Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 90 for “"Mast Cell"”.
-
Metabolic Regulation of Mast Cell Regranulation
<p> Mast cells (MCs) are long-lived hematopoietic cells located within tissues. These cells are densely packed with granules containing preformed bioactive components that are released within seconds to minutes upon activation in a process called degranulation. MCs have beneficial roles in pathogen …
-
Reconstitution of Munc18-Dependent Mast Cell Degranulation
<p>Mast cells are specialized secretory leukocytes that play diverse roles in the body, mediated by release of histamine and other pharmacologically active substances. Although offering essential protection in innate and adaptive immunity, mast cells are also essential to the progression of …
-
Functional characterisation of novel mast cell genes
… of data on gene expression in various tissue and cell types. Few studies have, however, taken full advantage of these data by selecting and then extensively characterising the functions of particular genes chosen from these microarray datasets. In this study, after analysing …
-
Sphingosine-1-phosphate in mast cell-mediated allergic responses
Mast cells play a critical role in both acute and chronic inflammation and mature in peripheral tissues from bone marrow-derived progenitors that circulate in the blood as immature precursors. Mast cell progenitors are likely to encounter the serum-borne bioactive sphingolipid metabolite, …
-
ADAM10: a Novel Regulator of Mast Cell Function and Activation
… first description of the role ADAM10 plays on mast cells. ADAM10 is abundantly expressed on mast cells both in vitro and in vivo. Its expression is inhibited by IL-10, a suppressive cytokine. siRNA depletion of ADAM10 on bone marrow-derived mast cells (BMMC) caused decreased IL-6 production …
-
The Role of MRGPRX2/Mrgprb2 in Regulating Mast Cell Function
Mast"cells"(MCs)"are"derived"from"bone"marrow"pluripotent"hematopoietic" stem" cells" and" are" located" in" close" proximity" to" the" external" environment." MCs" expresses"several"receptors"on"their"surface"such"as"the"high"affinity"IgE"receptor" …
-
MRGPRX2 Signaling on Mast Cell-Mediated Pseudoallergy and Neuroimmune Interaction
In addition to high affinity IgE receptor, human mast cells (MCs) express a newly identified receptor known as Mas-related G protein-coupled receptor-X2 (MRGPRX2; mouse ortholog MrgprB2). This receptor is predominantly expressed on only one subtype of MCs and it can be activated by a diverse group …
-
Unraveling the Molecular Mechanisms of Munc18 and Munc13 in Mast Cell Exocytosis
Exocytosis is a fundamental cellular process in which contents stored in vesicles are released out of cells via fusion of membranes. Exocytosis of secretory granules from immune cells such as cytotoxic T-lymphocytes, natural killer cells and mast cells play crucial physiological roles in protecting …
-
Mast Cell Influence in the Progression of Post-burn Hypertrophic Scar Pathophysiology
… severe burn injury. Investigations into cellular influences in postburn scar pathophysiology are constrained to dermal fibroblast activity in the wound and signaling among inflammatory cell populations such as neutrophils, macrophages, and T-lymphocytes. However, mast cells are known to …
-
Mast Cell Histamine Release Induced by Portuguese Man-of-War (Physalia) Venom
… the direct release of histamine from isolated mast cells. It attempts to compare this effect, histamine release, with other studies using whole tissue extracts and/or whole animals. Crude peritoneal mast cells were obtained from male Sprague-Dawley rats, washed and suspended in Locke's …
-
Determining the Roles of Q-SNAREs in Mast Cell Tumor Necrosis Factor Exocytosis
… evidence accumulates on the contributions of mast cell function to the development of allergic disorders, cardiovascular and neurological pathologies, and cancers, there is a growing recognition of the importance of mast cell-derived TNF to mast cell-mediated pathophysiology. However, our …
-
Visualizing Mast Cell Activation: Single Molecule Dynamics of Early Events in FceRI Signaling
<p>Healthy immune cell behavior requires sensitive and robust control over the processes that regulate signal transduction. In this work we employ single molecule fluorescence imaging techniques to quantify adapter protein recruitment, lateral mobility, receptor aggregation, and cytoskeletal …
-
Expression, Purification, and Characterization of the Mast Cell Proteases Chymase and Cathepsin G.
<p>Human mast cells have been associated with wound healing, allergies, inflammation, and defense against pathogens and have been detected in tissues close to blood vessels especially in the areas between the inside of the body and the external environment, such as the skin, lungs, digestive tract, …
-
Investigating the negative regulatory role of neurogranin in IgE-mediated mast cell activation
Mast cells are granulocytic immune sentinels that drive the chronic inflammatory state characteristic of allergic pathologies, through the release of a plethora of pro-inflammatory mediators following IgE-mediated activation. Calcium mobilization following mast cell activation is essential for …
-
KIT Mutations in Australian Canine Mast Cell Tumours and Correlations with Patient Prognostic Factors
Mast cell tumour (MCT) is the most common skin neoplasm in dogs. Accurately predicting MCT behaviour is essential for proper tumour management. Histological tumour grading is useful for canine prognosis and can be supplemented with the mutational evaluation of the CD117 Proto-Oncogene Receptor …
-
Interleukin-10 Suppresses Mast Cell IgE Receptor Expression And Signaling In Vitro And In Vivo
Background: Mast cells are known for their role in allergy, asthma, and systemic anaphylaxis, and have been shown to play a role in inflammatory disease. Interleukin-10 can regulate inflammatory responses both in vitro and in vivo, and may be a natural regulator of mast cell activation.Objective: …
-
Exploration of Platelet and Mast Cell Communication: A Study of Membrane Lipids, Asthma, and Inflammation
… exposure, and inflammatory diseases impact cell communication. It explores the use of different cell models, specifically platelets and mast cells, to understand how disease states can impact cellular function. Throughout the thesis, a variety of analytical techniques including …
Page 1 of 5