NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 22 for “"Matrix Metalloproteinase 9"”.

  1. The Expression of Matrix Metalloproteinase-9 and -2 in Olfactory Injury and Recovery

    Bakos, Stephen2015

    … of the olfactory bulb (OB) remain unknown. The matrix metalloproteinases (MMPs) are important components in many central nervous system (CNS) injury paradigms, yet remain unexplored in olfactory injury and recovery. To address the role of MMPs, the temporal expressions of MMP-9 and MMP-2 were …

    vcu Repository record

  2. CANNABINOID RECEPTOR 2 AGONIST REDUCES IMMUNE CELL MIGRATION IN NEUROINFLAMMATION VIA INHIBITION OF MATRIX METALLOPROTEINASE-9

    Adhikary, SabinaTemple University. Libraries2013

    … levels of the adhesion molecule VCAM-1 and matrix metalloproteinases MMP-2 and 9 at peak of EAE in treated mice. The decrease in VCAM-1 correlates with our previous observation of decreased leukocyte rolling and adhesion to brain microvasculature. However, the reduction in MMP-2/9 expression …

    temple Repository record

  3. Coronary Artery Outcome in Kawasaki Disease: The Role of Matrix Metalloproteinase-9 and Therapeutic Modulation of Its Activity

    Lau, Andrew Chun-Ben2009

    … increased enzymatic activity of the elastase, matrix metalloproteinase (MMP)-9. MMP-9 protein and activity levels were elevated in the heart post-disease induction. Expression and activity were specific for and localized to inflamed coronary arteries. The pro-inflammatory cytokine, tumour …

    toronto-retro Repository record

  4. Inflammation Promotes the Processing of Glial Cell-Line Derived Neurotrophic Factor by Matrix Metalloproteinase-9 in Intestinal Smooth Muscle Cells

    Cirella, Kirsten2016

    … protease inhibitors or inhibitors of metalloproteinases (MMP) showed that only inhibition of MMP-9 specifically blocked TNFα-induced axonal proliferation. The inhibition of MMP-9 in co-cultures also blocked the increase in 15 kDa GDNF expression, while the overall expression of GDNF …

    queens Repository record

  5. Identification of Transmembrane and Extracellular Host Proteases that Promote Human CoV Entry and Syncytium Formation

    Mulloy, RoryUniversité d'Ottawa / University of Ottawa2021

    … and entry assays, I provide evidence implicating matrix metalloproteinase-9 (MMP-9) as a fusion trigger for SARS-CoV-2 and HCoV-229E. Additionally, I show MMP-9 expression is upregulated during CoV infection, highlighting its potential relevance as a CoV triggering factor.

    ottawa-retro Repository record

  6. The Regulatory Role of Mixed Lineage Kinase 4 Beta in MAPK Signaling and Ovarian Cancer Cell Invasion

    Abi Saab, Widian F.University of Toledo2013

    … MLK3 activation. In addition, MLK4 blocks matrix metalloproteinase-9 gelatinase activity and invasion in SKOV3 ovarian cancer cells, both of which are cellular responses that require MLK3. Collectively, our data establish MLK4beta as a novel suppressor of MLK3 activation, MAPK signaling and …

    ohiolink Repository record

  7. MECHANISM OF TRANSCRIPTIONAL REPRESSION OF MMP-9 BY INTERFERON-β

    Mittelstadt, Megan Laurel

    <p>Matrix metalloproteinase-9 (MMP-9) is a 92 kDa zinc-dependant endopeptidase that degrades components of the extracellular matrix. Enhanced expression of MMP-9 has been implicated in many pathological conditions including cancer metastasis, multiple sclerosis, and atherosclerosis. Although it has …

    south-carolina Repository record

  8. Of mice and men: can MMP-9 be a biomarker and a potential target for treatment after traumatic brain injury?

    Tomlinson, Brittany N.University of Missouri--Columbia2013

    … for TBI that do not have severe side effects. Matrix metalloproteinases (MMPs) represent the most prominent family of endopeptidases that are necessary for normal growth and development but are also involved in the disruption of the blood-brain barrier (BBB), neuronal cell death, …

    missouri Repository record

  9. Modulation of neutrophil degranulation by hypoxia

    Hoenderdos, KimUniversity of Cambridge2015

    … (elastase, myeloperoxidase, lactoferrin and matrix metalloproteinase-9). In consequence, supernatants from hypoxic neutrophils induced substantially more damage to lung epithelial cell layers than supernatants from neutrophils cultured under normoxic conditions; this damage was protein- and …

    cambridge Repository record

  10. Effects of systemic flunixin meglumine, topical oxytetracycline, and topical prednisolone acetate on tear film proteinases innormal horses

