Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Matrisome"”.
-
Establishment of a Novel Patient hiPSC-derived in vitro Blood-Brain Barrier Model of Collagen IV Small Vessel Disease
… about the cause and disease progression of SVD. Matrisome alteration leading to blood-brain barrier (BBB) dysfunction is thought to play a role. Sporadic cases are exacerbated by age and vascular risk factors, predominantly affecting the elderly. However, mutations in Collagen IV α1/α2 …
-
Alternatively spliced isoforms of Fibronectin, Tenascin-R and other potential players in early vasculogenesis
… From these data, we identified a set of matrisome proteins that had decreased abundance in EIIIA/B double-null yolk sacs but were relatively unchanged in single-null and heterozygous yolk sacs compared to wild type.
-
Tissue-Specific Matrix Control of Cell Cohesion and Migration Signaling Complexes
… and cancer metastasis applications. Database (Matrisome/FANTOM5) and two-dimensional and three-dimensional cell culture analysis identified collagen XVII and the heparan sulfate proteoglycan perlecan/HSPG2 as two key ECM components controlling cell cohesion and migration in salivary gland and …
-
Characterisation of the pro-regenerative extracellular matrix in the zebrafish spinal cord
… adapted to the study of the broader effects of matrisome gene knockouts or injuries on the spinal cord ECM in this highly-regenerative model species. The data presented here help to characterise the gap in SCI regenerative capacity between zebrafish and mammals. The results implicate not only …
-
Enhanced Proteomic Methods to Decipher How the Novel Protein SNED1 Modulates the Extracellular Matrix
… but the SNED1-dependent changes in the matrisome was not yet identified. Thus, I hypothesized that SNED1 modulates the ECM architecture by influencing the ECM composition. In this thesis, I focused on answering this biological question and on enhancing proteomic methods to do so, using …