Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Mass Spectrometry Imaging"”.
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Imaging Glioblastoma metabolism using mass spectrometry imaging
… the microenvironment. Using isotope tracing and mass spectrometry imaging (MSI), I identified three metabolic signatures in patient GB tumours: glycolytic, oxidative and a mixed glycolytic/oxidative phenotype. These phenotypes do not correlate with microenvironmental characteristics such as …
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Mass Spectrometry Imaging: Looking Fruits at Molecular Level
Mass spectrometry imaging (MSI) is a MS-based technique. It provides a way of ascertaining both spatial distribution and relative abundance of a large variety of analytes from various biological sample surfaces. MSI is able to generate distribution maps of multiple analytes simultaneously without …
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Secondary ion mass spectrometry imaging of surface-bound microbial communities
… and application of an existing chemical imaging technique, secondary ion mass spectrometry (SIMS) imaging, to study the chemistry underlying surface-bound microbial communities. The first chapter provides a general overview of the dissertation. The second chapter provides an introduction …
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A framework for the statistical analysis of mass spectrometry imaging experiments
<p>Mass spectrometry (MS) imaging is a powerful investigation technique for a wide range of biological applications such as molecular histology of tissue, whole body sections, and bacterial films , and biomedical applications such as cancer diagnosis. MS imaging visualizes the spatial distribution …
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MALDI Mass Spectrometry Imaging for the Discovery of Prostate Carcinoma Biomarkers
… of proteins in tissue sections using MALDI imaging mass spectrometry (MALDI-IMS) has the power to link molecular detail to morphological and pathological changes, enhancing the ability to identify candidates for new specific biomarkers. However, critical questions remain regarding the …
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Mass spectrometry imaging for probing molecular distributions in the nervous system
… Here, these challenges were addressed via mass spectrometry. Different mass spectrometric technologies have been applied to probe the identity and spatial distribution of analytes within spinal cord from Rattus norvegicus and neurons from Aplysia californica. Mass spectrometry imaging (MSI) …
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Characterizing neural tissues with mass spectrometry imaging via enhanced computational approaches
… heterogeneity within neural tissue, but most imaging techniques do not provide the complete information desired. To provide chemical information, most imaging techniques used to study the nervous system require preselection and labeling of the peptides of interest; however, mass spectrometry …
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Exploring chemical communication and chemical heterogeneity in biological systems with mass spectrometry imaging
… chemical communication in bacterial communities. Mass spectrometry imaging (MSI) is an untargeted and unlabeled analytical tool that enables us to look at molecular constituents in two or three dimensions. Exploring these additional spatial dimensions of heterogeneity is essential to understanding …
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Investigation of Phosphatidylinositols and Phosphoinositides Using Matrix- Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a powerful analytical technique that captures the spatial distribution of biomolecules directly from tissue surfaces. Widely used in lipidomics, MALDI-MSI provides label-free, high-resolution imaging of lipid …
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Method development for investigating chemical distributions in the nervous system using mass spectrometry imaging
… multiple methodologies are applied using mass spectrometry imaging (MSI) toward analyzing peptide distributions within the nervous system. The nervous system contains a variety of signaling molecules that are used for cell-to-cell communication, such as small molecule neurotransmitters and …
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Metabolomic insights into Pseudomonas aeruginosa behavior, secretome, and biofilm development using mass spectrometry imaging
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
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Method development for mass spectrometric characterization of ultra-small nanomolecules and mass spectrometry imaging of selected biomolecules
… capabilities facilitate the applicability of mass spectrometry (MS) in diverse fields. This dissertation outlines how this cutting edge technology is used to determine the chemical composition of the ultra-small nanomolecules (NMs) to atomic precision and obtain spatial resolution of selected …
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A novel approach to processing and visualizing mass spectrometry imaging data for a new perspective in untargeted analyses
… of small molecules. Among the key techniques, mass spectrometry imaging (MSI) stands out due to its ability to identify and spatially map metabolites within a single experiment. By combining molecular analysis with morphological visualization, MSI serves as a valuable complement to classical …
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Machine Learning for Physics Applications: Quantum Algorithm Design, Chaotic Dynamics, and Mass Spectrometry
… paradigm to two further domains: mass spectrometry imaging and non-linear chaotic dynamics. In the second chapter, supervised and interpretable machine learning models are applied to mass spectrometry imaging data to identify chemical biomarkers and quantify spatial and spectral …
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The use of MALDI-MS for imaging drug disposition in respiratory disease models.
Matrix-assisted laser desorption/ionisation-mass spectrometry imaging (MALDI-MSI) has been extensively applied to monitoring the distribution of pharmaceutical compounds in tissues. The main aim of the work reported in this thesis is to monitor the distribution of respiratory compounds in the lungs …
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Detection and Imaging of Neurotransmitters in Rodent Brain Tissue Using FMP-10 and ZnO Nanoparticle Matrices with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
… laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is an analytical technique used to visualize the spatial distribution of molecules within biological samples. In our lab, we employ two complementary matrices, 2-fluoro-1-methyl pyridinium (FMP-10) and zinc oxide …
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Untargeted metabolomics and proteomics application of mass spectrometry: from biomarker identification within cells to their spatial localization on tissues
… to the implementation of liquid chromatography-mass spectrometry (LC-MS) and mass spectrometry imaging (MSI) analytical technologies, and the integration of multiple omics tools, metabolomics provides insight into the mechanisms underlying physiological and pathological conditions including …
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Analysis of Cancer Margins in Mass Spectrometry Images
… resection. One method to collect this data is mass spectrometry imaging, an analytical technique that can detect the patterns of metabolites within a sample and retain the spatial information. The patterns of metabolites can provide further insight into the functioning of cells. Our data …
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