    Rainbow, Marc E.Virginia Tech2004

    … meglumine, on the activity of two proteinases, matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), in equine tear film. The study design consisted of twelve ophthalmically normal horses separated into three groups of four in a cross-over study design. Each group was …

    vt Repository record

  11. Oxime Click-crosslinked Cryogels to Quantify and Target Tumour-associated Macrophage Invasion in Hodgkin Lymphoma

    Bahlmann, Laura Christine2022

    … therapeutics. We analyzed the HL extracellular matrix (ECM) in primary tumours and found a high abundance of hyaluronic acid, collagen, and fibronectin, which guided the design of our HL-tumour mimetic hydrogel: a cryogel comprised of gelatin, hyaluronan, and fibronectin-derived peptides …

    toronto-retro Repository record

  12. Caffeine Binding Non-Canonical Biased Adenosine A₂AR GPCR Modulates Neu1 Activation and Signaling in Breast Cancer Cells

    Li, Yunfan2026

    … axis involving neuromedin B receptor (NMBR), matrix metalloproteinase‑9 (MMP9), and neuraminidase‑1 (Neu1) to modulate cancer‑associated phenotypes in breast cancer cells. Using sialidase assays, we found that caffeine induced Neu1 enzymatic activity in both MDA‑MB‑231 (TNBC) and MCF‑7 …

    queens Repository record

  13. The role of genetic factors in breast cancer aetiology

    Hammond, Victoria NaomiUniversity of Southampton2010

    … of SNPs in the<br/>oestrogen receptor gene and matrix metalloproteinase-9 gene (MMP-9) with grade and presence<br/>of distant metastasis respectively.<br/><br/>The function of two promoter SNPs in MMP-9 were further investigated using luciferase reporter<br/>gene assays. The C allele of …

    soton Repository record

  14. ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION

    Thapaliya, Monica2022

    … induced rosacea-like erythema, generation of matrix metalloproteinase 9 (MMP9), chemokine, CXCL2, and the recruitment of MCs and inflammatory cells in control mice but these responses were substantially reduced in GRK2-deleted mice. IgE-mediated anaphylaxis and itch were also significantly …

    penn Repository record

  15. Role of Type 2 Cannabinoid Receptor (CB2) in Atherosclerosis.

    Netherland, Courtney Denise2011

    … with elevated levels of the extracellular matrix degrading enzyme, matrix metalloproteinase 9 (MMP9). These results demonstrate that although CB2 signaling does not affect atherosclerotic lesion size it does modulate lesional apoptosis, cellularity and ECM composition. Ldlr-/- and …

    etsu Repository record

  16. Thymoquinone is a Novel Ligand which Activates Neu4 Sialidase to Promote a Pro-Inflammatory Response

    Finlay, Trisha2009

    … guanine nucleotide Gαi subunit and matrix metalloproteinase 9 (MMP9) by using specific inhibitors. In addition, TQ was found to induce sialidase activity in Toll-like receptor-deficient HEK293 cells. These latter data suggested that TQ may be activating GPCR Gαi and MMP9 signaling …

    queens Repository record

  17. Cannabinoid Type 2 Receptors Promote Cadherin Switching While Suppressing Cell Migration: A Novel Investigation into Biased GPCR Signaling

    Aldbai, Rachil2025

    … in complex with neuraminidase 1 (Neu1) and matrix metalloproteinase 9 (MMP9). This crosstalk facilitated the glycosylated receptor activation and downstream gene regulation mediated by nuclear factor kappa B (NF-κB). Importantly, cannabinoid type 1 (CB1) receptors have been implicated in …

    queens Repository record

  18. Cervical Remodeling/ripening At Term And Preterm Delivery: The Same Mechanism Initiated By Different Mediators And Different Effector Cells

    Gonzalez Velez, Juan Miguel2014

    … A significant increase in collagen degradation, matrix metalloproteinase 9 (MMP-9) activity and tissue distensibility was observed in the cervix in both models. Mice deficient in complement receptor C5a did not show increased MMP-9 activity and cervical remodeling and did not deliver preterm in …

    wayne-thes Repository record

  19. Stress Conditioning and Heat Shock Protein Manipulation for Bone Tissue Engineering

    Chung, EunnaVirginia Tech2010

    … increased with the addition of GFs. However, matrix metalloproteinase-9 (MMP-9) secretion was inhibited by heating, with more significant declines associates with GF inclusion. Equibiaxial tension (5%, 0.2 Hz, 10 seconds tension/10 seconds rest, 6 days) with GFs enhanced proliferation than …

    vt Repository record

  20. A MECHANISM FOR CORTICAL BONE STEM CELL-DERIVED EXOSOMES’ THERAPEUTIC EFFECT ON POST-MYOCARDIAL INFARCTION REPERFUSION INJURY AND CARDIAC REMODELING

    Schena, GianaTemple University. Libraries2021

    … a reduction in fibroblast-associated genes matrix metalloproteinase 9 (MMP9) and Collagen 3A1 (Col3A1), as evidenced by qPCR analysis. Next, to examine if exosomes decrease fibrotic activation, adult rat ventricular fibroblasts (ARVFs) and adult human cardiac fibroblasts (NHCFs) were treated …

    temple Repository record

Page 1 of 2