Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Matrix Metalloproteinase-2"”.
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Expression, activation, and regulation of matrix metalloproteinase 2 (MMP-2) in the bovine corpus luteum
<p>Matrix metalloproteinases (MMPs) have been postulated to be important for angiogenesis and for tissue remodeling events associated with corpus luteum (CL) development. The MMPs are mainly regulated at three levels, transcription, activation, and inhibition by endogenous tissue inhibitors of …
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The mechanism of action of the scorpion toxin, chlorotoxin, a bioinformatics approach
… and high resistance to current treatment. Matrix metalloproteinase 2 (MMP2) is upregulated in glioblastoma multiforme (GBM) and its high expression is directly correlated with invasion and metastasis of GBM cells. Annexin A2 is involved in angiogenesis, and it is overexpressed in GBM. MMP2 …
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Protective Effects of Yuzu and Its Component against Cardiovascular Disease
… α-smooth muscle actin expression, and matrix metalloproteinase-2 activity in a permanent LAD occlusion rat model. These results suggest that yuzu and hesperidin have anti-platelet activity, and that intake of yuzu, which contains various flavonoids such as hesperidin, may be beneficial …
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Effects of systemic flunixin meglumine, topical oxytetracycline, and topical prednisolone acetate on tear film proteinases innormal horses
… meglumine, on the activity of two proteinases, matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), in equine tear film. The study design consisted of twelve ophthalmically normal horses separated into three groups of four in a cross-over study design. Each group was …
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Reevaluating Chlorotoxin Targets: Insights Into Glioblastoma Cell Migration and Neuropilin-1 Binding
… the molecular targets of Ctx are unclear, with Matrix Metalloproteinase-2 (MMP-2) and Neuropilin-1 (NRP-1) being the most studied candidates. Previous studies have identified the C-terminal region of Ctx as critical for inhibiting GBM cell migration. To explore this further, we designed …
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The effect of synthetic cannabinoids on wound healing of chondrocytes monolayers and pseudo 3D cartilage tissue. Effect of different concentrations of synthetic cannabinoids WIN55, 212-2, URB602 and HU-308 with and without their antagonists on wound healing of chondrocyte monolayers and pseudo 3D cartilage tissue.
… the effect of WIN-2 on nitric oxide (NO) and matrix metalloproteinase-2 (MMP-2) expressed by wounded chondrocyte monolayers. Moreover, expression of collagen type-I, collagen type-II, fibronectin and S100 proteins were detected using immunofluorescence and verified quantitatively using ELISA …
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Characterization of the prostacyclinIP receptor system in the rat kidney: Implications for diabetic nephropathy
… was observed in cell lysates, and an increase in matrix metalloproteinase-2; CCP had no effect on thymidine or leucine incorporation. In response to 24 hr and 4 day HG, CCP- and iloprost (ILP)-cAMP was attenuated in MG: immortalized and primary cultures, respectively. CCP-CAMP was also diminished …
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Selenium Effects on the Trabecular Meshwork
… the role of selenium in extracellular matrix turnover, I examined alterations in protein secretion and intracellular signaling. MSeA treatment (5-10 uM) led to a significant decrease in the secretion of matrix metalloproteinase -2 and its inhibitor after 6-24 hours and to a …
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Expression of Epidermal Growth Factor Receptor in hypopharyngeal cancer and Effect of EGF in Progression of hypopharyngeal cancer
… were performed to examine the roles of matrix metalloproteinase-2(MMP-2) and MMP-9, as well as the relationship between EGF and MMPs in FaDu invasiveness. Results: The positive rates of EGFR expression in hypopharyngeal SCC were 63.2%. EGFR staining was significantly correlated with …
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In vitro Untersuchungen zur Wirkung von Saccharidmimetika auf verschiedene Schritte der Metastasierung von malignen Melanomzellen
… und -Migration sowie der Aktivierung von Matrix-Metalloproteinasen untersucht. Erste Versuche mit galactosylierten Cyclohexan-Derivaten haben gezeigt, daß sich die Adhäsion von B16F10-Mausmelanom-Zellen an Fibronectin in Anwesenheit von 40 mM …
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Design of functional polymeric materials for cancer-targeted drug delivery and cellular capture and isolation
… oxygen species (ROS) and overproduction of matrix metalloproteinase-2 (MMP-2) enzyme for the design and synthesis of stimuli-sensitive synthetic block copolymer polymeric micelles (BCPMs) by reversible addition-fragmentation chain transfer (RAFT) polymerization for targeted delivery of …