Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Mastermind"”.
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A new 6.111 laboratory exercise : Mastermind
Thesis (M.Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003.
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Understanding the role of the Notch intracellular domain in transcription hub formation
… complex with Suppressor of Hairless (Su(H)) and Mastermind to activate gene expression. The aim of this PhD was to further our understanding of how NICD is able to initiate target gene activation. To investigate the recruitment of NICD and its cofactors in the nucleus, it was tagged with a …
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Interpreting Notch signals: characterisation of dynamic transcription hubs by live imaging
… of Notch targets, focusing on the co-activator Mastermind, a key component of the Notch transcription complex. Specifically, its enrichment and behaviour were characterised at a regulated gene locus in Notch active cells, enabling the study of a localised hub or condensate, and how it promotes …
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Investigating transcription factor dynamics and chromatin environment during Notch response
… CSL (Su(H) in Drosophila) and the co-activator Mastermind. Binding of the activation complex promotes target gene expression. An added layer of complexity to this pathway is that Su(H) can also form a repressor complex with the co-repressor Hairless. The aim of this PhD is to understand how …
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Last night a DJ queered my life : disrupting the mythologies of a popular media practice
… jockey, or DJ, are many: beat conductor, god, mastermind, and savior, to name a few. The popular perception of what a DJ does is exaggerated by overrepresented elements of a DJ performance, most notably scratching the sound source and utilizing studio production technique. I ask, if these …
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Identifying notch-regulated genes using a specific notch signaling inhibitor
… complex by blocking the recruitment of Mastermind-like 1 (MAML1). By comparing the transcriptomic effects of DAPT and IMR-1A during osteoclast differentiation, we aimed to isolate notch-specific genes. Bone marrow-derived precursors from mice were differentiated into osteoclasts and …
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Delta Like Ligand 4 Is A Critical Regulator of Bone Marrow Cell Differentiation Into Pericytes/Vascular Smooth Muscle Cells and Is Essential For The Vasculogenesis That Supports The Growth of Ewing’S Sarcoma
… of 14 patient samples. Using dominant negative mastermind to inhibit Notch, we demonstrate that Notch signaling is essential for bone marrow cell participation in vasculogenesis. Further, inhibition of DLL4 using either shRNA or the monoclonal DLL4 neutralizing antibody YW152F led to dramatic …
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Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach
… at the interface between the ankyrin domain and Mastermind (MAML). The structural and kinetic data assisted the design of larger compounds with more extensive interactions using drug design software such as SPROUT and a docking program (GOLD). However, the optimised fragments did not show much …
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Les voies/voix radicales en Angleterre, 1789-1848
… during a trial where he was accused of being the mastermind of a modern revolution? What brought William Cobbett, an ultra-Tory, self-taught intellectual, to gradually espouse the cause of universal suffrage at a period where it was unpopular to do so? Why a whole population gathered to hear Henry …