects (CPE), and assembly of the virus. M protein …
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Isolation and characterization of a common nuclear matrix protein and other studies
The nuclear matrix, the RNA-protein skeleton of the nucleus, is known to play functional and structural roles within the cell. My thesis investigated the roles of the nuclear matrix proteins under various circumstances. First, the rat prostate cancer cell line (MLL) was injected into various sites …
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Expression and role of the extracellular matrix protein tenascin in ovarian cancer
Tenascin (TN) is a large hexameric glycoprotein which is expressed transiently in the extracellular matrix at times of tissue development, proliferation and reorganisation. It is overexpressed in the stroma of several types of malignant tumours. The expression of TN in ovarian cancer has not …
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A Study of the Membrane Binding Properties of the Matrix Protein from Human Respiratory Syncytial Virus
This thesis describes the structure of the matrix (M) protein from human respiratory syncytial virus (RSV), and its interactions with model membranes composed of a range of lipids, which have been characterized using a variety of techniques. The M protein was expressed in E. coli with a histidine …
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Matrix protein of vesicular stomatitis virus interacts with host Rae1 in multiple complexes to inhibit host transcription
MATRIX PROTEIN OF VESICULAR STOMATITIS VIRUS INTERACTS WITH HOST RAE1 IN MULTIPLE COMPLEXES TO INHIBIT HOST TRANSCRIPTION
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Fundamental study of pulse electric field effects on hela cell cultured over extracellular matrix protein micro-patterned surface
… In addition, this study focused on the effect of protein coated surface, combined with the pulse parameter mentioned above, to look at its effect on HeLa cell when exposed to high voltage. Thus, will lead towards cell surface attachment factors interrogation plus the presence of electric field as …
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The roles of nuclear matrix protein 4 and high mobility group box 1 in mediating the osteoblast response to anabolic agents
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Chemical Tagging of Surface Composition Gradients With Polystyrene Nanospheres and the Extracellular Matrix Protein Fibronectin for the Study of Cellular Migration
… covalently bind polystyrene nanospheres and the protein fibronectin (FN) to thiol gradient surfaces. Fluorescently doped, carboxylic acid-modified nanospheres were reacted with gradients of an amine-terminated thiol. Surface nanosphere distribution was probed with fluorescence microscopy, from …
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Fluid Flow Forces Regulate Fibrous Extracellular Matrix Protein Expression and Deposition Via A Rhoa/Rho Kinase Dependent Pathway During Atrioventricular Valve Development
… play a significant role in regulating fibrous proteins expression and deposition, which are critical components for embryonic cardiac valve morphogenesis. </p> <p>In chapter 2, our study demonstrated drastic increase of fibrous extracelluar matrix (ECM) proteins mRNA expression during cardiac …
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Adipose-Derived Adult Stem Cells as Trophic Mediators of Tendon Regeneration
… stem cells and increasing extracellular matrix production by tendon fibroblasts (TFBL). The purpose of this study was to evaluate the ability of adipose-derived cells (ADC) culture expanded from the SVF to act as trophic mediators in vitro. We hypothesized that ADCs would produce growth …
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Mechanisms of Post-hemorrhagic Hydrocephalus after Germinal Matrix Hemorrhage
… inherently fragile vasculature of the germinal matrix is susceptible to rupture, possibly as a result of hemodynamic and cardiorespiratory instability associated with prematurity. Germinal matrix hemorrhage is a leading cause of morbidity and mortality in preterm and/or very low birthweight …
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Wisp1 Is An Overexpressed Driver of Glioblastoma
… We identified WISP1, a secreted extracellular matrix protein, to be an overexpressed driver in GBM. Overexpression of WISP1 was able to drive tumor growth in various <em>in vivo</em> models. Knockdown of WISP1 with shRNAs resulted in reduced colony formation <em>in vitro</em> and reduced tumor …
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Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts
Stromal cells and the extracellular matrix (ECM) components provide the microenvironment that is pivotal for cell growth, motility, attachment and differentiation. Fibroblasts are some of the cells responsible for the synthesis of most of the extracellular matrix proteins. Type I collagen is the …
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Engineered biomaterials as extracellular microenvironments for guiding cell programming and reprogramming
… can sense their properties such as stiffness, matrix protein, and geometry and respond to these cues in multiple ways including through mechanical forces exerted on the matrix by the cells. Cells incorporate these cues via signal propagation through integrins, and translate this information …
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