Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Maternal Immune Activation"”.
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Exploring the effects of maternal immune activation on cisplatin-induced toxicities.
… have suggested that early-life stressors, like maternal immune activation (MIA) may contribute to these differences in susceptibility. As MIA has been associated with alterations in stress responsivity, inflammation, and metabolism, we wanted to determine if MIA would exacerbate …
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Behavioral alterations in rat offspring following maternal immune activation and CXC chemokine receptor antagonism
… effectively treated by current antipsychotics. Maternal immune activation (MIA) during pregnancy, which can be triggered by a variety of infectious agents, has been associated with the development of schizophrenia in adult offspring. Epidemiological evidence indicates that elevated maternal …
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The impact of maternal immune activation on pig muscle development and postnatal immune function
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo terms
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Behavioral analysis of piglets exposed to a second immune challenge following maternal immune activation
The combined effects of maternal immune activation (MIA) and a second immune challenge later in life on pig behavior have not been studied. Deciphering these effects is particularly relevant in diseases that can have pronounced effects during gestation, such as porcine reproductive and respiratory …
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Role of a PTP1B Pathway in the Neuropsychiatric Expression of a Mouse Maternal Immune Activation Model
Activation of the immune system in gestating mothers has been identified as an important environmental risk factor for neuropsychiatric disorders. Maternal immune activation (MIA) animal models have been used to explore how the maternal immune system may cause expression of pathophysiology in …
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Investigations into the cellular and molecular changes in the amygdala in models of temporal lobe epilepsy and maternal immune activation
… in models of temporal lobe epilepsy (TLE) and maternal immune activation (MIA). The kainic acid (KA) model of temporal lobe epilepsy (TLE) was used to induce Ammon’s-horn sclerosis (AHS) and to investigate behavioural and cytoarchitectural changes that occur in the amygdala related to …
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Low-Input Multi-Omic Studies of Brain Neuroscience Involved in Mental Diseases
… in mice, schizophrenia, and the effect of maternal immune activation in mice offspring. The second generation of MOWChIP-seq was designed to generate histone modification profiles from as few as 100 cells per assay with a throughput as high as eight assays in each run. Then, we applied the …
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Association Between Fluoride Exposure and Immune System Biomarkers in Pregnancy
… whether fluoride exposure is associated with maternal immune system function in a Canadian pregnancy cohort. Methods: Urinary fluoride concentrations were measured in each trimester, dilution-adjusted, and averaged across pregnancy. Drinking water fluoride concentrations (WFC) were collected …
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Prenatal Environmental Stressors Impair Postnatal Microglia Function and Adult Behavior in Males
… pathogenesis, and increasingly is accompanied by immune dysfunction. Microglia are the primary immune cells in the CNS. They are important in immune host defense and are involved in normal brain development including refinement of synapses. Previous research has demonstrated that microglia are …
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Epigenomic and Transcriptomic Changes in the Onset of Disease
… we compared the epigenome and genome of murine immune cells under low-grade inflammation and acute inflammation conditions. We found that low-grade inflammation preferentially utilizes different signaling pathways than in acute inflammation, and this may lead to a non-resolving state. Finally, …
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A systems approach to determine how Toxoplasma gondii Infection causes neuropsychiatric disease
… acquired T. gondii infection, or for maternal T. gondii infection induced immune activation, to cause psychoneurological disease. The studies described herein, using LCMS (Liquid chromatography–mass spectrometry) demonstrate that adult acquired infection alters the neurochemistry and …
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Bioinformatics characterization of the molecular pathways impacted by immune challenges in the amygdala
… stressors and pathogens that elicit an immune response in the mother have the ability to influence critical processes within the fetus during development. This maternal immune activation (MIA) can have lasting effects on the fetus and has been associated with neurological and behavioral …
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The role of IL-17a in the rescue of ASD-like behavioral phenotypes following immune stimulation in a mouse model of neurodevelopmental disorders
… temperature that is typically the product of the immune response mounted in order to fight infection. Investigation into the curious connection between fever and the manifestation of ASD behavioral phenotypes is at its infancy and therefore the mechanisms underlying this phenomenon are unknown. …
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Neuroimmune origins of behavioral disorders
… there may be a common etiology. Animal models of maternal immune activation (MIA), developed to investigate this link, suggest that maternally derived cytokines mediate fetal neurodevelopment by signaling across the placenta and upregulating inflammatory pathways within the fetal compartment. …
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Understanding peripheral and brain changes in a double hit model
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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The impact of viral infection during pregnancy on maternal immunity and fetal brain development
… risk factor for NDDs. To investigate this link, maternal immune activation (MIA) is often modeled using pathogen mimics, like poly I:C. While these models have provided invaluable mechanistic insights, poly I:C induces only a partial innate immune response, whereas replicating IAV elicits a …
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ROLE OF STRESS EARLY IN LIFE AND OF INFLAMMATION IN THE RISK TO DEVELOP DEPRESSION LATER IN LIFE
… links depression to both systemic and central immune alterations. Indeed, one of the most consistent biological findings in individuals with MDD is the presence of a chronic, low-grade inflammatory state, reflected by elevated circulating levels of inflammatory biomarkers such as interleukin-6 …
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Understanding the impact of different environmental stressors across developmental stages on the hepatic metabolome
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
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Poruchy paměti a kognitivní koordinace u potkaních modelů neuropsychiatrických onemocnění
Paměť a prostorová navigace jsou pro člověka nesmírně důležité mozkové funkce a pro zvířata jsou často otázkou života a smrti. U lidí bývají poškozeny při různých neuropsychiatrických onemocněních. Pacienti trpící Alzheimerovou demencí (AD) mají narušenou pracovní i dlouhodobou paměť, navigaci v …