Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 330 for “"Mast"”.
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Impurity transport studies on MAST
… performed on the Mega Ampere Spherical Tokamak (MAST) during a two point plasma current, Ip, scan in L-mode and a confinement scan at constant Ip. For the Ip scan, a dimensionless safety factor, q, scan was attempted by using a constant toroidal magnetic field and by moderating the beam power to …
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Mast cells in gastrointestinal helminth infection
… Trichinella spiralis. It is believed that mast cell recruitment and activation may be associated with parasite expulsion from mice. In the current study, we demonstrate the role of mucosal mast cell (MMC) in gastrointestinal (GI) nematode infection and the mechanisms that may induce …
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Metabolic Regulation of Mast Cell Regranulation
<p> Mast cells (MCs) are long-lived hematopoietic cells located within tissues. These cells are densely packed with granules containing preformed bioactive components that are released within seconds to minutes upon activation in a process called degranulation. MCs have beneficial roles in pathogen …
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Reconstitution of Munc18-Dependent Mast Cell Degranulation
<p>Mast cells are specialized secretory leukocytes that play diverse roles in the body, mediated by release of histamine and other pharmacologically active substances. Although offering essential protection in innate and adaptive immunity, mast cells are also essential to the progression of …
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Functional characterisation of novel mast cell genes
… genes revealed by microarray analysis of human mast cells activated via FcåRI cross-linking, we chose two promising gene candidates for further research, A20 and Gem. Our group’s extensive gene expression database of major leukocytes showed that both A20 and Gem were up-regulated in other …
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Mast cells affect brain physiology and behavior
Mast cells are immune cells that are found in the brain. Behavioral and endocrine states increase the number and activation of brain mast cells, independent of the animal's immune status. Activation causes the release of many neuro-active mediators into the brain parenchyma. However, the function …
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Interactions of Mast Cells with the Lymphatic System: Delivery of Peripheral Signals to Lymph Nodes by Mast Cell-Derived Particles
<p>Mast cells, best known for their pathologic role in allergy, have recently been shown to have key roles in the initiation of adaptive immune responses. These cells are located throughout the body just beneath barriers separating host from environment, possess multiple pathogen recognition …
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Characterisation of Detached Plasmas on the MAST Tokamak
… describes work that was carried out on the MAST tokamak to accurately characterise the plasma conditions within divertor plasmas, and to test the validity of those measurements. To assist in this study, an interpretive code, OSM, has been upgraded with additional numerical schemes to …
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Salmonella Suppress Innate Immunity by Targeting Mast Cells
<p>Mast cells (MCs) are increasingly recognized as powerful sentinel cells responsible for modulating the early immune responses to a wide range of infectious agents. This protective role is attributable in part to their preponderance at the host-environment interface and their innate capacity to …
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Sphingosine-1-phosphate in mast cell-mediated allergic responses
Mast cells play a critical role in both acute and chronic inflammation and mature in peripheral tissues from bone marrow-derived progenitors that circulate in the blood as immature precursors. Mast cell progenitors are likely to encounter the serum-borne bioactive sphingolipid metabolite, …
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Failure of carbon fiber yacht mast in heavy weather
… considerably stronger than traditional aluminum masts. The result is increased speed, and the lighter mast also gives the boat a lower centre of gravity and so heeling and pitching is reduced. The recent spate of carbon mast failures has left concerns amongst the general yachting public about the …
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ADAM10: a Novel Regulator of Mast Cell Function and Activation
… first description of the role ADAM10 plays on mast cells. ADAM10 is abundantly expressed on mast cells both in vitro and in vivo. Its expression is inhibited by IL-10, a suppressive cytokine. siRNA depletion of ADAM10 on bone marrow-derived mast cells (BMMC) caused decreased IL-6 production …
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The Role of MRGPRX2/Mrgprb2 in Regulating Mast Cell Function
Mast"cells"(MCs)"are"derived"from"bone"marrow"pluripotent"hematopoietic" stem" cells" and" are" located" in" close" proximity" to" the" external" environment." MCs" expresses"several"receptors"on"their"surface"such"as"the"high"affinity"IgE"receptor" …
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MRGPRX2 Signaling on Mast Cell-Mediated Pseudoallergy and Neuroimmune Interaction
In addition to high affinity IgE receptor, human mast cells (MCs) express a newly identified receptor known as Mas-related G protein-coupled receptor-X2 (MRGPRX2; mouse ortholog MrgprB2). This receptor is predominantly expressed on only one subtype of MCs and it can be activated by a diverse group …
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New aspects of tissue mast cells in inflammatory airway diseases
Mast cell are found throughout the body, but are especially prominent in tissues that have direct contact with the external milieu such as the skin, gastrointestinal tract and lungs. Mast cells are commonly recognized for their detrimental role in allergic reactions and can, upon activation through …
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