Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Maternal-fetal interface"”.
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UNDERSTANDING PLACENTAL IMMUNITY: CYTOKINE CONTROL OF CONGENITAL VIRAL INFECTION
… consequences to viral infection. Following maternal infection, certain viruses can traverse the placental barrier, establish infection in the fetus, and cause adverse pregnancy outcomes or congenital disease. To combat this, the placenta has evolved potent defenses including the constitutive …
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Dissecting immune interactions in health and disease with multiomics and spatial technologies
… (CVID) and, (ii) a spatial multiomics map of the Maternal-Fetal Interface (MFI) in early pregnancy in humans. Chapter 2 outlines materials and methods used in this work, showcasing the workflow for each project. Chapter 3 details the multiomics atlas of Common Variable Immunodeficiency (CVID). …
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Physical Factors Regulating Human Trophoblast Invasion
Pre-eclampsia, fetal growth restriction and stillbirth are major pregnancy disorders throughout the world. The underlying pathogenesis of these diseases is defective placentation characterised by inadequate invasion of extravillous trophoblast (EVT) cells into the uterine decidua. This invasion is …
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TISSUE ARCHITECTURE AND INTERCELLULAR COMMUNICATION: MEDIATORS OF PROTECTIVE OR PATHOGENIC INTERFERON RESPONSES
The central nervous system and maternal-fetal interface are challenged with protecting from pathogeninsult while limiting immunopathology. Previous work has defined how anatomical structures and regulation of immune responses by resident immune cells contribute to this balance. However, the …
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Maternal and placental adaptations to hypoxia
… vascular remodeling, which induced maternal adaptive responses to protect the fetus. In this dissertation, we describe studies designed to evaluate cellular and molecular mechanisms underlying maternal adaptations to hypoxia during the establishment of the hemochorial placenta. …
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The role of Ras-related C3 botulinum toxin substrate 1 (RAC1)-dependent pathway in the regulation of uterine function during early pregnancy
… time, new blood vessels begin to form in the maternal decidua from pre-existing vasculature. This process termed angiogenesis is critical for the establishment of the placenta and the maintenance of pregnancy. Although it is clear that decidualization and angiogenesis play a crucial role …
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Pareto Task Inference Analysis of Single-Cell RNASequencing of Human Placenta Reveals Biological Insightsinto Adverse Pregnancy Outcomes
… pregnancy outcomes (APOs), such as preeclampsia, fetal growth restriction, and preterm birth, occur in 10-15% of pregnancies. There is limited knowledge of how the cellular states in the placenta and decidua tissues are altered in women with particular APOs or may contribute to APOs. Single-cell …
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Molecular definition of group 1 innate lymphoid cells in the uterus
… blood vessels, an event necessary to support fetal growth. Recently, other ILCs were identified in the mucosa and wall of the uterus of mice and women, pregnant or not. They may regulate important functions as they produce factors known to impact on uterine physiology and pathology. Unique to …
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Multigenerational effects of abnormal folate metabolism on embryo growth and development
It has been known for decades that maternal folate deficiency impairs fetal development. However, the molecular mechanism of folate metabolism remains unclear. To explore this, we study a mouse model of abnormal folate metabolism whereby the gene Mtrr was mutated causing a knockdown effect. MTRR is …
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Investigating the immune modulatory properties of kisspeptin: implications for pregnancy
Pregnancy is dependent on the development of maternal immune tolerance to the genetically foreign fetus. During pregnancy the mother's immune reactivity and energy metabolism undergoes significant changes and the levels of certain hormones in peripheral blood are significantly increased. Hormones …
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Neuroimmune origins of behavioral disorders
… there may be a common etiology. Animal models of maternal immune activation (MIA), developed to investigate this link, suggest that maternally derived cytokines mediate fetal neurodevelopment by signaling across the placenta and upregulating inflammatory pathways within the fetal compartment. …