Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 46 for “"Mass spectrometers"”.
-
Monolithically 3-D Printed, Quadrupole Mass Filter for High-Precision, Compact, CubeSat Mass Spectrometry
Mass spectrometry is the gold standard for quantitative chemical analysis. However, mainstream mass spectrometers are large, heavy, and power hungry, restricting their ability to be deployed into in-situ, portable, and hand-held scenarios, e.g., drones and CubeSats (measurements in the atmosphere …
-
Chip-scale quadrupole mass filters for a Micro-Gas Analyzer
Mass spectrometers are powerful analytical instruments that serve as the gold standard for chemical analysis. This tool has numerous applications ranging from national security, industrial processing, environmental monitoring, space exploration, and healthcare to name a few. These systems are …
-
MINIATURE MASS SPECTROMETER SYSTEM WITH A SAMPLING PROBE
… thesis focuses on the development of miniature mass spectrometry systems and the sampling probes. Mass spectrometers are usually installed and used in the analytical laboratory. It requires complex sample preparation before the analysis. Use of miniature mass spectrometer enables the chemical …
-
Studies on the detection of nucleotides and oligonucleotides by mass spectrometry
… and modified nucleotides such as DNA adducts by mass spectrometry. DNA adducts are important because they are formed during chemical carcinogenesis as well as during anti-cancer chemotherapy. However, DNA adducts are not routinely monitored due to difficulties associated with their detection. …
-
Design and implementation of a custom imaging mass spectrometer.
Mass spectrometry (MS) has been demonstrated as one of the most robust and capable analytical tools for chemical analysis. As such, MS has found application across practically every field of science today. One notable area where MS is used today is in the analysis of biological samples, such as …
-
Surface Acoustic Wave Nebulization as a Mass Spectrometry Ionization Source, Characterization and Application
… describes a novel method to generate ions for mass spectrometers that simplifies the operation and decreases the internal energy distribution of ions. The surface acoustic wave nebulization (SAWN) is a nebulization method generating both positive and negative ions from liquid phase. We have …
-
Methods for the estimation and application of biological networks
… data from technologies like microarrays and mass spectrometers has transformed both biology and statistical theory; however, the tremendous potential of these datasets to explore the interactive behavior of genes or proteins has been largely unexplored. This dissertation describes two …
-
MASS SPECTROMETRIC STUDIES ON PETROLEUM ASPHALTENES AND ORGANOSULFUR COMPOUNDS, ON FUNCTIONAL-GROUP SELECTIVE ION-MOLECULE REACTIONS AND ON GAS-PHASE REACTIVITY OF META-BENZYNES TOWARD AMINO ACIDS
Mass spectrometry has found a wide variety of applications in many fields of study, such as fundamental chemistry, biological science, food and fuels, advanced materials, etc. Due to its high sensitivity, selectivity and speed, mass spectrometry provides an invaluable tool for direct mixture …
-
Development of Additively Manufactured Quadrupole Mass Filters for Low-Cost and High-Performance Applications
… a growing need for more compact and affordable mass spectrometers, many efforts have been made to miniaturize quadrupole mass filters (QMFs). Unfortunately, these efforts have yielded devices with inadequate performance for practical applications in analytical chemistry. This study reports the …
-
Signal variation in single particle aerosol mass spectrometry
… One approach to such detection, bioaerosol mass spectrometry (BAMS), is currently under development at Lawrence Livermore National Laboratory. BAMS is a type of single particle aerosol mass spectrometry that rapidly records dual-polarity mass spectra of aerosolized micro-particles. However, …
-
The Potential of Bulk and Amino-Acid Specific Isotope Ratio Mass Spectrometry of Human Hair in Forensic and Clinical Applications
Isotope Ratio Mass Spectrometry (IRMS) is a specialized technique used to measure the isotopic ratios at natural abundance of the non-radioactive isotopes, and has proved to be a valuable tool in many applications. This research explores the use of IRMS of human hair for clinical and forensic …
-
Real-time Feature Detection in Mass Spectrometer Data
… pre-processing of the complex files created by mass spectrometers during proteomics experiments is required before it is possible to gain any insight from them. A typical mass spectrometer run may produce forty thousand scans of data each containing around two thousand data points. If this data …
-
Design and Qualification of a Coded Aperture Cycloidal Mass Spectrometer to Detect Perfluorocarbon Tracer Molecules for Environmental Applications
… required. A cycloidal coded aperture miniature mass spectrometers (C-CAMMS) could be such a method due to its integration of three core technologies that help to overcome the throughput versus resolution tradeoff that has historically hampered the miniaturization of mass spectrometers. The …
-
Development Of Matrix Assisted Ionization Methods For Characterization Of Soluble And Insoluble Proteins From Native Environments By Mass Spectrometry
… formation of multiply charged ion extends the mass range of high performance mass spectrometers with advanced features for structural characterization such as ultra-high mass resolution and mass accuracy, and electron transfer dissociation. The surface method approach enables the detection, …
-
The Application of Innovative High-Throughput Techniques to Serum Biomarker Discovery
<p>Time-of-flight mass spectrometry continues to evolve as a promising technique for serum protein expression profiling and biomarker discovery. As seen in our initial SELDI-TOF MS and MALDI-TOF MS profiling study of serum for the assessment of breast cancer risk, many profiling strategies …
-
GLYCOPEPTIDE ANALYSIS OF HIV-1 ENVELOPE PROTEIN USING HPLC/ESI-FTICR MS AND MALDI-TOF MS WITH ASIALOFETUIN ENRICHMENT AND SEPARATION TECHNIQUES
… modification that provides diverse glycoforms. Mass spectrometry has become a standard technique for characterizing the site occupancy and glycoforms that a protein exhibits. Methodologies in characterization of glycopeptides often include a proteolytic digest followed by purification of the …
-
Single-particle instrument simulator: Bridging experiments and models
… models such as PartMC track the mass of each species per particle, whereas single-particle mass spectrometers report ion signals as a function of mass-to-charge ratios. Since ion signals depend not only non-linearly on species mass but also on species-specific ionization …
-
A sub-ppb measurement of the mass of cesium for a new determination of the fine-structure constant
… thesis describes recent single-ion Penning trap mass spectrometry measurements of the mass of atomic Cesium with a relative uncertainty of 2 x 10-10. This measurement reduces the uncertainty on the mass of Cesium by a factor of 100, and removes this uncertainty as a limitation on the accuracy of …
-
Computational Analysis of LC-MS/MS Data for Metabolite Identification
… development on high-resolution, high-accuracy mass spectrometers enables the simultaneous study of hundreds or even thousands of metabolites in one experiment. Liquid chromatography-mass spectrometry (LC-MS) is a commonly used instrument for metabolomic studies due to its high sensitivity and …
-
Development Of Inlet And Vacuum Ionization Methods For Characterization Of Biological Materials By Mass Spectrometry
… characterization from surfaces and extending the mass range of high performance mass spectrometers. Operating from AP provides the potential for vacuum ionization to be applied in high throughput analysis. The continuous ion formation also benefits matrix assisted ionization vacuum (MAIV) for drug …
Page 1 of 3