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Showing 1 to 11 of 11 for “"Mash1"”.
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Funktionsanalyse der Entwicklungskontrollgene Irx2 und Mash1 in der Maus.
… konnte für die orthologen Gene - Irx2 und Mash1 - in der Maus nicht bestätigt werden. Die vorgenommene Analyse der Mash1-Mutante hingegen zeigt die essentielle Funktion des Gens in der Differenzierung der Calcitonin-produzierenden C-Zellen in der Schilddrüse der Maus. Die funktionellen …
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Mash1 Defines Lineage Restricted Neuronal and Oligodendrocytic Precursor Cells in Spinal Cord Development
… to adult neuron types. The transcription factor Mash1 is transiently expressed in a subset of neural progenitors and possesses a pro-neural function. The transient nature of its expression limits the ability to trace Mash1+ progenitors. To study the developing neural tube from progenitor to adult …
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Neurogenesis and Gliogenesis from Ascl1 (Mash1) Expressing Progenitors in the Central Nervous System
… nervous system structures. Ascl1 (previously Mash1) is a bHLH transcription factor essential for neuronal differentiation and neural sub-type specification. Ascl1 is present in proliferating progenitor cells but these cells are actively differentiating as evidenced by their rapid migration out …
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Funktionen und Interaktionen von Homöodomänenproteinen während der Entwicklung des Rückenmarks
… des bHLH (basic Helix-Loop-Helix) Proteins Mash1, ein essentieller Faktor für ein erregendes dI3 und dI5 Zellschicksal, aufrecht, indem sie den bHLH Transkriptionsfaktor Ngn1 hemmen. Die Expression dieses Proteins grenzt im Wildtyp sowohl dorsal als auch ventral an die Gsh1/2+ Domäne an. …
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TrkB and gene expression
… demonstrated, both in vivo and in vitro, that Mash1 and NeuroD are the members of bHLH family that bind C/EBP transcription factors at different domains. That interaction is BDNF independent, and the complex is constitutively present on the c-fos promoter. The BDNF regulation of gene expression …
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Identification, regulation and lineage tracing of embryonic olfactory progenitors
… where GFP is found in a subpopulation of GFP+ Mash1+ neuronal progenitors, despite the fact that endogenous nestin expression is found in RGLPs throughout the OE. In vitro, embryonic OE progenitors produce three biologically distinct colony subtypes, that when generated from Nestin-cre/ZEG …
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The Role of Transcription Factors in Regulating Adult Neurogenesis after Excitotoxic Brain Injury
… Expression of the transcription factors Mash1, Dlx2, Pax6 and Olig2 in transitamplifying- precursor cells (TAPs) and neuroblasts was examined following quinolinic acid (QA) lesioning of the adult rat striatum. It was demonstrated that TAPs responded to lesioning in a heterogeneous manner, …
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Funktionsanalyse des Irx1-Gens
… von Irx1 ergab, daß keine Aktivierung des Mash1-Promotors vorliegt. Die Regulation Gli-Irx-Mash ist in der Maus nur teilweise evolutiv erhalten geblieben, so sind die Interaktionspartner der regulativen Kaskade identisch, aber nicht die funktionelle Ausprägung. Die Funktion von Irx1 wurde …
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Untersuchungen der Funktion des Kleinhirns mit Hilfe von Mausmutanten
… zur Identifikation von Transkriptionsfaktoren (MASH1, PTF1a, NGN2), die eher für die Determinierung eines GABA-ergen Zellschicksals und während der Migration von IN eine Rolle spielen, als für spätere, spezifische Differenzierungsstadien. Der bHLH-TF NDRF wird in postmitotischen Körner-, Stern- …
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Uncovering the role of notch signaling in development of hypothalamic nuclei in vivo and using in vitro microenvironments
… a significant increase in the proneural gene Mash1, suggesting that some of the machinery required for progenitor differentiation was present in cultured progenitors. In vitro results recapitulated some in vivo findings, as we noted significant increases in mKi67 and Olig2 transcript. However, …
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Role of Sonic Hedgehog in Development of the Central Nervous System
Sonic hedgehog (Shh) functions as a morphogen to induce early dorso-ventral patterning of the central nervous system (CNS) and specifies cell fates of spinal motor neurons. Shh has also been known to promote cell cycle progression of embryonic stem cells as well as adult neural stem/progenitor …