Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 190 for “"Mass Spectrometry (MS)"”.
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Mass Spectrometric Studies on Lignin Sequencing and Fast Pyrolysis, Functional-Group Selective Ion-Molecule Reactions and Reactivity of Bi- and Triradicals
… to the high sensitivity, selectivity and speed, mass spectrometry (MS) has proved to be an invaluable tool for mixture analysis and structural elucidation of mixture components. Tandem mass spectrometry (MS/MS) utilizing collision-activated dissociation (CAD) has become the technique of choice …
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Synthesis, Characterization, And Rna Reactivity Of Amino-Acid-Linked Cisplatin Analogues
… magnetic resonance (NMR) spectroscopy, and mass spectrometry (MS). Tandem mass spectrometry (MS/MS) combined with computational chemistry was also utilized to assess the effects of Pt(II) on the glycosidic-bond strength of the purine nucleoside, and to obtain an atomic-level understanding of …
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Supercritical Fluid Extraction and Chromatography of Various Lipids from Soybean Lecithin
… refractive index, flame ionization detector, and mass spectrometry (MS) detection have long been used in the study of phospholipids. These methods were time-consuming and lacked quantitative accuracy. In this work, phosphatidylcholine, phosphatidyl-ethanolamine, phosphatidylinositol and …
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Skysčių chromatografija–tandeminė masių spektrometrija antibiotikų nustatymui maisto produktuose /
… (UPLC) techniques coupled with tandem mass spectrometry (MS/MS) were developed for the determination of common antibiotics (chloramphenicol, sulfonamides and nitroimidazoles together with their metabolites) in food products. HPLC/UPLC and MS/MS conditions were optimized for the …
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NEW METHODS TO QUANTIFY METHIONINE OXIDATION AND PROTEIN GLYCOSYLATION AND A DE NOVO GLYCOPEPTIDE DECOY GENERATOR
Protein post-translational modifications (PTMs) produce complex, heterogeneous species that can best be identified and analyzed using mass spectrometry (MS). The ever-growing number of protein bioetherapeutics need effective MS tools to characterize PTMs and ensure drug safety and efficacy. …
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Investigation of ion transfer efficiency through multi-channel capillaries for a Desorption Electrospray Ionization (DESI) interface
… Electrospray Ionization (DESI) coupled with mass spectrometry (MS) is an efficient imaging technique for obtaining the spatial distribution of molecular species from a surface. In this study, we experimented with different capillary geometries to maximize the signal intensity of analyte peaks …
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On-chip multi-dimensional biomolecule separation using multi-layer microfabricated valves
… (PAGE), CE, reverse-phase chromatography, and mass spectrometry (MS).
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Statistical Inference and Community Detection in Proximity and Spatial Proteomics: Resolving the Organization of the Neuronal Proteome
<p>Technological advances in protein mass spectrometry (MS), aka proteomics, haveenabled high-throughput quantification of spatially-resolved, subcellular-specific proteomes. Biological insight in these experiments depends upon sound statistical analysis. Despite the myriad of existing proprietary …
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From Solution Into the Gas Phase: Studying Protein Hydrogen Exchange and Electrospray Ionization Using Molecular Dynamics Simulation
… to investigate fundamental aspects of structural mass spectrometry (MS). We first examine microscopic phenomena underlying Hydrogen/Deuterium exchange (HDX). HDX interrogates structural dynamics of proteins by measuring the rate of Deuterium uptake into backbone amides. We perform microsecond MD …
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Synthesis And Application Of Atp Analogs For Phosphorylation-Dependent Kinase-Substrate Crosslinking
… when coupled with analytical techniques like Mass Spectrometry (MS). These tools will help us in validating our</p> <p>understanding of protein-protein interactions, their role in signaling pathways and functioning of the cell.</p>
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Advance metabolite identification from tandem mass spectra using deep generative models
Tandem mass spectrometry (MS/MS) is a modern technique for measuring metabolites. MS/MS spectra represent molecules by the fragment patterns of compounds that contain structural features of the precursor molecules. The database-searching strategy is the most popular for metabolite identification …
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Biochemical characterizations of extracellular vesicles shed by vegetative and sporulating Bacillus subtilis
… Bacillus subtilis cells and characterized using mass spectrometry (MS)-based proteomics, microscopy, and fluorescence spectrophotometry. The microscopic approach demonstrated that both vegetative and sporulating cells produce EVs. In the proteomic analysis, 156 proteins were identified with …
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New Derivatization Strategies for Installation of Fixed, Permanent Charges onto Analytes of Biological and Environmental Concern
Mass spectrometry (MS) is a highly sensitive analytical technique that can be used to identify thousands of analytes from a single biological matrix. Chemical derivatization (CD) reagents can enhance analyte detection and quantification by adding a specific functional group that enhances ionization …
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Ambient Ionization Mass Spectrometry Analysis Pertaining To Biofuel Process Development
<p>Mass spectrometry (MS) has undergone a revolution with the introduction of a new group of desorption/ionization (DI) techniques known collectively as Ambient Ionization mass spectrometry. Ambient ionization mass spectrometry allows for direct analysis of analytes and typically requires little or …
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Identification and enantioselective determination of protein amino acids in fertilizers by hydrophilic interaction and chiral chromatography coupled to tandem mass spectrometry /
… liquid chromatography coupled (HPLC) to tandem mass spectrometry (MS/MS) was involved for amino acids identification and enantioselective quantification studies. Direct amino acids identification assay in HPF samples was developed in hydrophilic interaction chromatography (HILIC) mode with …
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The detection and characterisation of novel alkyl spin-adducts of PBN and its derivatives using capillary gas chromatography coupled to electron-ionisation mass spectrometry
… techniques of gas chromatography (GC) and mass spectrometry (MS). The significant findings of this work involve trapping various radicals such as propyl radicals, 2-methyl propyl radicals, butanal radicals (oxoallylic radicals), 2-methyl butanal radicals and methyl radicals in various …
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Development of ambient mass spectrometry methods for investigating iron-catalyzed oxidation reactions
… give indirect insight into a reaction mechanism, mass spectrometry (MS) is unparalleled in the level of chemical specificity. Ambient MS methods can capture fleeting intermediates of catalytic cycles with reaction times of a few milliseconds or less, and the novel methodology described in this …
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Mass Spectrometric Studies on the Primary Products of Fast Pyrolysis of Carbohydrates and the Molecular Structures of Asphaltenes, and the Development of a Rastering Probe for Laser-Induced Acoustic Desorption into an Atmospheric Pressure Chemical Ionization Source
<p>Mass spectrometry (MS) has proven invaluable in the field of mixture analysis and structural elucidation. Tandem mass spectrometry (MS/MS) utilizing collision-activated dissociation (CAD) has become the technique of choice for structural elucidation of unknown analytes in mixtures. When coupled …
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Investigations of Serotonin Metabolism in Mammalian and Other Deuterostome Model Systems
… acetic acid (5-HIAA) in these organisms. A novel 5-HT metabolite in the rat (Rattus norvegicus ), 5-hydroxyindole thiazolidine carboxylic acid (5-HITCA), was characterized via mass spectrometry (MS) and further investigated using CE. Levels of 5-HT and some of its key metabolites were …
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Comprehensive proteomic profiling of clinically relevant strains of Mycobacterium tuberculosis
… discrepancies in phenotypic presentation in terms of virulence, elicited immune response and transmissibility. This study aims to use Mass Spectrometry (MS) tools to quantitatively and qualitatively investigate the total proteome expressed by various epidemiologically significant strains within …
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