Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Mass spectrometry imaging (MSI)"”.
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Detection and Imaging of Neurotransmitters in Rodent Brain Tissue Using FMP-10 and ZnO Nanoparticle Matrices with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
… laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is an analytical technique used to visualize the spatial distribution of molecules within biological samples. In our lab, we employ two complementary matrices, 2-fluoro-1-methyl pyridinium (FMP-10) and zinc oxide …
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Untargeted metabolomics and proteomics application of mass spectrometry: from biomarker identification within cells to their spatial localization on tissues
… to the implementation of liquid chromatography-mass spectrometry (LC-MS) and mass spectrometry imaging (MSI) analytical technologies, and the integration of multiple omics tools, metabolomics provides insight into the mechanisms underlying physiological and pathological conditions including …
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Imaging Glioblastoma metabolism using mass spectrometry imaging
… the microenvironment. Using isotope tracing and mass spectrometry imaging (MSI), I identified three metabolic signatures in patient GB tumours: glycolytic, oxidative and a mixed glycolytic/oxidative phenotype. These phenotypes do not correlate with microenvironmental characteristics such as …
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Characterizing neural tissues with mass spectrometry imaging via enhanced computational approaches
… heterogeneity within neural tissue, but most imaging techniques do not provide the complete information desired. To provide chemical information, most imaging techniques used to study the nervous system require preselection and labeling of the peptides of interest; however, mass spectrometry …
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Exploring chemical communication and chemical heterogeneity in biological systems with mass spectrometry imaging
… chemical communication in bacterial communities. Mass spectrometry imaging (MSI) is an untargeted and unlabeled analytical tool that enables us to look at molecular constituents in two or three dimensions. Exploring these additional spatial dimensions of heterogeneity is essential to understanding …
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Method development for mass spectrometric characterization of ultra-small nanomolecules and mass spectrometry imaging of selected biomolecules
… capabilities facilitate the applicability of mass spectrometry (MS) in diverse fields. This dissertation outlines how this cutting edge technology is used to determine the chemical composition of the ultra-small nanomolecules (NMs) to atomic precision and obtain spatial resolution of selected …
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A novel approach to processing and visualizing mass spectrometry imaging data for a new perspective in untargeted analyses
… of small molecules. Among the key techniques, mass spectrometry imaging (MSI) stands out due to its ability to identify and spatially map metabolites within a single experiment. By combining molecular analysis with morphological visualization, MSI serves as a valuable complement to classical …
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Method development for investigating chemical distributions in the nervous system using mass spectrometry imaging
… multiple methodologies are applied using mass spectrometry imaging (MSI) toward analyzing peptide distributions within the nervous system. The nervous system contains a variety of signaling molecules that are used for cell-to-cell communication, such as small molecule neurotransmitters and …
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Mass spectrometry imaging for probing molecular distributions in the nervous system
… Here, these challenges were addressed via mass spectrometry. Different mass spectrometric technologies have been applied to probe the identity and spatial distribution of analytes within spinal cord from Rattus norvegicus and neurons from Aplysia californica. Mass spectrometry imaging (MSI) …
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Molecular imaging with mass spectrometry: instrumental and methodological advances for biological applications
Mass spectrometry imaging (MSI) is an analytical technique providing a unique combination of capabilities: label-free, non-targeted, and highly multiplex detection and imaging of chemical species ranging in mass from single protons to large proteins exceeding 100 kDa, identifiable by mass and …
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Mass Spectrometry Imaging: Looking Fruits at Molecular Level
Mass spectrometry imaging (MSI) is a MS-based technique. It provides a way of ascertaining both spatial distribution and relative abundance of a large variety of analytes from various biological sample surfaces. MSI is able to generate distribution maps of multiple analytes simultaneously without …
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Secondary ion mass spectrometry imaging of surface-bound microbial communities
… and application of an existing chemical imaging technique, secondary ion mass spectrometry (SIMS) imaging, to study the chemistry underlying surface-bound microbial communities. The first chapter provides a general overview of the dissertation. The second chapter provides an introduction …